Results 91 to 100 of about 12,946 (215)
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
Up in the air: the hidden neurodevelopmental toll of prenatal exposure
The Journal of Physiology, EarlyView.
Chintan K. Gandhi
wiley +1 more source
Retinoids synergize with insulin to induce hepatic Gck expression. [PDF]
, 2009 Hepatic GK (glucokinase) plays a key role in maintaining glucose homoeostasis. Many stimuli regulate GK activity by controlling its gene transcription. We hypothesized that endogenous lipophilic molecules modulate hepatic Gck expression.
Chen, Guoxun
core
Optimization and validation of luminescence-based detection of the GCK enzymatic reaction.
, 2014 (A) The assay (pH 7.1) contained 5 mM glucose, 0.4 mM ATP, 2 µM S6P, and was terminated after 75 minutes. Each data point is mean ± SEM for n = 4. (B) Effect of GKRP modulators on the luminescence reaction. The reaction included 15 nM GCK and 15 nM GKRP (
Min Shen (68726) +8 more
core +1 more source
Prevalence of Retinopathy in Adult Patients with GCK-MODY and HNF1A-MODY
Experimental and Clinical Endocrinology & Diabetes, 2015 We aimed to assess the prevalence of diabetic retinopathy (DR) in adult patients with GCK-MODY and HNF1A-MODY in Poland and to identify biochemical and clinical risk factors associated with its occurrence.We examined 74 GCK mutation carriers, 51 with diabetes and 23 with prediabetes, respectively, and 63 patients with HNF1A-MODY.
Szopa, Magdalena +9 more
openaire +3 more sources
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Barbara Dehos (18465048) +9 more
core +1 more source
, 2023 Poster by Yasmin Abu Aqel (Hamad Bin Khalifa University), Racha Chouaib (Hamad Bin Khalifa University), Aldana I. Alnesf (Hamad Bin Khalifa University), Idil Ahmed (Hamad Bin Khalifa University), Gowher Ali (Hamad Bin Khalifa University), Ahmed K ...
Aldana I. Alnesf (15430061) +11 more
core +1 more source
Revista de la Sociedad Argentina de Diabetes, 2018 MODY is produced by alterations in genes related to pancreatic beta cell metabolism. Type 2 is produced by alterations in the GCK gene (glucokinase) being one of the most frequent and type 5 by alterations in the HNF1B gene (nuclear hepatic factor 1B ...
Alejandro De Dios +5 more
doaj +1 more source
Optimization and validation of HTRF-based detection of the GCK-GKRP interaction.
, 2014 (A) Titration of GCK and GKRP. Results are presented as the ratio of the acceptor emission (665 nm) and donor emission (615 nm) for eight different GCK and GKRP concentrations measured at t = 60 minutes. Each data point is mean ± SEM for n = 6.
Min Shen (68726) +8 more
core +1 more source
DIABETES MODY: WHEN THE PREVALENCE IS PROPORTIONAL TO SUSPECT
Revista de la Sociedad Argentina de Diabetes, 2018 Commonly diabetes mellitus is divided into two large groups: type 1 and type 2, both with complex etiologies that there is an interaction between multiple genetic and environmental factors.
Gabriela Krochik
doaj +1 more source