Results 21 to 30 of about 12,946 (215)

Molecular genetic analysis and clinical consideration of two families with GCK gene mutation [PDF]

Jichu yixue yu linchuang, 2020
Objective To explore the molecular genetics and clinical characteristics of two cases of maturity-onset diabetes of the young (MODY) type 2 caused by glucokinase (GCK) gene mutation.
WANG Zhi-xin, ZUO Qing-yao, LI Wei, CHEN Jia, DENG Wei
doaj   +1 more source

Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness [PDF]

International Journal of Endocrinology, 2013
Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited.
Stepanka Pruhova, Petra Dusatkova, Pavel J. Kraml, Michal Kulich, Zdena Prochazkova, Jan Broz, Jaroslav Zikmund, Ondrej Cinek, Michal Andel, Oluf Pedersen, Torben Hansen, Jan Lebl   +11 more
doaj   +2 more sources

Low prevalence of GCK gene mutations in Chinese patients with gestational diabetes mellitus. [PDF]

Clinics (Sao Paulo)
BACKGROUND AND AIM: Accumulating evidence suggests maturity onset diabetes of the young (MODY) caused by GCK gene mutations (GCK-MODY) is often misdiagnosed as Gestational Diabetes Mellitus (GDM) in pregnant women.
Wang Z, Huo L, Lan L, Chen Y, Zuo Q, Deng W.   +5 more
europepmc   +2 more sources

vr-lab-account/GCK-FLARE: GCK-FLARE

, 2023
<p>version 1.0</p ...
vr-lab-account
core   +1 more source

A Comprehensive Analysis of Hungarian MODY Patients—Part II: Glucokinase MODY Is the Most Prevalent Subtype Responsible for about 70% of Confirmed Cases

Life, 2021
MODY2 is caused by heterozygous inactivating mutations in the glucokinase (GCK) gene that result in persistent, stable and mild fasting hyperglycaemia (5.6–8.0 mmol/L, glycosylated haemoglobin range of 5.6–7.3%).
Zsolt Gaál, Zsuzsanna Szűcs, Irén Kántor, Andrea Luczay, Péter Tóth-Heyn, Orsolya Benn, Enikő Felszeghy, Zsuzsanna Karádi, László Madar, István Balogh   +9 more
doaj   +1 more source

Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease [PDF]

, 2011
The polymorphism, KLF6-IVS1-27A, in the Krüppel-like factor 6 (KLF6) transcription factor gene enhances its splicing into antagonistic isoforms and is associated with delayed histological progression of nonalcoholic fatty liver disease (NAFLD).
Gastaldelli, Amalia, Lee, Y., Isabel Fiel, Elisabetta Bugianesi, Miele, L., Lee, U., Bugianesi, E., Emma Buzzigoli, Andrea Mari, Pascoe, L., Mark Walker, Christopher P. Day, Burt, Alastair D., Walker, M., Bechmann, L., Hui, Kei Y, Fiel, I., Buzzigoli, E., Bechmann, Lars P., Miele, Luca, Fiel, Isabel., Luca Miele, Mari, Andrea, Patman, G., Ursula Muñoz, Day, Christopher P., Vetter, Diana., Burt, A., Lee, Young-Min., Munoz, Ursula., Hannivoort, Rebekka A., Alastair D. Burt, Amalia Gastaldelli, Walker, Mark., Agius, Loranne, Mari, A., Agius, Loranne., et al., Buzzigoli, Emma, Walker, Mark, Loranne Agius, Scott L. Friedman, Lee, Young-Min, Pascoe, Laura., Miele, Luca., Munoz, Ursula, Hui, K., Day, C., Laura Pascoe, Pascoe, Laura, Gastaldelli, Amalia., Fiel, Isabel, Ursula E. Lee, Gillian L. Patman, Munoz, U., Kei Y. Hui, Agius, L., Mari, Andrea., Vetter, D., Demetrio Ciociaro, Ciociaro, D., Buzzigoli, Emma., Lars P. Bechmann, Helen L. Reeves, Patman, Gillian L., Hannivoort, Rebekka A ., Ciociaro, Demetrio, Ciociaro, Demetrio., Mu?oz, Ursula, Bugianesi, Elisabetta, Diana Vetter, Reeves, Helen L., Hannivoort, R., Lee, Ursula E., Rebekka A. Hannivoort, Bugianesi, Elisabetta., Young-Min Lee, Vetter, Diana, Hui, Kei Y., Friedman, Scott L., Gastaldelli, A.   +80 more
core   +1 more source

An evolving spectrum of diabetes in a woman with GCK-MODY [PDF]

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Summary Coexistence of autoimmune diabetes and maturity-onset diabetes of the young (MODY) is rare. We report the first case of coexisting latent autoimmune diabetes of adulthood (LADA) and glucokinase (GCK) MODY. A 32-year-old woman was treated with insulin for gestational diabetes at age 32 years; post-partum, her fasting blood ...
Aoife Garrahy, Matilde Bettina Mijares Zamuner, Maria M Byrne   +2 more
openaire   +3 more sources

DataSheet1_GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY.docx

, 2023
Objective: Glucokinase-maturity-onset diabetes of the young (GCK-MODY; MODY2) is a rare genetic disorder caused by mutations in the glucokinase (GCK) gene.
Lifen Chen (3769015), Xiaoyu Ma (831683), Juanjuan Zhang (432819), Chuanyin Li (384935), Lin Li (28817), Wenli Lu (507310), Ronggui Hu (1828948), Ni Zhen (3774214), Caiping Zhang (6745976), Tongtong Dai (15138055), Zhiya Dong (10228241), Renqiao Tang (15138061), Yuan Xiao (304208), Sheng Lv (15138058), Yun Yang (417125)   +14 more
core   +1 more source

血糖控制较好的2型糖尿病患者β细胞葡萄糖激酶表达增加

Journal of Diabetes, 2023
Background Type 2 diabetes (T2D) is characterized by a progressive deterioration of β‐cell function with a continuous decline in insulin secretion. Glucokinase (GCK) facilitates the rate‐limiting step of glycolysis in pancreatic β‐cells, to acquire the ...
Jingwen Liu, Hui Fu, Fuyun Kang, Guang Ning, Qicheng Ni, Weiqing Wang, Qidi Wang   +6 more
doaj   +1 more source

A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting

Cell Reports, 2016
Glucose levels in mammals are tightly controlled through multiple mechanisms to meet systemic energy demands. Downregulation of hepatic glucokinase (GCK) during fasting facilitates the transition of the liver from a glucose-consuming to a gluconeogenic ...
Xiangbo Ruan, Ping Li, Andrew Cangelosi, Ling Yang, Haiming Cao   +4 more
doaj   +1 more source