Results 21 to 30 of about 13,098 (176)
MODY2 in Asia: analysis of GCK mutations and clinical characteristics
Endocrine Connections, 2020 Aims: Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2. Many patients with MODY2 in Asia have delayed timely treatment because they did not receive the correct diagn osis.
Yuan Zhou +4 more
doaj +1 more source
Evaluation of pregnancy outcomes in women with GCK-MODY
, 2021 Aims: To determine the fetal and maternal outcomes in pregnant women with Glucokinase-Maturity onset diabetes of the young (GCK-MODY). Methods: We studied the obstetric and perinatal outcomes in 99 pregnancies of 34 women with GCK-MODY.
Colclough, Kevin
core +1 more source
Journal of Diabetes, 2023 Background Type 2 diabetes (T2D) is characterized by a progressive deterioration of β‐cell function with a continuous decline in insulin secretion. Glucokinase (GCK) facilitates the rate‐limiting step of glycolysis in pancreatic β‐cells, to acquire the ...
Jingwen Liu +6 more
doaj +1 more source
Cell Reports, 2016 Glucose levels in mammals are tightly controlled through multiple mechanisms to meet systemic energy demands. Downregulation of hepatic glucokinase (GCK) during fasting facilitates the transition of the liver from a glucose-consuming to a gluconeogenic ...
Xiangbo Ruan +4 more
doaj +1 more source
, 2022 AimsGlucokinase–maturity-onset diabetes of the young (GCK-MODY) is the most common monogenic diabetes in China. We have previously reported on the low levels of high-sensitivity C-reactive protein (hsCRP) in patients with GCK-MODY.
Xinhua Xiao (486688) +2 more
core +1 more source
Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes
Disease Models & Mechanisms, 2018 High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and
Brian Lu +9 more
doaj +1 more source
Association of a homozygous GCK missense mutation with mild diabetes
Molecular Genetics & Genomic Medicine, 2019 Background Homozygous inactivating GCK mutations have been repeatedly reported to cause severe hyperglycemia, presenting as permanent neonatal diabetes mellitus (PNDM).
Antonella Marucci +8 more
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Chinese Medicine, 2021 Background Ginsenoside CK (GCK) serves as the potential anti-colorectal cancer (CRC) protopanaxadiol (PPD)-type saponin, which could be mainly bio-converted to yield PPD by gut microbiota.
Yin-Ping Guo +5 more
doaj +1 more source
Characterization of the interaction between GCK and BAD-GST.
, 2017 (A) Size-exclusion chromatogram of an equimolar mixture of BAD-GST and GCK (red) overlaid with BAD-GST (black) and GCK (blue) provides no evidence of complex formation.
Diego A. R. Zorio (748009) +2 more
core +1 more source
GCK‐MODY in pregnancy: A pregnant woman with diabetes and a small‐for‐gestational‐age fetus
, 2022 Glucokinase‐maturity‐onset diabetes of the young (GCK‐MODY) is often misdiagnosed as other forms of diabetes. A 42‐year‐old pregnant lady with pre‐existing diabetes was treated with insulin during first trimester. Fetal growth restriction was noted since
Stephanie Cheuk Yin Yu +4 more
core +1 more source