Results 61 to 70 of about 12,946 (215)
Addiction, EarlyView.Abstract Aims To systematically review the evidence on the psychometric performance and accuracy of screening or diagnostic tools for cannabis use disorder. Method Systematic review and meta‐analysis which included studies conducted in clinical settings, schools, universities, community settings and population‐based surveys in multiple countries and ...
Janni Leung +8 more
wiley +1 more source
PLoS ONE, 2014 Recent genetic and clinical evidence has implicated glucokinase regulatory protein (GKRP) in the pathogenesis of type 2 diabetes and related traits. The primary role of GKRP is to bind and inhibit hepatic glucokinase (GCK), a critically important protein
Matthew G Rees +8 more
doaj +1 more source
Validating the Gaming Disorder Identification Test in English, Chinese, Dutch and Indonesian
Addiction, EarlyView.Abstract Background and aims Gaming disorder has been formally recognised in the International Classification of Diseases, 11th Revision (ICD‐11), but purpose‐designed and internationally validated screening tools remain limited. We aimed to assess the psychometric properties of the Gaming Disorder Identification Test (GADIT) to screen for past 12 ...
Gary Chung Kai Chan +12 more
wiley +1 more source
Biochemistry and Biophysics Reports, 2019 Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell death. However, the mechanism of β-cell death in GCK-HH remains poorly understood.
Brian Lu +3 more
doaj +1 more source
Distinguishing the lipid profile of GCK-MODY patients and its correlation with hsCRP levels
Frontiers in Endocrinology, 2022 AimsGlucokinase–maturity-onset diabetes of the young (GCK-MODY) is the most common monogenic diabetes in China. We have previously reported on the low levels of high-sensitivity C-reactive protein (hsCRP) in patients with GCK-MODY.
Fan Ping, Junling Fu, Xinhua Xiao
doaj +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
, 2022 AimsGlucokinase–maturity-onset diabetes of the young (GCK-MODY) is the most common monogenic diabetes in China. We have previously reported on the low levels of high-sensitivity C-reactive protein (hsCRP) in patients with GCK-MODY.
Xinhua Xiao (486688) +2 more
core +1 more source
PLoS ONE, 2017 The glycolytic enzyme glucokinase (GCK) and the pro-apoptotic protein BAD reportedly reside within a five-membered complex that localizes to the mitochondria of mammalian hepatocytes and pancreatic β-cells.
Alix Rexford +2 more
doaj +1 more source
Genetic basis of Asian diabetes
Journal of Diabetes Investigation, EarlyView.ABSTRACT Recent genomic studies in Asian populations have advanced our understanding of the diagnosis, pathophysiology, risk prediction, and precision care of diabetes. Monogenic diabetes, including maturity‐onset diabetes of the young (MODY) and mitochondrial diabetes, highlights the importance of genetic diagnosis for subtype‐specific care.
Takafumi Ojima, Toshimasa Yamauchi
wiley +1 more source
Monogenic Diabetes: Genetic Insight and Precision Therapeutics in the Management of MODY
ExonA monogenic diabetes, specifically, the Maturity-onset diabetes of the young (MODY) is the consequence of the single-gene mutations that are responsible for transcription factors such as HNF1A and GCK taking effect on the insulin synthesis, glucose ...
Gayathri Venkatesan +3 more
doaj +1 more source