Results 81 to 90 of about 12,946 (215)

Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase.

PLoS Biology, 2012
Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity-onset diabetes of the ...
Mioara Larion, Roberto Kopke Salinas, Lei Bruschweiler-Li, Brian G Miller, Rafael Brüschweiler   +4 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Fungicidal Efficacy of Leaf Extracts From Khaya senegalensis (Desr.) A. Juss. Irrigated With Agricultural Drainage Water and Treated With Some Fertilizer Types

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The extraction and analysis of K. senegalensis compounds for wood preservation. Air‐dried leaves are milled, soaked in ethanol, filtered, and concentrated into dried extracts. These extracts undergo HPLC for chemical profiling. The concentrated extract is applied to wood samples to test its antifungal activity, demonstrating its potential as a natural ...
Esraa A. M. Mohamed, Ahmed M. El‐Baha, Ahmed A. A. El‑Settawy, Nader D. Shetta, Abeer A. Mohamed, Mohamed Z. M. Salem   +5 more
wiley   +1 more source

GCK inhibition enhances iberdomide antimyeloma effects by promoting IKZF1 degradation via a CRBN-independent mechanism

Blood Neoplasia
: Our recent study identifies germinal center kinase (GCK) as a novel therapeutic target in RAS-mutated multiple myeloma (MM). Inhibiting GCK downregulates critical transcriptional factors, notably IKZF1/3, BCL-6, and c-MYC proteins, leading to MM cell ...
Shirong Li, Josefine Krüger, Guifen Liu, Huihui Ma, Michael S. Hughes, Rajshekhar Chakraborty, Divaya Bhutani, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch, Jing Fu   +10 more
doaj   +1 more source

Alterations in Human Milk Adiponectin, Leptin, Resistin, and microRNAs in Mothers With Gestational Diabetes Mellitus Compared With Healthy Controls: A Systematic Review and Network‐Based Analysis

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Gestational diabetes alters the adipose–mammary gland axis, changing human milk composition—notably reducing adiponectin and dysregulating miR‐148a, miR‐30b, let‐7a, and let‐7d, which target ADIPOQ, LEP, and RETN and are enriched in glucose homeostasis/insulin resistance pathways.
Zhijun Zhang, Maryam Davoudi, Amirreza Ghafourian, Parmida Dehghan, Mojde Ahmadi, Seyed Mohammad Ayyoubzadeh, Xiaolei Miao, Hamid Choobineh, Reza Afrisham   +8 more
wiley   +1 more source

Status and future of seed conservation of threatened plants in the post‐2020 era

PLANTS, PEOPLE, PLANET, Volume 8, Issue 5, Page 1763-1777, September 2026.
Ambitious targets have been set to backup seeds of threatened plants by the global strategy for plant conservation (GSPC), but it is unclear in how far these targets have been met and how seed collection should be organized to meet future challenges. Here, we provide an overview of the status of 44 countries in achieving seed conservation targets.
Andreas Ensslin, Adelaide Clemente, Udayangani Liu, Elke Zippel, Carla Pinto‐Cruz, Carolina Sanchez Romero, Simone Schneider, Agustí Agut Escrig, Charlotte Allender, Külli Annamaa, Marina Antic, Bertille Asset, Gianluigi Bacchetta, Oz Baranzani, Anamaria Barata, Philippe Bardin, Joze Bavcon, Anabela D. F. Belo, Marina Belovarska, Karim Benkhelifa, Christian Berg, Karl‐Georg Bernhardt, Marcin Beza, Kristina Bjureke, Sina Bohm, Peter Borgmann, Josep Borrell, Stéphane Buord, Jocelyne Cambecedes, Francesca Carruggio, Angelino Carta, Pedro Casimiro, Ted Chapman, Iveta Cicova, Regis Crisnaire, Antonia Cristaudo, Lucia De la Rosa, Maîte Delmas, Gergana Desheva, Valter Di Cecco, Luciano Di Martino, Katia Diadema, Lara Dixon, Denise Dostatny, Marie Duval, Roland K. Eberwein, Mikel Etxeberria‐Okariz, Caroline Favier, Nick Fenby, Mariana P. Fernandes, Inmaculada Ferrando‐Pardo, Pablo Ferrer, Noémie Fort, Luigi Forte, Catia F. Freitas, Agnese Gailite, Katarzyna Galej‐Ciwis, Rosa Maria Garcia, Ana Irene García‐del Bao, Catherine Gautier, Bronislovas Gelvonauskis, Gian Petro Giusso del Galdo, Miguel Angel González Pérez, Johan Gourvil, Luisa Gouveia, Thierry Helminger, Brais Hermosilla Lorenzo, Laetitia Hugot, Marko Hyvärinen, Ignac Janžekovič, Andreas König, Nikos Krigas, Emilio Laguna, Ludivine Lapébie, Denis Larpin, Maja Lazarević, Dikla Lifshitz, Vincent Lipa, Carlos Lobo, Ulrike Lohwasser, Sandrine Loriot, Sara Magrini, Francesca Mantino, Mauro Mariotti, Evi Matiatou, Lubomir Mendel, Marine Millet, Mari Miranto, Andrea Mondoni, Santiago Moreno Vázquez, Valeria Negri, Peter Nick, Maciej Niemczyk, Humberto Nobrega, Pawel Olejniczak, Małgorzata Pałucka, Katerina Papanastasi, Ioanna Papanikolaou, Miguel A. A. Pinheiro de Carvalho, Marco Porceddu, Sotirios Porevis, Peter Poschlod, Lorenzo Raggi, Sarmite Rancane, Leonid Rasran, Blanka Ravnjak, Stéphane Rivière, Axelle Roumier, Anna Rucińska, Felix Schlatti, Marco Schmidt, Guy‐Xavier Seznec, Manuela Sim‐Sim, Ana Luisa Soares, Nora Stoeckl, Silvia Strajeru, Gitana Stukeniene, Andrej Šušek, Andreas Titze, Sarah Trinder, Zlatina Tsvetanova, Theo Van Hintum, Nils Van Rooijen, Magdalena Vicens Fornés, Mariacristina Villani, Silvia Villegas, Fiona J. White, Sabine Zachago, Elena Zappa, Vince Zsigmond, Sandrine Godefroid   +130 more
wiley   +1 more source

Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.

PLoS ONE, 2013
AimsHaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia.
Anna M Steele, Kirsty J Wensley, Sian Ellard, Rinki Murphy, Maggie Shepherd, Kevin Colclough, Andrew T Hattersley, Beverley M Shields   +7 more
doaj   +1 more source

Sociodemographic Trends in Daily, Weekly and Less Than Weekly Cannabis Use in Australia

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
ABSTRACT Introduction In the Australian 2001–2013 National Drug Strategy Household Surveys (NDSHS), frequent cannabis use declined among higher socioeconomic groups while remaining stable among lower socioeconomic groups, suggesting a widening socio‐demographic gap.
Janni Leung, Gary Chung Kai Chan, Ruofan Zhang, Wayne D. Hall, Caitlin McClure‐Thomas   +4 more
wiley   +1 more source

Performance of Glow Fixation GoCheck Kids and 2WIN Photoscreeners and Retinomax to Uncover Hyperopia

Clinical Ophthalmology, 2020
Alexa H Levitt,1 Samuel J Martin,2 Robert W Arnold3 1Human and Organizational Development, Vanderbilt University, Nashville, TN, USA; 2Research Department, Alaska Blind Child Discovery, Anchorage, AK, USA; 3Alaska Blind Child Discovery, Alaska Children ...
Levitt AH, Martin SJ, Arnold RW
doaj  

A case of maturity‐onset diabetes of the young with a pathogenic HNF1A variant and a coexisting NEUROD1 variant

Journal of Diabetes Investigation, Volume 17, Issue 9, Page 1457-1466, September 2026.
ABSTRACT Aims/Introduction Maturity‐onset diabetes of the young (MODY) accounts for at least 1%–5% of diabetes cases and is usually caused by single gene variants. Accurate diagnosis of MODY is important for effective management, especially in young individuals who are lean and lack islet autoantibodies.
Tomofumi Takayoshi, Yushi Hirota, Kenji Sugawara, Aki Sugano, Mika Ohta, Takehito Takeuchi, Akane Yamamoto, Wataru Satake, Yutaka Takaoka, Wataru Ogawa   +9 more
wiley   +1 more source