Results 51 to 60 of about 13,098 (176)

Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

Communications Biology
Glucokinase (GCK) is an essential enzyme for blood glucose homeostasis. Because of its importance in glucose metabolism, GCK is considered an attractive target for the development of antidiabetic drugs.
Nicole Schmitner, Sophie Thumer, Dominik Regele, Elena Mayer, Ines Bergerweiss, Christian Helker, Didier Y. R. Stainier, Dirk Meyer, Robin A. Kimmel   +8 more
doaj   +1 more source

The psychometric properties of validated tools to assess cannabis use disorder: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Aims To systematically review the evidence on the psychometric performance and accuracy of screening or diagnostic tools for cannabis use disorder. Method Systematic review and meta‐analysis which included studies conducted in clinical settings, schools, universities, community settings and population‐based surveys in multiple countries and ...
Janni Leung, Daniel Stjepanovic, Stephanie Fong, Danielle Dawson, Giang Vu, Tesfa Yimer, Caitlin McClure‐Thomas, Wayne Denis Hall, Gary Chung Kai Chan   +8 more
wiley   +1 more source

Molecular Diagnosis of Monogenic Diabetes and Clinical/Laboratory Features in Turkish Children

JCRPE, 2021
Objective:Monogenic diabetes is a heterogeneous disease that causes functional problems in pancreatic beta cells and hyperglycemia. The aim of this study was to determine the clinical and laboratory features, the admission characteristics and ...
Damla Gökşen, Ediz Yeşilkaya, Samim Özen, Yılmaz Kor, Erdal Eren, Özlem Korkmaz, Merih Berberoğlu, Gülay Karagüzel, Eren Er, Ayhan Abacı, Olcay Evliyaoğlu, Emine Demet Akbaş, Edip Ünal, Semih Bolu, Özlem Nalbantoğlu, Ahmet Anık, Meltem Tayfun, Muammer Büyükinan, Saygın Abalı, Gülay Can Yılmaz, Deniz Kör, Elif Söbü, Zeynep Şıklar, Recep Polat, Şükran Darcan   +24 more
doaj   +1 more source

A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease.

PLoS ONE, 2014
Recent genetic and clinical evidence has implicated glucokinase regulatory protein (GKRP) in the pathogenesis of type 2 diabetes and related traits. The primary role of GKRP is to bind and inhibit hepatic glucokinase (GCK), a critically important protein
Matthew G Rees, Mindy I Davis, Min Shen, Steve Titus, Anne Raimondo, Amy Barrett, Anna L Gloyn, Francis S Collins, Anton Simeonov   +8 more
doaj   +1 more source

Identification of GCK - Monogenic diabetes (GCK-MODY) in gestational diabetes subjects – diagnostic and treatment approach: literature review. [PDF]

Background. Maturity-onset diabetes of the young (MODY) is an autosomal dominant diabetes caused by a single gene mutation, leading to early-onset pancreatic beta-cell dysfunction. Its non-specific symptoms often result in misdiagnosis.
Boguševičiūtė, Agnė,
core   +1 more source

Validating the Gaming Disorder Identification Test in English, Chinese, Dutch and Indonesian

Addiction, EarlyView.
Abstract Background and aims Gaming disorder has been formally recognised in the International Classification of Diseases, 11th Revision (ICD‐11), but purpose‐designed and internationally validated screening tools remain limited. We aimed to assess the psychometric properties of the Gaming Disorder Identification Test (GADIT) to screen for past 12 ...
Gary Chung Kai Chan, Daniel Stjepanović, John B. Saunders, Stephanie Fong, Anne Marije Kaag, Jiang Long, Caitlin McClure‐Thomas, Kristiana Siste, Wim van den Brink, Pim Widdershoven, Min Zhao, Na Zhong, Janni Leung   +12 more
wiley   +1 more source

Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in β-cells via ATP depletion

Biochemistry and Biophysics Reports, 2019
Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell death. However, the mechanism of β-cell death in GCK-HH remains poorly understood.
Brian Lu, Jason M. Tonne, Miguel Munoz-Gomez, Yasuhiro Ikeda   +3 more
doaj   +1 more source

Distinguishing the lipid profile of GCK-MODY patients and its correlation with hsCRP levels

Frontiers in Endocrinology, 2022
AimsGlucokinase–maturity-onset diabetes of the young (GCK-MODY) is the most common monogenic diabetes in China. We have previously reported on the low levels of high-sensitivity C-reactive protein (hsCRP) in patients with GCK-MODY.
Fan Ping, Junling Fu, Xinhua Xiao
doaj   +1 more source

Genotype‐Dependent Functional and Pharmacological Profiling of Rare GCK Variants Reveals Implications for Precision Management of Monogenic Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Rare GCK variants contribute to heterogeneous forms of monogenic diabetes, yet the molecular basis underlying their diverse functional consequences and pharmacological responsiveness remains incompletely understood. As glucokinase (GCK) serves as a central glucose sensor in pancreatic β‐cells and hepatocytes, defining the functional ...
Haoyu Bai, Jie Yu, Qiusha Zhu, Xue Zhou, Ting Xie, Tong Wang, Jing Ren, Chuhan Shao, Qian Zhang, Changhong Li, Xinhua Xiao   +10 more
wiley   +1 more source

Biochemical and biophysical investigations of the interaction between human glucokinase and pro-apoptotic BAD.

PLoS ONE, 2017
The glycolytic enzyme glucokinase (GCK) and the pro-apoptotic protein BAD reportedly reside within a five-membered complex that localizes to the mitochondria of mammalian hepatocytes and pancreatic β-cells.
Alix Rexford, Diego A R Zorio, Brian G Miller   +2 more
doaj   +1 more source