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RNA-seq profiles from grass carp tissues after reovirus (GCRV) infection based on singular and modular enrichment analyses

open access: yesMolecular Immunology, 2014
Hemorrhagic disease of the grass carp, Ctenopharyngodon idella, is a fatal disease in fingerlings and yearlings caused by a reovirus, GCRV. RNA-seq data from four diseased grass carp tissues (gill, intestine, liver and spleen) were obtained at 2 h before
Mijuan Shi, Rong Huang, Fukuan Du
exaly   +2 more sources
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Autophagy signaling pathway is a therapeutic target to inhibit GCRV replication

Aquaculture, 2022
Abstract Autophagy is an evolutionarily conserved process that is thought to be essential for maintaining physiological homeostasis. However, the role of autophagy in host immune defense against viruses was poorly understood in fish. In this study, we found that although GCRV infection induced autophagy, increasing autophagy level by rapamycin ...
Pengfei Chu, Libo He, Xiaojun Zhang
exaly   +2 more sources

Nucleophosmin 1a translocated from nucleus to cytoplasm and facilitate GCRV replication

Fish & Shellfish Immunology, 2023
To decipher the functional characterization of Nucleophosmin 1a (NPM1a) from grass carp (Ctenopharyngodon idellus) (CiNPM1a), its cDNA was cloned and bioinformatic analysis were conducted. The full-length cDNA sequence of CiNPM1a is 1732 bp, which encodes 307 amino acids.
Hao, Tang   +6 more
openaire   +2 more sources

Hsp90 Regulates GCRV-II Proliferation by Interacting with VP35 as Its Receptor and Chaperone

Journal of Virology, 2022
Identification of viral receptors has always been the research hot spot in virus research field as receptor functions at the first stage of viral infection, which can be designed as efficient antiviral drug targets. GCRV-II, the causative agent of the grass carp epidemic hemorrhagic disease, has caused tremendous losses in grass carp culture in China.
Lin Jiang   +4 more
openaire   +2 more sources

Detection of grass carp reovirus (GCRV) with monoclonal antibodies

Archives of Virology, 2013
Grass carp reovirus (GCRV) is a pathogen that causes hemorrhagic disease of grass carp. It is the most serious infectious disease of carp and causes serious losses of fingerlings of grass carp and black carp. In this study, a recombinant VP4, one of the viral core proteins, was constructed with a histidine tag and expressed at a high level in E.
Jing, Hongli   +7 more
openaire   +2 more sources

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