Results 61 to 70 of about 13,098 (176)

HbA1c increases with age in both GCK and controls.

, 2013
GCK indicated by black circles and black line, controls indicated by white circles and dashed line.
Kirsty J. Wensley (422228), Sian Ellard (25182), Beverley M. Shields (146725), Rinki Murphy (422229), Maggie Shepherd (422230), Anna M. Steele (422227), Andrew T. Hattersley (146736), Kevin Colclough (422231)   +7 more
core   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Monogenic Diabetes: Genetic Insight and Precision Therapeutics in the Management of MODY

Exon
A monogenic diabetes, specifically, the Maturity-onset diabetes of the young (MODY) is the consequence of the single-gene mutations that are responsible for transcription factors such as HNF1A and GCK taking effect on the insulin synthesis, glucose ...
Gayathri Venkatesan, Kala vetha Kumari, Ariya S S, Princy Vijayababu   +3 more
doaj   +1 more source

The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation

, 2010
Ste20 kinases constitute a large family of serine/threonine kinases with a plethora of biological functions. Members of the GCK-VI subfamily have been identified as important regulators of osmohomeostasis across species functioning upstream of ion ...
Kupinski, A., Thomas Müller-Reichert, Christian R. Eckmann, Eckmann, C., Müller-Reichert, T., Adam P. Kupinski   +5 more
core   +1 more source

Glycaemic Management and Pregnancy Outcomes in HNF1A‐MODY

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Birthweight of HNF1A‐affected offspring is largely similar to the background population with rarely reported cases of large for gestational age (LGA) and neonatal hypoglycaemia (NH). Conventional clinical management of pre‐gestational diabetes appears to be sufficient in managing HNF1A‐affected women in pregnancy.
M. T. Crowley, P. McCluskey, N. Ng, B. Sanchez‐Lechuga, A. Fleming, M. Hatunic, B. Kinsley, S. Bacon, K. Colclough, M. Kennelly, M. M. Byrne   +10 more
wiley   +1 more source

In vivo pharmacokinetics of ginsenoside compound K mediated by gut microbiota.

PLoS ONE
Ginsenoside Compound K (GCK) is the main metabolite of natural protopanaxadiol ginsenosides with diverse pharmacological effects. Gut microbiota contributes to the biotransformation of GCK, while the effect of gut microbiota on the pharmacokinetics of ...
Ming-Si Deng, Su-Tian-Zi Huang, Ya-Ni Xu, Li Shao, Zheng-Guang Wang, Liang-Jian Chen, Wei-Hua Huang   +6 more
doaj   +1 more source

Incidence of HNF1A and GCK MODY Variants in a South African Population

The Application of Clinical Genetics, 2020
Tandi E Matsha,1,* Shanel Raghubeer,1,* Abegail M Tshivhase,1 Saarah FG Davids,1 Gloudina M Hon,1 Lise Bjørkhaug,2 Rajiv T Erasmus1 1SAMRC/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health & Wellness ...
Matsha TE, Raghubeer S, Tshivhase AM, Davids SFG, Hon GM, Bjørkhaug L, Erasmus RT   +6 more
doaj  

Genetic basis of Asian diabetes

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Recent genomic studies in Asian populations have advanced our understanding of the diagnosis, pathophysiology, risk prediction, and precision care of diabetes. Monogenic diabetes, including maturity‐onset diabetes of the young (MODY) and mitochondrial diabetes, highlights the importance of genetic diagnosis for subtype‐specific care.
Takafumi Ojima, Toshimasa Yamauchi
wiley   +1 more source

Genetic Landscape and Diagnostic Challenges of MODY: A Comprehensive Review of Etiology, Subtypes, and Future Perspectives

Hamidiye Medical Journal
Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal-dominant form of diabetes. Because of the phenotypic overlap with other types of diabetes, MODY remains difficult for clinicians to diagnose; many cases are misdiagnosed as type 1 or ...
Şerife Serra Şen, Ethem Egemen Daban, Abdullah Cahid Kulaklıoğlu, Eren İdgö, Metin Eser, Gulam Hekimoğlu   +5 more
doaj   +1 more source

Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia.

PLoS ONE, 2012
Heterozygous glucokinase (GCK) mutations cause a subtype of maturity-onset diabetes of the young (GCK-MODY). Over 600 GCK mutations have been reported of which ∼65% are missense.
Lucia Valentínová, Nicola L Beer, Juraj Staník, Nicholas D Tribble, Martijn van de Bunt, Miroslava Hučková, Amy Barrett, Iwar Klimeš, Daniela Gašperíková, Anna L Gloyn   +9 more
doaj   +1 more source