Results 31 to 40 of about 12,946 (215)

Humoral response markers in GCK MODY

Pediatric Endocrinology Diabetes and Metabolism, 2016
The prevalence of antibodies to pancreatic islets in monogenic diabetes remains unknown and the incidence estimation is difficult as the occurrence of autoantibodies in patient is one of the well-known exclusion criteria for further genetic diagnostics.
Eliza Skała-Zamorowska, Grażyna Deja, Borowiec, Maciej, Fendler, Wojciech, Małachowska, Beata, Halla Kamińska, Wyka, Krystyna, Młynarski, Wojciech, Przemysława Jarosz-Chobot   +8 more
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Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

Disease Models & Mechanisms, 2018
High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and
Brian Lu, Kiran Kurmi, Miguel Munoz-Gomez, Egon J. Jacobus Ambuludi, Jason M. Tonne, Kuntol Rakshit, Taro Hitosugi, Yogish C. Kudva, Aleksey V. Matveyenko, Yasuhiro Ikeda   +9 more
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GCK Gene Screening and Association of GCK Variants With Gestational Diabetes in North Indian Population [PDF]

Clinical Medicine Insights: Endocrinology and Diabetes, 2018
Background: GCK gene variants have been reported to be associated with gestational diabetes mellitus (GDM) in the Caucasian population. There are no reports exploring this association in the Indian population.
Samreen Siddiqui, Swati Waghdhare, Sundaramoorthy Gopi, Amit Bhargava, Manju Panda, Venkatesan Radha, Viswanathan Mohan, Shweta Dubey, Sujeet Jha   +8 more
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Neonatal outcome and diabetes course in children with GCK-MODY born from women with GCK-MODY

Pediatric Endocrinology Diabetes and Metabolism, 2018
Gestational diabetes is one of the most common medical disorders and may cause numerous of maternal and foetal complications, such as: preterm births, congenital defects, hypertrophic cardiomyopathy, metabolic changes, and macrosomia in neonates. One of the types of diabetes that may clinically manifest in pregnancy is GCK-MODY, caused by mutations in ...
Katarzyna, Kopacz-Petranyuk, Agnieszka, Brandt-Varma, Marta, Buraczewska, Anna, Wołoszyn-Durkiewicz, Jagoda, Peczyńska, Krzysztof, Preis, Przemysława, Jarosz-Chobot, Agnieszka, Szadkowska, Wojciech, Młynarski, Małgorzata, Myśliwiec   +9 more
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Prevalence of GCK mutations in individuals screened for fasting hyperglycaemia [PDF]

Diabetologia, 2008
Keywords Fastingplasmaglucose.Genetics.Glucokinase.MODY.PredictionAbbreviationsDHPLC denaturing high performance liquidchromatographyEDIT Early Intervention Diabetes TrialFHS Fasting Hyperglycaemia StudyGCK-MODY glucokinase MODY2HPGI 2-hour post-challenge plasma glucoseincrementTo the Editor: Glucokinase is a key enzyme that ...
Gloyn, A, van de Bunt, M, Stratton, I, Lonie, L, Tucker, L, Ellard, S, Holman, R   +6 more
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Capping Protein Interacts with GCK-1 and CCM-3 during C. elegans Zygote Cytokinesis [PDF]

, 2022
During cytokinesis, the remodeling of the actomyosin contractile ring separates a single cell into two daughter cells. The equatorial ring undergoes cortical remodeling and contraction, and the physical splitting of a single cell accurately partitions ...
Wan, Zixuan
core   +1 more source

Bioconversion variation of ginsenoside CK mediated by human gut microbiota from healthy volunteers and colorectal cancer patients

Chinese Medicine, 2021
Background Ginsenoside CK (GCK) serves as the potential anti-colorectal cancer (CRC) protopanaxadiol (PPD)-type saponin, which could be mainly bio-converted to yield PPD by gut microbiota.
Yin-Ping Guo, Li Shao, Li Wang, Man-Yun Chen, Wei Zhang, Wei-Hua Huang   +5 more
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Genetic counseling in monogenic diabetes GCK MODY

Pediatric Endocrinology Diabetes and Metabolism, 2016
Genetic testing in families with monogenic GCK MODY has predictive, diagnostic, and preventive utility. Predictive tests relate to people who have no features of the disorder themselves at the time of testing. Diagnostic tests relate to family members who have been previously diagnosed with diabetes mellitus or glucose metabolism disturbances.
Eliza, Skała-Zamorowska, Grażyna, Deja, Maciej, Borowiec, Wojciech, Fendler, Beata, Małachowska, Halla, Kamińska, Wojciech, Młynarski, Przemysława, Jarosz-Chobot   +7 more
openaire   +3 more sources

ANALYSIS OF MICRORNA EXPRESSION PATTERN IN SMALL INTESTINE OF CELIAC PATIENTS [PDF]

, 2010
Celiac disease (CD) is a chronic inflammatory disease characterized by small intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals following the dietary ingestion of gluten1.
Capuano, Marina
core   +1 more source

Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment

Molecular Genetics and Metabolism Reports, 2023
Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment.
Anne Cathrine Baun Thuesen, Rasmus Tanderup Jensen, Henrik Maagensen, Maja Refshauge Kristiansen, Henrik Toft Sørensen, Allan Vaag, Henning Beck-Nielsen, Oluf B. Pedersen, Niels Grarup, Jens Steen Nielsen, Jørgen Rungby, Anette Prior Gjesing, Heidi Storgaard, Tina Vilsbøll, Torben Hansen   +14 more
doaj   +1 more source