Results 61 to 70 of about 46,994 (248)

Gata3 antagonizes cancer progression in Pten-deficient prostates [PDF]

Human Molecular Genetics, 2013
Loss of the tumor suppressor PTEN is a common occurrence in prostate cancer. This aberration leads to the ectopic activation of the PI3K-Akt pathway, which promotes tumor growth. Here, we show that the transcription factor Gata3 is progressively lost in Pten-deficient mouse prostate tumors as a result of both transcriptional down-regulation and ...
Alana H T, Nguyen, Mathieu, Tremblay, Katharina, Haigh, Ismaël Hervé, Koumakpayi, Marilène, Paquet, Pier Paolo, Pandolfi, Anne-Marie, Mes-Masson, Fred, Saad, Jody J, Haigh, Maxime, Bouchard   +9 more
openaire   +2 more sources

The Role of GATA3 in Adipogenesis & Insulin Resistance [PDF]

University of the Future: Re-Imagining Research and Higher Education, 2020
Background: Impaired adipogenesis plays an important role in the development of obesityassociated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. In hyperglycemia, immune system is activated partially through upregulation of GATA3, causing exacerbation of the inflammatory state associated with ...
Al-Jaber, Hend Sultan, Al-Mansoori, Layla Jadea, ElRayess, Mohamed Aghar   +2 more
openaire   +2 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Barakat Syndrome in a Child: An Uncommon Cause of Hypocalcemic Tetany – A Case Report with Review of Literature

Indian Pediatrics Case Reports
Background: Barakat syndrome is a rare autosomal dominant disorder caused by mutations in the GATA3 gene, manifesting with a combination of hypoparathyroidism, sensorineural deafness, and renal dysplasia.
Subin Sabu, Vivek Dewan, Bharti Dhankhar, Vinay Kumar Mishra   +3 more
doaj   +1 more source

Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis

Cell Death and Disease, 2023
Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to their enrichment of cancer stem cells (CSCs). Breast CSCs can be generated from luminal-type cancer cells via epithelial-mesenchymal transition (EMT).
Xiong Liu, Feng Bai, Yuchan Wang, Chuying Wang, Ho Lam Chan, Chenglong Zheng, Jian Fang, Wei-Guo Zhu, Xin-Hai Pei   +8 more
doaj   +1 more source

Cell fate reprogramming by control of intracellular network dynamics

, 2014
Identifying control strategies for biological networks is paramount for practical applications that involve reprogramming a cell's fate, such as disease therapeutics and stem cell reprogramming.
Albert, Réka, Zañudo, Jorge G. T.
core   +3 more sources

Heterarchy of Transcription Factors Driving Basal and Luminal Cell Phenotypes in Human Urothelium [PDF]

, 2017
Cell differentiation is effected by complex networks of transcription factors that co-ordinate re-organisation of the chromatin landscape. The hierarchies of these relationships can be difficult to dissect. During in vitro differentiation of normal human
AA Mills, AL Sanborn, AP Boyle, Arianna Hustler, B Li, C Varley, C Varley, Carl Fishwick, CD Hurst, Chris D Greenman, CL Varley, CL Varley, CL Varley, David Swarbreck, DJ DeGraff, E Eden, ED Lobban, F Wezel, F Wezel, G Feil, G Kustatscher, H Heath, H Waki, J Dubois-Chevalier, J Feng, J Olsburgh, J Southgate, Janet Higgins, Jennifer Southgate, Joanna Pearson, JP Higgins, JR Mauney, JS Carroll, KJ Gaulton, L Ouboussad, L Song, LA Cirillo, Lawrence Percival-Alwyn, M Böck, M Dozmorov, M Lupien, M Murtha, M Werth, ME Reschen, MI Lefterova, MN Tran, N Soshnikova, NJ Smith, O Karni-Schmidt, P Eriksson, P Tontonoz, PG Giresi, PG Giresi, S Anders, S Heinz, S Rebouissou, S Riethdorf, Sarah Bastkowski, Simon Moxon, SM Bell, The Cancer Genome Atlas Research Network, TS Mikkelsen, TT Sun, V Theodorou, W Choi, W Choi, X Chen, Z Wu, Z Yu   +68 more
core   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

GATA3 Immunohistochemical Staining in Classical Hodgkin Lymphoma and Its Diagnostic Utility in Differential Diagnosis

Turkish Journal of Hematology
Objective: Classical Hodgkin lymphoma (CHL) is a common lymphoid neoplasm with a wide range of differential diagnoses. Although it has a specific immunophenotype, aberrant expression of antigens can cause problems at its diagnosis.
Ali Yılmaz Altay, Begüm Yeni, Gulcin Yegen   +2 more
doaj   +1 more source

Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control [PDF]

, 2019
The spinal cord contains a diverse array of interneurons that govern motor output. Traditionally, models of spinal circuits have emphasized the role of inhibition in enforcing reciprocal alternation between left and right sides or flexors and extensors ...
Bagnall, Martha W, Callahan, Rebecca A, Higashijima, Shin-Ichi, Kimura, Yukiko, Roberts, Richard, Sengupta, Mohini   +5 more
core   +1 more source