Utility of Fecal Elastase‐1 in Estimating Exocrine Pancreatic Function in Cystic Fibrosis: A Scoping Review [PDF]
Pediatric Pulmonology, Volume 61, Issue 5, May 2026.ABSTRACT Background In people with cystic fibrosis (pwCF), identification of exocrine pancreatic insufficiency (EPI) is essential to prevent steatorrhea and, if not managed actively, can lead to catastrophic consequences. Fecal elastase‐1 (FE‐1) is a widely used test to screen for EPI in cystic fibrosis (CF).
Senthilkumar Sankararaman +3 more
wiley +2 more sources
Secretin targets interstitial cells of Cajal to regulate intestinal contractions. [PDF]
EMBO RepSecretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by ...
Bartlett AM +3 more
europepmc +2 more sources
Structural insights into the secretin complex of a type IVb pilus system. [PDF]
Nat CommunThe bundle-forming pilus (BFP) system in enteropathogenic Escherichia coli (EPEC) produces type IVb pili that enable bacterial auto-aggregation, facilitating bacterial adhesion, colonization, and virulence.
Pei C +8 more
europepmc +2 more sources
AEG‐AESPANC‐OPGE‐SIED‐SPG Ibero‐Latin American Guidelines on Acute Pancreatitis (iLATAM‐AP) [PDF]
United European Gastroenterology Journal, Volume 14, Issue 5, June 2026.ABSTRACT Introduction Acute pancreatitis (AP) is a major cause of gastrointestinal hospitalizations worldwide. Although typically self‐limiting, up to one‐third of cases develop complications associated with increased morbidity and mortality. Despite recent advances that have improved outcomes, clinical heterogeneity necessitates updated, evidence ...
Karina Cárdenas‐Jaén +44 more
wiley +2 more sources
PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa. [PDF]
Nat CommunType IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a pivotal role in adhesion, surface motility, biofilm formation, and infection in humans.
Guo S +5 more
europepmc +2 more sources
Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. [PDF]
PLoS ONE, 2011 At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear.
Janice K V Tam +7 more
doaj +1 more source
A proform of secretin with high secretin‐like bioactivity [PDF]
FEBS Letters, 1985 A variant form of the heptacosapeptide amide secretin, with C‐terminal‐Val‐Gly‐Lys‐Arg instead of valine amide, has been isolated from porcine upper intestinal tissue. Unexpectedly, this triacontapeptide exhibited a substantially higher bioactivity than the heptacosapeptide amide.
Gafvelin, Guro +2 more
openaire +2 more sources
Molecular Metabolism, 2023 Objective: Obesity is a major global health problem which can be targeted with new mechanistic diverse pharmacological interventions. Here we evaluate a new long-acting secretin receptor agonist as a potential treatment for obesity.
Mona Loeffler +6 more
doaj +1 more source
The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder
Frontiers in Cellular Neuroscience, 2020 Gut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions.
Xin-Rui Qi, Li Zhang
doaj +1 more source
Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. [PDF]
PLoS ONE, 2016 The pleiotropic role of human secretin (hSCT) validates its potential use as a therapeutic agent. Nevertheless, the structure of secretin in complex with its receptor is necessary to develop a suitable therapeutic agent. Therefore, in an effort to design
Kailash Singh +8 more
doaj +1 more source