Results 101 to 110 of about 12,946 (215)
Parallel assay development strategy to interrogate recombinant GCK and GKRP.
, 2014 Human GCK and GKRP were affinity-purified using GST and FLAG tags, respectively. (A) FRET-based (HTRF) detection. Antibodies recognizing the affinity tags are conjugated to FRET donor and acceptor molecules.
Min Shen (68726) +8 more
core +1 more source
GCK mutations in Croatian MODY patients
, 2019 Introduction: Maturity onset diabetes of the young (MODY) is clinically and genetically heterogeneous group of diabetes inherited in autosomal dominant manner. It usually occurs in adolescence or young adulthood and accounts for at least 1-3% of all diabetes. GCK-MODY is one of four most common type of MODY with estimated prevalence of 1:1000.
Ljubić, Hana +5 more
openaire +3 more sources
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
Distribution of the GCK mutations.
, 2013 The structure of GCK in the closed form (PDB code: 1v4s) is shown as cyan and red ribbons that represent the small and large domain, respectively. Orange ribbons show the α13 helix. Yellow spheres are the mutation sites.
Gerardo Daniele (377929) +9 more
core +1 more source
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation. [PDF]
, 2010 Ste20 kinases constitute a large family of serine/threonine kinases with a plethora of biological functions. Members of the GCK-VI subfamily have been identified as important regulators of osmohomeostasis across species functioning upstream of ion ...
Kupinski, A. +8 more
core +1 more source
Сахарный диабет, 2018 Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy.
Natalia A. Zubkova +8 more
doaj +1 more source
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
Roles of Cytokinetic Ring Proteins GCK-1 and CCM-3 in the C. elegans Zygote
, 2019 Cancer often involves abnormalities at the cellular level, such as errors in cytokinesis, the physical partitioning of two daughter cells by means of an actomyosin contractile ring.
Doshi, Anusha
core +1 more source