Results 51 to 60 of about 12,946 (215)

The Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway

Frontiers in Pharmacology, 2018
The imbalance between the GABA-mediated inhibition and the glutamate-mediated excitation is the primary pathological mechanism of epilepsy. GABAergic and glutamatergic neurotransmission have become the most important targets for controlling epilepsy ...
Xiangchang Zeng, Xiangchang Zeng, Kai Hu, Lulu Chen, Lulu Chen, Luping Zhou, Luping Zhou, Wei Luo, Wei Luo, Chaopeng Li, Chaopeng Li, Wenjing Zong, Wenjing Zong, Siyu Chen, Siyu Chen, Qing Gao, Qing Gao, Guirong Zeng, Dejian Jiang, Xiaohui Li, Xiaohui Li, Honghao Zhou, Honghao Zhou, Dong-sheng Ouyang, Dong-sheng Ouyang, Dong-sheng Ouyang   +25 more
doaj   +1 more source

Synthesis and characterization of polymer networks obtained by conventional radical and RAFT copolymerization processes in supercritical carbon dioxide

The Canadian Journal of Chemical Engineering, EarlyView.
Conventional and RAFT dispersion copolymerizations of HEMA and EGDMA in supercritical CO2 are compared in terms of swelling index (crosslink density), morphology, particle size distribution, and modular differential scanning calorimetry. Abstract The syntheses of net‐poly((2‐hydroxyethylene methacrylate)‐co‐(ethylene glycol dimethacrylate ...
Patricia Pérez‐Salinas, Karen Mozeltzin Gómez‐Cruz, Alberto Rosas‐Aburto, Maribel Pineda‐Herrera, Humberto Vázquez‐Torres, Graeme Moad, Eduardo Vivaldo‐Lima   +6 more
wiley   +1 more source

Assay for recombinant human GCK.

, 2013
A) A Glucose curve. All reactions were initiated in the presence of 0.12 mM ATP, 0.2 µg GCK and 0.3 µg CD39L2 in 150 µL assay buffer at room temperature and proceeded for 15 minutes.
Zhengliang L. Wu (346319)
core   +1 more source

Kinetic constants of human recombinant wild type-GCK and mutant β-cell GST-GCK fusion proteins.

, 2012
Data represent means ± SEM of 3 separate enzyme expressions each tested in duplicate. Note that the Hill coefficient (nH) and the relative activity index (Ia) are unit less.
Maria Angeles Navas (156822), Carmen Maria Garcia-Herrero (156767), Carla Carluccio (156778), Marina Capuano (156764), Adriana Franzese (156808), Lucia Sacchetti (156828), Arturo Cola (156796), Dario Iafusco (156803), Iolanda Coto (156790), Valentina Capobianco (156785), Adriana Zagari (156815), Nadia Tinto (156773)   +11 more
core   +1 more source

Evolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR).

PLoS ONE, 2013
BackgroundGlucokinase (GCK) plays an important role in the regulation of carbohydrate metabolism. In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis.
Zhao Yang Wang, Ling Jin, Huanran Tan, David M Irwin   +3 more
doaj   +1 more source

GCK‐MODY、HNF1A‐MODY和2型糖尿病的基础辅助检查的见解:一项系统回顾和meta分析

Journal of Diabetes, 2023
Background Glucokinase maturity‐onset diabetes of the young (GCK‐MODY) is difficult to distinguish from other diabetic forms. This article aims to characterize the differences in results from routine examinations between GCK‐MODY and hepatocyte nuclear ...
Jing Liu, Xinhua Xiao, Qian Zhang, Miao Yu   +3 more
doaj   +1 more source

Proportions and correlates of high‐risk cannabis use in Australia—A cross‐sectional analysis of the 2022–2023 National Drug Strategy Household Survey

Addiction, EarlyView.
Abstract Background and aim Cannabis use is prevalent in Australia, however, limited research has explored the levels of high‐risk cannabis use within nationally representative samples. This study aimed to address this gap by examining the proportion of individuals meeting criteria for high‐risk cannabis use and identifying its correlates in a ...
Janni Leung, Daniel Stjepanović, Gary Chung Kai Chan, Wayne Denis Hall, Danielle Dawson   +4 more
wiley   +1 more source

Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

Communications Biology
Glucokinase (GCK) is an essential enzyme for blood glucose homeostasis. Because of its importance in glucose metabolism, GCK is considered an attractive target for the development of antidiabetic drugs.
Nicole Schmitner, Sophie Thumer, Dominik Regele, Elena Mayer, Ines Bergerweiss, Christian Helker, Didier Y. R. Stainier, Dirk Meyer, Robin A. Kimmel   +8 more
doaj   +1 more source

Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY)

BMC Pediatrics, 2018
Background There is scarcity of information on the clinical features and genetics of glucokinase-maturity-onset diabetes of the young (GCK-MODY) in China.
Xiuzhen Li, Tzer Hwu Ting, Huiying Sheng, Cui Li Liang, Yongxian Shao, Minyan Jiang, Aijing Xu, Yunting Lin, Li Liu   +8 more
doaj   +1 more source

Molecular Diagnosis of Monogenic Diabetes and Clinical/Laboratory Features in Turkish Children

JCRPE, 2021
Objective:Monogenic diabetes is a heterogeneous disease that causes functional problems in pancreatic beta cells and hyperglycemia. The aim of this study was to determine the clinical and laboratory features, the admission characteristics and ...
Damla Gökşen, Ediz Yeşilkaya, Samim Özen, Yılmaz Kor, Erdal Eren, Özlem Korkmaz, Merih Berberoğlu, Gülay Karagüzel, Eren Er, Ayhan Abacı, Olcay Evliyaoğlu, Emine Demet Akbaş, Edip Ünal, Semih Bolu, Özlem Nalbantoğlu, Ahmet Anık, Meltem Tayfun, Muammer Büyükinan, Saygın Abalı, Gülay Can Yılmaz, Deniz Kör, Elif Söbü, Zeynep Şıklar, Recep Polat, Şükran Darcan   +24 more
doaj   +1 more source