Results 71 to 80 of about 13,098 (176)

Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension ...
Zachary Bloomgarden
wiley   +1 more source

Adrenal hormones in the maintenance of glucose homeostasis during prolonged fasting in male glucagon‐deficient mice

Journal of Diabetes Investigation, EarlyView.
Compensatory corticosterone‐mediated lipolysis and hepatic gluconeogenesis (via amino acids and glycerol) prevent hypoglycemia in GCGKO mice during prolonged fasting. ABSTRACT Aims/Introduction Glucagon is a key regulator of fasting glucose homeostasis, but the contribution of adrenal hormones during prolonged fasting remains unclear.
Sayumi Kanie, Koki Nishida, Yusuke Seino, Shihomi Hidaka, Shinji Ueno, Hiroaki Sumioki, Eisuke Tomatsu, Takuya Haraguchi, Naoya Murao, Haruki Fujisawa, Takeshi Takayanagi, Yoshihisa Sugimura, Yoshitaka Hayashi, Atsushi Suzuki   +13 more
wiley   +1 more source

GCK inhibition enhances iberdomide antimyeloma effects by promoting IKZF1 degradation via a CRBN-independent mechanism

Blood Neoplasia
: Our recent study identifies germinal center kinase (GCK) as a novel therapeutic target in RAS-mutated multiple myeloma (MM). Inhibiting GCK downregulates critical transcriptional factors, notably IKZF1/3, BCL-6, and c-MYC proteins, leading to MM cell ...
Shirong Li, Josefine Krüger, Guifen Liu, Huihui Ma, Michael S. Hughes, Rajshekhar Chakraborty, Divaya Bhutani, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch, Jing Fu   +10 more
doaj   +1 more source

Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase.

PLoS Biology, 2012
Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity-onset diabetes of the ...
Mioara Larion, Roberto Kopke Salinas, Lei Bruschweiler-Li, Brian G Miller, Rafael Brüschweiler   +4 more
doaj   +1 more source

Hypoglycemic response to dorzagliatin in a patient with GCK-MODY

OBJECTIVEMetformin, insulin, and insulin secretagogues do not alter HbA1c levels in glucokinase-maturity-onset diabetes of the young (GCK-MODY). However, the efficacy of the new hypoglycemic drugs on GCK-MODY remains unclear.RESEARCH DESIGN AND METHODSWe
Tianhao Ba (14802617), Yumin Ma (9740452), Qian Ren (230930), Linong Ji (131708), Xueyao Han (319175), Yilin Zhao (487866)   +5 more
core   +1 more source

Phenomic prediction of club wheat milling yields

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Near‐infrared reflectance spectroscopy (NIRS) provides a nondestructive method for estimating physical and chemical grain properties and is widely used in breeding programs to phenotype traits such as texture, color, moisture, protein, and oil content. Club wheat (Triticum aestivum subsp.
Peter Schmuker, Alecia Kiszonas, Sheri Rynearson, Kim Garland‐Campbell, Michael Pumphrey   +4 more
wiley   +1 more source

The First Case of Digenic MODY Diabetes Involving Compound Heterozygosity of Three Variants in the PDX1 and HNF1B Genes

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
A history of a woman diagnosed with diabetes at 15 led to the discovery of the first digenic MODY with compound heterozygosity of three variants in the PDX1 and HNF1B genes and family cascade screening. This underscores the importance of next‐generation sequencing in the differential diagnosis of diabetes type and extra‐pancreatic abnormalities ...
Magdalena Płonka‐Stępień, Magdalena Szopa, Magdalena Zawada, Maciej T. Malecki   +3 more
wiley   +1 more source

Atypical phenotype associated with reported GCK exon 10 deletions: Clinical judgement is needed alongside appropriate genetic investigations.

, 2016
BACKGROUND: Maturity-onset diabetes of the young (MODY) caused by heterozygous mutations in the glucokinase (GCK) gene typically presents with lifelong, stable, mild fasting hyperglycaemia.

core   +1 more source

Role of TRAF2/GCK in Melanoma Sensitivity to UV-Induced Apoptosis [PDF]

, 2000
Radiation resistance is a hallmark of human melanoma, and yet mechanisms underlying this resistance are not well understood. We recently established the role of ATF2 in this process, suggesting that stress kinases, which contribute to regulation of ATF2 ...
Ivanov, Vladimir N., Ronai, Ze'ev, Kehrl, John H.   +2 more
core   +1 more source

A comparison of daily glucose fluctuation among GCK-MODY and type 2 diabetes using continuous glucose monitoring technology

, 2023
   Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits the unique clinical features of mild fasting hyperglycaemia. However, formal studies of its glucose excursion pattern in daily life in comparison with those with or ...
Tianhao Ba (14802617), Leili Gao (14802638), Siqian Gong (9740455), Fang Zhang (197215), Xiaomei Zhang (147359), Linong Ji (131708), Fang Lv (300995), Xiangqing Wang (2588506), Wei Liu (20030), Yumin Ma (9740452), Qian Ren (230930), Wenjia Yang (2865512), Ping Zhang (86495), Wuyan Pang (5219804), Rui Zhang (13940), Xueyao Han (319175), Xiuying Zhang (56160), Tianhao Ba, Xiangqing Wang, Fang Lv, Yumin Ma, Wuyan Pang, Wenjia Yang, Linong Ji, Qian Ren, Rui Zhang, Xiaomei Zhang, Ping Zhang, Fang Zhang, Siqian Gong, Xiuying Zhang, Xueyao Han, Leili Gao, Wei Liu   +33 more
core   +1 more source