Results 151 to 160 of about 54,955 (220)

Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]

open access: yes, 2009
The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Greene, W.K.   +4 more
core   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

open access: yesInternational Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta   +10 more
wiley   +1 more source

转录因子GATA家族在人血管内皮细胞中的表达

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2008
【目的】 了解转录因子GATA家族在人血管内皮细胞中表达的情况65377;【方法】 体外培养人的脐静脉内皮细胞(HUVECs)65380;主动脉内皮细胞(HAECs)65380;肺动脉内皮细胞(HPAECs)及肠系膜动脉内皮细胞(HMAECs) 4种血管内皮细胞,取1×106个上述细胞采用RT*9鄄PCR法检测转录因子GATA家族mRNA在人的上述四种血管内皮细胞中的表达情况并对结果进行定性分析65377;【结果】 GATA*9鄄2 mRNA 及GATA*9鄄3 mRNA在上述4种血管内皮细胞中均表达 ...
doaj  

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

Increased T-bet/GATA-3 and ROR-γt /Foxp3 Ratios in Cerebrospinal Fluid as Potential Criteria for Definite Neuro-Behçet's Disease. [PDF]

open access: yesJ Clin Med, 2022
Belghith M   +8 more
europepmc   +1 more source

Geopolitical Risk and Food Inflation

open access: yesThunderbird International Business Review, Volume 68, Issue 2, Page 165-176, March/April 2026.
ABSTRACT This study investigates the complex relationship between geopolitical risk and food inflation, a critical issue for global food security. Using panel data from 177 countries from 2019 to 2021, the research employs a random effects estimation model to analyze the dynamic.
Izaete Leite Nogueira   +2 more
wiley   +1 more source

Shade‐induced transcriptional reprogramming and metabolic adaptation in contrasting soybean genotypes

open access: yesThe Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Shade stress affects soybean yield in intercropping, but the molecular basis of cultivar‐specific tolerance is unclear. We analyzed shade‐tolerant (Guru) and sensitive (Heinong 53) soybeans under 30% and 70% shade using transcriptomic, physiological, and biochemical methods.
Fengyi Zhang   +10 more
wiley   +1 more source

The Role of Polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 Genes in Non-Surgical Periodontal Therapy. [PDF]

open access: yesInt J Mol Sci, 2022
Walther KA   +11 more
europepmc   +1 more source

Fine mapping and functional analysis of the candidate gene OFP17, regulating both seed and fruit sizes in cotton

open access: yesThe Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Single cotton boll weight (BW) and seed index (SI, 100‐seed weight) are key determinants of lint and seed yield, yet their genetic basis remains poorly understood. Here, a stable interploidy introgression line with small boll from Gossypium arboreum in Gossypium hirsutum, NB298, was employed to map quantitative trait loci (QTLs) of BW and SI ...
Min Xu   +8 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

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