Results 81 to 90 of about 13,098 (176)

Human β‐Cell Dedifferentiation and Diabetes

Journal of Diabetes, Volume 18, Issue 10, October 2026.
Human β‐cell dedifferentiation is inversely associated with HOMA‐β and occurs in Type 2 diabetes, Type 3c diabetes, and age‐related diabetes, potentially before hyperglycemia develops. Progressive loss of β‐cell identity is accompanied by dedifferentiation and transdifferentiation, suggesting that reversing these cell‐state changes may help restore ...
Jiajun Sun, Jinsook Son, Qidi Wang
wiley   +1 more source

Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.

PLoS ONE, 2013
AimsHaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia.
Anna M Steele, Kirsty J Wensley, Sian Ellard, Rinki Murphy, Maggie Shepherd, Kevin Colclough, Andrew T Hattersley, Beverley M Shields   +7 more
doaj   +1 more source

Glycemic and Renal Effects of SGLT2 Inhibitors in Monogenic Diabetes: A Real‐World National Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9633-9643, October 2026.
ABSTRACT Aims Evidence regarding the efficacy and safety of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in monogenic diabetes is limited. We evaluated real‐world metabolic, renal, and safety outcomes of SGLT2i therapy in adults with monogenic diabetes.
Estelle Audrain, Pierre Bel Lassen, Christine Bellanné‐Chantelot, Marie Christine Vantyghem, Hippolyte Dupuis, Tiphaine Vidal‐Trecan, Nicolas Chevalier, Danièle Dubois‐Laforgue, Sophie Lamothe, Camille Vatier, Orianne Villard, René Valéro, Claire Briet, Corinne Vigouroux, Cécile Ciangura, Chloé Amouyal   +15 more
wiley   +1 more source

Performance of Glow Fixation GoCheck Kids and 2WIN Photoscreeners and Retinomax to Uncover Hyperopia

Clinical Ophthalmology, 2020
Alexa H Levitt,1 Samuel J Martin,2 Robert W Arnold3 1Human and Organizational Development, Vanderbilt University, Nashville, TN, USA; 2Research Department, Alaska Blind Child Discovery, Anchorage, AK, USA; 3Alaska Blind Child Discovery, Alaska Children ...
Levitt AH, Martin SJ, Arnold RW
doaj  

Clinical, Laboratory and Genetic Characteristics of Children with GCK-MODY (MODY2): Report of Four Novel Variants in GCK Gene

Trends in Pediatrics, 2020
Objective: Maturity-Onset Diabetes of the Young (MODY) is the most common type of monogenic diabetes. Heterozygous inactivating variants in glucokinase (GCK) gene are related to MODY2 (GCK–MODY).
Mustafa Altan, Ayşe Anık, Nilay Tuğçe Işık Bayar, Gokay Bozkurt, Tolga Ünüvar, Ahmet Anık   +5 more
doaj   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, Volume 293, Issue 20, Page 5996-6010, October 2026.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Identification of a Novel beta-Cell Glucokinase (GCK) Promoter Mutation (-71G > C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans

, 2009
OBJECTIVE: Inactivating mutations in glucokinase (GCK) cause mild fasting hyperglycemia. Identification of a GCK mutation has implications for treatment and prognosis; therefore, it is important to identify these individuals.
Klimes, Iwar, Kate Wicks, Daniela Gašperíková, Gasperíková, Daniela, Wicks, Kate, Lucia Valentínová, Knight, Julian C, Jozef Michálek, Kevin Colclough, Barrow, Beryl A, Valentínová, Lucia, Eva Bereczková, Tribble, Nicolas D, Nadežda Mišovicová, Ellard, Sian, Barák, L'ubomir, Gloyn, Anna L, Beryl A. Barrow, Dobránsky, Radoslav, Staník, Juraj, Nicolas D. Tribble, Sian Ellard, Radoslav Dobránsky, Bereczková, Eva, Martijn van de Bunt, Hucková, Miroslava, Misovicová, Nadezda, Colclough, Kevin, Juraj Staník, Michálek, Jozef, van de Bunt, Martijn, Anna L. Gloyn, Julian C. Knight, Iwar Klimeš, Miroslava Hučková, L'ubomir Barák   +35 more
core   +1 more source

Exercise training does not mitigate high‐phosphate diet‐induced mitochondrial dysfunction in skeletal muscle in male mice

Physiological Reports, Volume 14, Issue 20, October 2026.
Abstract Inorganic phosphate consumption in adults is two‐to‐three‐fold higher than the recommended daily allowance due to its widespread use as a preservative and flavor enhancer in processed foods. We previously reported that 12 weeks of high‐phosphate diet (HPD) reduced VO2max and altered metabolic gene expression and mitochondrial dysfunction in ...
Hannah F. Sanders, Dominic W. Kolonay, Jade A. Blackwell, Jiaru Liu, Isabella R. Dobrski, Daniel A. Branch, Lucas A. Lefers, Benjamen H. Kern, Kedryn K. Baskin   +8 more
wiley   +1 more source

Characterization of the interaction between GCK and peptide analogs of the BAD BH3 domain.

, 2017
(A) GCK at concentrations up to 10 μM does not increase the fluorescence polarization of f-BH3; (B) Isotherms for the addition of phosphorylated BH3 peptide to GCK do not indicate an interaction.
Diego A. R. Zorio (748009), Brian G. Miller (110045), Alix Rexford (3737923)   +2 more
core   +1 more source

Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

, 2016
BACKGROUND/AIM: Glucokinase (GCK)-activating mutations cause persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI). GCK-PHHI patients have regulated insulin secretion and can usually be treated with diazoxide.

core   +1 more source