Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles [PDF]
, 2007 The transcription factor Gata3 is crucially involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, what pathways are involved and how Gata3 differentially ...
Doorninck, J.H. (Hikke) van +4 more
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Auditory and Vestibular Phenotypes Associated With GATA3 Mutation [PDF]
Otology & Neurotology, 2014 To report the auditory and vestibular phenotypes of patients with GATA3 mutation.Case series of 6 patients.Tertiary referral center.All patients had the classic triad of GATA3 deficiency: hypoparathyroidism, hearing loss, and renal dysplasia. Patients (29-60 yr old; mean age, 42.5 yr; 3 male and 3 female subjects) were confirmed to have heterozygous ...
Wade Wei-De, Chien +6 more
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Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder
Zanco Journal of Medical SciencesBackground and objective: GATA3, an emerging immunohistochemical marker, is a zinc finger transcription factor that is expressed in normal urothelial epithelium and its corresponding neoplasms, and it has been recognized as a reliable urothelial related ...
Shadan Abdulkhaliq Jaf, Jalal Ali Jalal
doaj +1 more source
FLT3 mutations in Early T-Cell Precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors [PDF]
, 2013 Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults.
Baldus, Claudia D. +21 more
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Gata3 Is a Critical Regulator of Cochlear Wiring [PDF]
The Journal of Neuroscience, 2013 Spiral ganglion neurons (SGNs) play a key role in hearing by rapidly and faithfully transmitting signals from the cochlea to the brain. Identification of the transcriptional networks that ensure the proper specification and wiring of SGNs during development will lay the foundation for efforts to rewire a damaged cochlea.
Jessica M, Appler +5 more
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Continued expression of GATA3 is necessary for cochlear neurosensory development. [PDF]
PLoS ONE, 2013 Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for ...
Jeremy S Duncan, Bernd Fritzsch
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Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data. [PDF]
, 2014 Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year.
Bainbridge, Matthew N +3 more
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Cancer-specific mutation of GATA3 disrupts the transcriptional regulatory network governed by Estrogen Receptor alpha, FOXA1 and GATA3 [PDF]
Nucleic Acids Research, 2020 Abstract Estrogen receptors (ER) are activated by the steroid hormone 17β-estradiol. Estrogen receptor alpha (ER-α) forms a regulatory network in mammary epithelial cells and in breast cancer with the transcription factors FOXA1 and GATA3.
Paul A Wade +4 more
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Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]
, 2013 Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G. +9 more
core +5 more sources
Cellular networks controlling Th2 polarization in allergy and immunity [PDF]
, 2012 In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam +2 more
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