Results 21 to 30 of about 11,202 (179)

Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?

Frontiers in Endocrinology, 2021
Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic
Sanna Laurila, Sanna Laurila, Sanna Laurila, Eleni Rebelos, Miikka-Juhani Honka, Pirjo Nuutila, Pirjo Nuutila   +6 more
doaj   +1 more source

MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors [PDF]

Journal of Molecular Endocrinology, 2014
In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs.
Chow, BKC, JIN, J, Tam, JKV, Lee, LTO
openaire   +4 more sources

Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling

Gut Microbes, 2023
Intestinal microbes impact the health of the intestine and organs distal to the gut. Limosilactobacillus reuteri is a human intestinal microbe that promotes normal gut transit, the anti-inflammatory immune system, wound healing, normal social behavior in
Heather A. Danhof, Jihwan Lee, Aanchal Thapa, Robert A. Britton, Sara C. Di Rienzi   +4 more
doaj   +1 more source

Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice

Frontiers in Cellular and Infection Microbiology, 2023
The gut microbiota plays a vital role in maintaining gastrointestinal homeostasis, however, whether it is influenced by gut hormones remains unknown. Secretin is a well-known gastrointestinal hormone produced by enteroendocrine S cells.
Fengwei Zhang, Zhengyi Tao, Congjia Chen, Billy Kwok Chong Chow   +3 more
doaj   +1 more source

Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.

PLoS ONE, 2011
Background & aimsSecretin induces bicarbonate-rich hydrocholeresis in healthy individuals, but not in untreated patients with primary biliary cirrhosis (PBC). Ursodeoxycholic acid (UDCA)--the first choice treatment for PBC--restores the secretin response.
Miriam Úriz, Elena Sáez, Jesús Prieto, Juan F Medina, Jesús M Banales   +4 more
doaj   +1 more source

Efficacy and Safety of Pancreatic Juice Cytology with Synthetic Secretin in Diagnosing Malignant Intraductal Papillary Mucinous Neoplasms of the Pancreas

Diagnostics, 2022
The risk of malignant transformation of intraductal papillary mucinous neoplasm (IPMN) is presently assessed using imaging, which remains unsatisfactory.
Yohei Takeda, Kazuya Matsumoto, Takumi Onoyama, Taro Yamashita, Hiroki Koda, Wataru Hamamoto, Yuri Sakamoto, Takuya Shimosaka, Shiho Kawahara, Yasushi Horie, Hajime Isomoto   +10 more
doaj   +1 more source

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice

Frontiers in Cellular Neuroscience, 2019
In mammals, reproduction is regulated by a wide range of metabolic hormones that maintain the proper energy balance. In addition to regulating feeding and energy expenditure, these metabolic messengers also modulate the functional performance of the ...
Veronika Csillag, Veronika Csillag, Csaba Vastagh, Zsolt Liposits, Zsolt Liposits, Imre Farkas   +5 more
doaj   +1 more source

Scaffolding Protein GspB/OutB Facilitates Assembly of the Dickeya dadantii Type 2 Secretion System by Anchoring the Outer Membrane Secretin Pore to the Inner Membrane and to the Peptidoglycan Cell Wall

mBio, 2022
The phytopathogenic proteobacterium Dickeya dadantii secretes an array of plant cell wall-degrading enzymes and other virulence factors via the type 2 secretion system (T2SS).
Shiheng Zhang, Shuang Gu, Piers Rycroft, Florence Ruaudel, Frederic Delolme, Xavier Robert, Lionel Ballut, Richard W. Pickersgill, Vladimir E. Shevchik   +8 more
doaj   +1 more source

Secretin Modulates the Postnatal Development of Mouse Cerebellar Cortex Via PKA- and ERK-dependent Pathways

Frontiers in Cellular Neuroscience, 2017
Postnatal development of the cerebellum is critical for its intact function such as motor coordination and has been implicated in the pathogenesis of psychiatric disorders.
Lei Wang, Li Zhang, Billy K. C. Chow
doaj   +1 more source

Structural characterization of outer membrane components of the type IV pili system in pathogenic Neisseria. [PDF]

PLoS ONE, 2011
Structures of the type IV pili secretin complexes from Neisseria gonorrhoeae and Neisseria meningitidis, embedded in outer membranes were investigated by transmission electron microscopy. Single particle averaging revealed additional domains not observed
Samta Jain, Katarzyna B Mościcka, Martine P Bos, Emilia Pachulec, Marc C A Stuart, Wilko Keegstra, Egbert J Boekema, Chris van der Does   +7 more
doaj   +1 more source