Results 41 to 50 of about 13,098 (176)

Optimization and validation of HTRF-based detection of the GCK-GKRP interaction.

, 2014
(A) Titration of GCK and GKRP. Results are presented as the ratio of the acceptor emission (665 nm) and donor emission (615 nm) for eight different GCK and GKRP concentrations measured at t = 60 minutes. Each data point is mean ± SEM for n = 6.
Min Shen (68726), Anna L. Gloyn (146286), Steve Titus (524536), Mindy I. Davis (105040), Anton Simeonov (85099), Anne Raimondo (524537), Francis S. Collins (82181), Matthew G. Rees (524535), Amy Barrett (166784)   +8 more
core   +1 more source

Gutter Rotation Technique for Percutaneous Ipsilateral Retrieval of a Ruptured SAPIEN‐3 Balloon

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Balloon rupture during transcatheter aortic valve replacement (TAVR) with balloon‐expandable valves is a rare but potentially serious complication that may result in incomplete valve expansion, difficult device retrieval, and vascular injury.
Anne Venkata Ganeshkumar, Guru Chaithanya Kumar Chagalakondu, Naveen Kumar Murki, Siva Sankara Kattinti, Sarat Surapaneni, Somaraju Bhupatiraju   +5 more
wiley   +1 more source

The Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway

Frontiers in Pharmacology, 2018
The imbalance between the GABA-mediated inhibition and the glutamate-mediated excitation is the primary pathological mechanism of epilepsy. GABAergic and glutamatergic neurotransmission have become the most important targets for controlling epilepsy ...
Xiangchang Zeng, Xiangchang Zeng, Kai Hu, Lulu Chen, Lulu Chen, Luping Zhou, Luping Zhou, Wei Luo, Wei Luo, Chaopeng Li, Chaopeng Li, Wenjing Zong, Wenjing Zong, Siyu Chen, Siyu Chen, Qing Gao, Qing Gao, Guirong Zeng, Dejian Jiang, Xiaohui Li, Xiaohui Li, Honghao Zhou, Honghao Zhou, Dong-sheng Ouyang, Dong-sheng Ouyang, Dong-sheng Ouyang   +25 more
doaj   +1 more source

Genetic and bioinformatics analysis of four novel GCK missense variants detected in Caucasian families with GCK-MODY phenotype.

, 2014
Heterozygous loss-of-function mutations in the glucokinase (GCK) gene cause maturity-onset diabetes of the young (MODY) subtype GCK (GCK-MODY/MODY2).
Contreas G, GIORGETTI, ALEJANDRO, MAFFEIS, Claudio, Costantini S, S. Costantini, G. Contreas, MALERBA, Giovanni, S.P. Marin Vargas, Marin Vargas, Sergio Paul, M. Corradi, C. Maffeis, G. Malerba, A. Giorgetti, CORRADI, Massimiliano   +13 more
core   +1 more source

A De Novo Whole GCK Gene Deletion Not Detected by Gene Sequencing, in a Boy with Phenotypic GCK Insufficiency [PDF]

, 2011
We report on a boy with diabetes mellitus and a phenotype indicating glucokinase (GCK) insufficiency, but a normal GCK gene examination applying direct gene sequencing. The boy was referred for diabetes mellitus at 7.5 years old.
N. H. Birkebæk, O. Pedersen, P. K. A. Jensen, T. Hansen, J. S. Sørensen, J. Vikre-Jørgensen   +5 more
core   +1 more source

Synthesis and characterization of polymer networks obtained by conventional radical and RAFT copolymerization processes in supercritical carbon dioxide

The Canadian Journal of Chemical Engineering, EarlyView.
Conventional and RAFT dispersion copolymerizations of HEMA and EGDMA in supercritical CO2 are compared in terms of swelling index (crosslink density), morphology, particle size distribution, and modular differential scanning calorimetry. Abstract The syntheses of net‐poly((2‐hydroxyethylene methacrylate)‐co‐(ethylene glycol dimethacrylate ...
Patricia Pérez‐Salinas, Karen Mozeltzin Gómez‐Cruz, Alberto Rosas‐Aburto, Maribel Pineda‐Herrera, Humberto Vázquez‐Torres, Graeme Moad, Eduardo Vivaldo‐Lima   +6 more
wiley   +1 more source

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. [PDF]

, 2009
Systemic inflammation arising from the organismal distribution of pathogen-associated molecular patterns is a major cause of clinical morbidity and mortality. Herein we report a critical and previously unrecognized in vivo role for germinal center kinase
Kyriakis, John M, Molnár, Arpád, L. Murray, S. Garafalo, J. Zhong, A. R. Simon, Gavrilescu, L Cristina, Kehrl, John H, J. H. Kehrl, Garafalo, Stephen, J. M. Kyriakis, Simon, Amy R, Van Etten, Richard A, A. Molnar, L. C. Gavrilescu, R. A. Van Etten, Zhong, Jian, Murray, Lauren   +17 more
core   +2 more sources

Evolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR).

PLoS ONE, 2013
BackgroundGlucokinase (GCK) plays an important role in the regulation of carbohydrate metabolism. In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis.
Zhao Yang Wang, Ling Jin, Huanran Tan, David M Irwin   +3 more
doaj   +1 more source

GCK‐MODY、HNF1A‐MODY和2型糖尿病的基础辅助检查的见解:一项系统回顾和meta分析

Journal of Diabetes, 2023
Background Glucokinase maturity‐onset diabetes of the young (GCK‐MODY) is difficult to distinguish from other diabetic forms. This article aims to characterize the differences in results from routine examinations between GCK‐MODY and hepatocyte nuclear ...
Jing Liu, Xinhua Xiao, Qian Zhang, Miao Yu   +3 more
doaj   +1 more source

Proportions and correlates of high‐risk cannabis use in Australia—A cross‐sectional analysis of the 2022–2023 National Drug Strategy Household Survey

Addiction, EarlyView.
Abstract Background and aim Cannabis use is prevalent in Australia, however, limited research has explored the levels of high‐risk cannabis use within nationally representative samples. This study aimed to address this gap by examining the proportion of individuals meeting criteria for high‐risk cannabis use and identifying its correlates in a ...
Janni Leung, Daniel Stjepanović, Gary Chung Kai Chan, Wayne Denis Hall, Danielle Dawson   +4 more
wiley   +1 more source