Results 111 to 120 of about 12,946 (215)
HbA1c increases with age in both GCK and controls.
, 2013 GCK indicated by black circles and black line, controls indicated by white circles and dashed line.
Kirsty J. Wensley (422228) +7 more
core +1 more source
A novel genetic mutation in a Turkish family with GCK-MODY
, 2017 Glucokinase-maturity-onset diabetes of the young (GCK-MODY) is an autosomal dominantly inherited disease caused by heterozygous inactivating mutations in the glucokinase gene. It usually presents with mild fasting hyperglycemia. Here, we present an obese
Mengen E. +5 more
core +1 more source
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
Genome BiologyBackground Amino acid substitutions can perturb protein activity in multiple ways. Understanding their mechanistic basis may pinpoint how residues contribute to protein function.
Sarah Gersing +6 more
doaj +1 more source
Maturity-onset Diabetes of the Young (MODY): How Much Can We Detect?
Bezmiâlem ScienceObjective: This study aims to assess the characteristics of patients who underwent genetic analysis with suspicion of maturity-onset diabetes of the young (MODY). Methods: Forty patients who met the criteria of measurable serum fasting C-peptide levels,
Gökhan UYGUN, Akif AYAZ, Mustafa KANAT
doaj +1 more source
Characterization of the interaction between GCK and peptide analogs of the BAD BH3 domain.
, 2017 (A) GCK at concentrations up to 10 μM does not increase the fluorescence polarization of f-BH3; (B) Isotherms for the addition of phosphorylated BH3 peptide to GCK do not indicate an interaction.
Diego A. R. Zorio (748009) +2 more
core +1 more source
Impact of recombinant BAD and BAD BH3 peptides on GCK activity.
, 2017 GCK kinetic constants are unaffected by (A) phosphorylated BAD-GST or (B) a phosphorylated BH3 analog. (C) GCK activity is modestly stimulated by BAD-GST (black) or phosphorylated BAD-GST (purple) compared with GST (green) at glucose concentrations below
Diego A. R. Zorio (748009) +2 more
core +1 more source
Distribution of the selected GCK mutations.
, 2012 The structure of GCK in the active closed form is shown (PDB code: 1v4s); the small and large domains are drawn in cyan and red, respectively; glucose appears as a yellow stick. Mutation sites are shown as green or blue spheres.
Maria Angeles Navas (156822) +11 more
core +1 more source
Diagnosis and management of glucokinase monogenic diabetes in pregnancy: current perspectives
Diabetes, Metabolic Syndrome and Obesity, 2019 Victoria L Rudland1,21Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, NSW, Australia; 2Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, AustraliaAbstract: Glucokinase–maturity-onset diabetes of the young ...
Rudland VL
doaj