Results 11 to 20 of about 15,697 (209)

SCTR-Expressing Astrocyte-Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac-Foxc2 Epigenetic Axis in an AMPK-Dependent Manner. [PDF]

Adv Sci (Weinh)
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Meng F, Liu J, Dai J, Wu M, Wang W, Zhang M, Jiang S, Cao Y, Xu L, Du L, Wang D, Zhao D, Qin G, Wang D, Li W, Li C.   +15 more
europepmc   +2 more sources

Impaired Renal Base Excretion in Secretin Receptor Knock-Out Mice During Prolonged Base-Loading. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Secretin was recently found to play a pivotal role in the renal adaptation to acute base excess. Here, secretin increases pendrin‐dependent HCO3− secretion from the beta‐intercalated cells in the cortical collecting ducts. Whether secretin and its receptor play a role during prolonged base‐loading remains unknown.
Jensen T, Andersen JF, Trans LW, Modvig IM, Vitzthum H, Holst JJ, Hartman B, Svendsen SL, Sørensen MV, Leipziger J, Berg P.   +10 more
europepmc   +2 more sources

Disordered pancreatic and gastrointestinal hormone responses to nutrient stimulation in Zambian children with severe acute malnutrition. [PDF]

Exp Physiol
Abstract Nutrient sensing enables the body to detect and respond to nutrient availability through hormonal regulation. In this study, we examined nutrient‐stimulated hormonal responses in children with severe acute malnutrition (SAM) compared with hospitalized (HC) and community (CC) child comparators.
Besa E, Phiri R, Tembo A, Nayame G, Ngongola A, Rehfeld J, Hartmann B, Frost G, Heimburger DC, Kelly P.   +9 more
europepmc   +2 more sources

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Cifuentes P, Garriga A, Fontaine F, Zamora I.   +3 more
europepmc   +2 more sources

The Therapeutic Potential of Purmorphamine Across Disease Models. [PDF]

J Cell Mol Med
ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Dhar A, Sharar AD, Papisetty S, Bydon M, Moinuddin FM.   +4 more
europepmc   +2 more sources

Secretin interactions in the type II secretion system [PDF]

, 2012
PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
core   +4 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U-87 MG cells. [PDF]

FEBS Open Bio
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Gupta P, Furness SG, Gharbi T, De Paoli-Iseppi R, Joshi SS, Clark M, Hare DL, Wookey P.   +7 more
europepmc   +2 more sources

MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors [PDF]

Journal of Molecular Endocrinology, 2014
In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs.
Chow, BKC, JIN, J, Tam, JKV, Lee, LTO
openaire   +4 more sources

Intrinsic Disorder as a New Frontier in Antimicrobial Resistance and Bacterial Fitness [PDF]

Microbiologyopen
The works examines the link between intrinsic disorder in bacterial protein structure, and bacterial function, and antimicrobial resistance. It highlights how flexible, disordered proteins support secretion, stress responses, desiccation protection, and virulence, while also suggesting that these adaptable regions may provide novel targets for ...
O' Callaghan J, Ryan M, Hudson S, Thompson D.   +3 more
europepmc   +2 more sources

Efficacy and Safety of Pancreatic Juice Cytology with Synthetic Secretin in Diagnosing Malignant Intraductal Papillary Mucinous Neoplasms of the Pancreas

Diagnostics, 2022
The risk of malignant transformation of intraductal papillary mucinous neoplasm (IPMN) is presently assessed using imaging, which remains unsatisfactory.
Yohei Takeda, Kazuya Matsumoto, Takumi Onoyama, Taro Yamashita, Hiroki Koda, Wataru Hamamoto, Yuri Sakamoto, Takuya Shimosaka, Shiho Kawahara, Yasushi Horie, Hajime Isomoto   +10 more
doaj   +1 more source