Results 11 to 20 of about 46,994 (248)

Reduced GATA3 expression associates with immuno‐metabolic alterations and aggressive features in breast cancer [PDF]

The Journal of Pathology: Clinical Research
In breast cancer (BC), the transcription factor GATA3 is linked to estrogen receptor (ER) alpha biology, and its loss is associated with aggressive tumor features.
Anna KM Sæle, Amalie A Svanøe, Cecilie Askeland, Gøril Knutsvik, Lise M Ingebriktsen, Rasmus OC Humlevik, Anette Heie, Turid Aas, Ingeborg Winge, Karin Collett, Ingunn M Stefansson, Erling A Hoivik, Lars A Akslen, Elisabeth Wik   +13 more
doaj   +2 more sources

A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression [PDF]

Molecular and Cellular Biology, 2018
Transcription factor GATA3 plays vital roles in inner ear development, while regulatory mechanisms controlling its inner ear-specific expression are undefined. We demonstrate that a cis-regulatory element lying 571 kb 3' to the Gata3 gene directs inner ear-specific Gata3 expression, which we refer to as the Gata3 otic vesicle enhancer (OVE).
Takashi, Moriguchi, Tomofumi, Hoshino, Arvind, Rao, Lei, Yu, Jun, Takai, Satoshi, Uemura, Kazue, Ise, Yasuhiro, Nakamura, Kim-Chew, Lim, Ritsuko, Shimizu, Masayuki, Yamamoto, James Douglas, Engel   +11 more
openaire   +2 more sources

GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas. [PDF]

PLoS ONE, 2016
Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients.We ...
Toshiaki Haraguchi, Hiroaki Miyoshi, Koji Hiraoka, Shintaro Yokoyama, Yukinao Ishibashi, Toshihiro Hashiguchi, Koutaro Matsuda, Tetsuya Hamada, Takahiro Okawa, Naoto Shiba, Koichi Ohshima   +10 more
doaj   +1 more source

The diagnostic utility of INSM1 and GATA3 in discriminating problematic medullary thyroid carcinoma, thyroid and parathyroid lesions

Polish Journal of Pathology, 2021
Discriminating thyroid and parathyroid lesions may sometimes pose a diagnostic difficulty. Medullary thyroid carcinomas (MTCs) display various cytologic and architectural features that resemble other thyroid and even rarely some parathyroid neoplasms ...
Sarah Adel Hakim, Nermine Mohamed Abd Raboh   +1 more
doaj   +1 more source

Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer [PDF]

Breast Cancer Research, 2014
Abstract Introduction GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function
Cohen, Helit, Ben-Hamo, Rotem, Gidoni, Moriah, Yitzhaki, Ilana, Kozol, Renana, Zilberberg, Alona, Efroni, Sol   +6 more
openaire   +2 more sources

Invasive micropapillary carcinoma of the breast and bilateral ovarian mature cystic teratoma with benign Brenner tumor in a postmenopausal woman – An uncommon occurrence

Indian Journal of Pathology and Microbiology, 2023
The synchronous occurrence of bilateral ovarian tumors and breast malignancy often raise the suspicion of a Krukenberg tumor or a hereditary breast and ovarian cancer syndrome, both of which are uncommon in clinical practice.
Pavithra Ayyanar, Suvradeep Mitra, Mohammed Imaduddin, Dillip K. Muduly   +3 more
doaj   +1 more source

Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]

, 2020
Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony, Horii, Mariko, Parast, Mana M, Touma, Ojeni   +3 more
core   +1 more source

GATA3 (GATA binding protein 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on GATA3 (GATA binding protein 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Tremblay, M, Bouchard, M
openaire   +2 more sources

GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3 [PDF]

Oncotarget, 2020
Recent evidence has implicated APOBEC3B (Apolipoprotein B mRNA editing enzyme catalytic subunit 3B) as a source of mutations in breast, bladder, cervical, lung, head, and neck cancers. However, the role of APOBEC3B in adrenocortical carcinoma (ACC) and the mechanisms through which its expression is regulated in cancer are not fully understood. Here, we
Gara, Sudheer Kumar, Tyagi, Monica Varun, Patel, Dhaval Thakkur, Gaskins, Kelli, Lack, Justin, Liu, Yi, Kebebew, Electron   +6 more
openaire   +2 more sources

Adrenal Gland Metastasis of Breast Invasive Mucinous Carcinoma: A Rare Case Report and Review of Literature

Case Reports in Oncology, 2022
The adrenal gland is a frequent site for metastasis, and the majority of the metastatic lesions of the adrenal gland normally originate from lung cancer, colon cancer, renal cell carcinoma, and melanoma.
Dingqi Sun, Jinhua Wang, Keqin Zhang, Hui Zhang, Tongxiang Diao, Qiang Fu   +5 more
doaj   +1 more source