Results 21 to 30 of about 46,994 (248)

Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways

Acta Pharmaceutica, 2022
Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The
Yu Li, Li Jianying
doaj   +1 more source

Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. [PDF]

, 2017
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and
Allard, Patrick, Chang, Kai-Wei, Chen, Hsin-Fu, Chou, Wen-Hsi, Ghelfi, Elisa, Ho, Hong-Nerng, Huang, Mei-Chi, Jan, Pey-Shynan, Lin, Shau-Ping, Lu, Chen-Yu, Wu, Chia-Eng, Wu, Fang-Chun, Yu, Chen-Wei   +12 more
core   +1 more source

Mutation of GATA3 in human breast tumors [PDF]

Oncogene, 2004
GATA3 is an essential transcription factor that was first identified as a regulator of immune cell function. In recent microarray analyses of human breast tumors, both normal breast luminal epithelium and estrogen receptor (ESR1)-positive tumors showed high expression of GATA3.
Jerry, Usary, Victor, Llaca, Gamze, Karaca, Shafaq, Presswala, Mehmet, Karaca, Xiaping, He, Anita, Langerød, Rolf, Kåresen, Daniel S, Oh, Lynn G, Dressler, Per E, Lønning, Robert L, Strausberg, Stephen, Chanock, Anne-Lise, Børresen-Dale, Charles M, Perou   +14 more
openaire   +2 more sources

The significance of GATA3 expression in breast cancer: a 10-year follow-up study. [PDF]

, 2009
GATA3 is a transcription factor closely associated with estrogen receptor alpha in breast carcinoma, with a potential prognostic utility. This study investigated the immunohistochemical expression of GATA3 in estrogen receptor alpha-positive and estrogen
Ciocca, Robin M, Ciocca, Vincenzo, Daskalakis, Constantine, Palazzo, Juan P, Ruiz-Orrico, Alejandra   +4 more
core   +2 more sources

GATA3 mutation disrupts a functional network governed by estrogen receptor, FOXA1 and GATA3 [PDF]

, 2019
AbstractEstrogen receptors (ER) are part of the nuclear receptor superfamily of transcription factors and are activated by the steroid hormone 17β-estradiol. ER forms a regulatory network in conjunction with other transcription factors, such as FOXA1 and GATA3.
Takaku, Motoki, Grimm, Sara A., Kumar, Bony De, Bennett, Brian D., Wade, Paul A.   +4 more
openaire   +1 more source

GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms [PDF]

Head and Neck Pathology, 2013
GATA3 is a zinc finger transcription factor that regulates the normal development of many tissues and cell types. Recent studies have shown that immunohistochemical nuclear staining for GATA3 among tumors is highly restricted to carcinomas of breast and urothelial origin; however salivary gland tumors have not been tested.
Lauren E, Schwartz, Shahnaz, Begum, William H, Westra, Justin A, Bishop   +3 more
openaire   +2 more sources

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

GATA3 expression in the solid cell nest of thyroid

Indian Journal of Pathology and Microbiology, 2020
Solid cell nest (SCN) of thyroid is a benign histomorphological mimicker of papillary microcarcinoma. Previous studies have elucidated a few immunohistochemical markers of SCN that aid in its distinction from papillary microcarcinoma.
Pavithra Ayyanar, Suvradeep Mitra, Suvendu Purkait   +2 more
doaj   +1 more source

GATA3 expression in triple‐negative breast cancers [PDF]

Histopathology, 2017
AimsGATA‐binding protein 3 (GATA3) is a well‐studied transcription factor found to be essential in the development of luminal breast epithelium and has been identified in a variety of tumour types, including breast and urothelial carcinomas, making it a useful immunohistochemistry marker in the diagnosis of both primary and metastatic disease.Methods ...
David J Byrne, Siddhartha Deb, Elena A Takano, Stephen B Fox   +3 more
openaire   +3 more sources

Metastatic Epithelial-Myoepithelial Carcinoma in a Female Presenting with Neck Mass and Lytic Lesion in Acetabulum: A Diagnostic Challenge on Cytology

Türk Patoloji Dergisi, 2021
Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant salivary neoplasm. Establishing an accurate cytological diagnosis is often challenging owing to its rarity, bland cytologic appearance and variable representation of cell ...
Parikshaa GUPTA, Arvind RAJWANSHI, Nandita KAKKAR   +2 more
doaj   +1 more source