Results 51 to 60 of about 21,925 (161)

FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis

Brain Sciences, 2021
Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3
Concetta Scazzone, Luisa Agnello, Bruna Lo Sasso, Giuseppe Salemi, Caterina Maria Gambino, Paolo Ragonese, Giuseppina Candore, Anna Maria Ciaccio, Rosaria Vincenza Giglio, Giulia Bivona, Matteo Vidali, Marcello Ciaccio   +11 more
doaj   +1 more source

The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3 [PDF]

The Journal of Immunology, 2009
AbstractRecently, it was reported that the expression of Runt-related transcription factor 3 (Runx3) is up-regulated in CD4+ helper T cells during Th1 cell differentiation, and that Runx3 functions in a positive feed-forward manner with the T-box family transcription factor, T-bet, which is a master regulator of Th1 cell differentiation.
Kohu, K., Ohmori, H., Wong, W.F., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M., Satake, M.   +9 more
openaire   +3 more sources

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes

Scientific Reports, 2017
GATA3 is a transcription factor with an important role in atopic diseases because of its role in the differentiation of Th2 lymphocytes. Moreover, GATA3 is expressed in keratinocytes and has a role in keratinocyte differentiation and the establishment of
Jana Zeitvogel, Neele Jokmin, Samira Rieker, Ilona Klug, Christina Brandenberger, Thomas Werfel   +5 more
doaj   +1 more source

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells [PDF]

Immunity, 2014
Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
Yagi, Ryoji, Zhong, Chao, Northrup, Daniel L., Yu, Fang, Bouladoux, Nicolas, Spencer, Sean, Hu, Gangqing, Barron, Luke, Sharma, Suveena, Nakayama, Toshinori, Belkaid, Yasmine, Zhao, Keji, Zhu, Jinfang   +12 more
openaire   +2 more sources

Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. [PDF]

PLoS ONE, 2015
USP21 is a ubiquitin specific protease that catalyzes protein deubiquitination, however the identification of its physiological substrates remains challenging.
Jaspreet Pannu, Jad I Belle, Michael Förster, Claudia U Duerr, Shiyang Shen, Leanne Kane, Katherine Harcourt, Jörg H Fritz, Simon Clare, Anastasia Nijnik   +9 more
doaj   +1 more source

TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

Cell Reports, 2021
Summary: Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function, but its precise role in this setting remains unclear.
Rebecca Broome, Igor Chernukhin, Stacey Jamieson, Kamal Kishore, Evangelia K. Papachristou, Shi-Qing Mao, Carmen Gonzalez Tejedo, Areeb Mahtey, Vasiliki Theodorou, Arnoud J. Groen, Clive D’Santos, Shankar Balasubramanian, Anca Madalina Farcas, Rasmus Siersbæk, Jason S. Carroll   +14 more
doaj   +1 more source

Studying GATA3, FOXA1, and ELF5 transcription factors in the evaluation of prognosis in luminal breast cancer patients

Bulletin of Siberian Medicine, 2021
Background. The identification of predictive molecular markers of luminal breast cancer will help to assess the risk of developing distant metastases and determine a personalized approach to predicting the outcome of the disease during hormone therapy.The aim of the study was to investigate the relationship between the transcription factors GATA3 ...
S. V. Vtorushin, D. V. Vasilchenko, M. V. Zavyalova, N. V. Krakhmal’, S. V. Patalyak   +4 more
openaire   +3 more sources

Stage-specific GATA3 induction promotes ILC2 development after lineage commitment

Nature Communications
Group 2 innate lymphoid cells (ILC2s) are a subset of innate lymphocytes that produce type 2 cytokines, including IL-4, IL-5, and IL-13. GATA3 is a critical transcription factor for ILC2 development at multiple stages.
Hiroki Furuya, Yosuke Toda, Arifumi Iwata, Mizuki Kanai, Kodai Kato, Takashi Kumagai, Takahiro Kageyama, Shigeru Tanaka, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Akira Suto, Kotaro Suzuki, Hiroshi Nakajima   +13 more
doaj   +1 more source

GATA3 regulates Th1/Th2 balance in allergic rhinitis by interacting with RUNX1

Future Science OA
Objective To investigate the action mechanism of GATA3 and Runt-related transcription factor 1(RUNX1) in modulating regulatory the Th1/Th2 cell differentiation and treat allergic rhinitis (AR).Methods Established AR model mice by ovalbumin (OVA) and ...
Yuxiao Li, Tianrong Wang, Ming He, Yu Wang, Jiayan He   +4 more
doaj   +1 more source

Long noncoding RNA MEG3 inhibits oral squamous cell carcinoma progression via GATA3

FEBS Open Bio, 2023
Oral squamous cell carcinoma (OSCC) accounts for about 90% of oral cancers. Expression of the long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has previously been reported to be downregulated in OSCC, and its overexpression can inhibit ...
Yan Hu, Feifei Lv, Na Li, Xuewei Yuan, Liru Zhang, Shuangling Zhao, Linyu Jin, Yongle Qiu   +7 more
doaj   +1 more source