Results 161 to 170 of about 1,339 (193)

miR-2188-5p promotes GCRV replication by the targeted degradation of klf2a in Ctenopharyngodon idellus

Developmental & Comparative Immunology, 2023
Studies on host immunity evasion by aquatic viruses have largely focused on coding genes. There is accumulating evidence for the important biological functions of non-coding miRNAs in virus-host interactions. The regulatory functions of non-coding miRNAs in fish reovirus-host interactions remain unknown.
Yangyu Li, Liangming Chen, Yangyang Li, Ping Deng, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Rong Huang   +9 more
openaire   +2 more sources

RBX1 and RBX2 promote GCRV replication in grass carp (Ctenopharyngodon idella)

Fish & Shellfish Immunology
Cullin-RING ligases (CRLs) constitute the most diverse E3 ligase family in the ubiquitin-proteasome system, yet their antiviral roles in bony fish remain poorly understood. Here, we identify the catalytic cores of CRLs, the RING-box proteins RBX1 and RBX2, as key modulators of antiviral signaling in cyprinid fish.
Jianhua Feng, Yafang Wang, Wenji Huang, Dawei Xie, Yinghao Huang, Xinran Tao, Tiantian Zhang, Haixia Wu, Jun Zou, Junya Wang   +9 more
openaire   +2 more sources

Identification of lipidomic responses to GCRV infection in Ctenopharyngodon idellus kidney (CIK) cells

Aquaculture, 2021
Abstract Grass carp reovirus (GCRV) is a causing pathogen of grass carp hemorrhagic disease, whose outbreak often brings out a huge economic loss in aquaculture filed. Cellular lipids play crucial roles in many biological processes, such as virus replication, maturation and transmission. Presently, it remains to elucidate the roles of these lipids in
Xing Zhang, Jingcai Huang, Zeen Shen, Yan Wang, Yujun Wang, Chengliang Gong, Xiaolong Hu, Chonglong Wang   +7 more
openaire   +1 more source

Ctenopharyngodon idellus DDX41 initiates IFN I and ISG15 expression in response to GCRV infection

Fish & Shellfish Immunology, 2020
As a member of DExD/H-box helicase family, DDX41 (DEAD box polypeptide 41) acts as an intracellular DNA sensor that induces type I IFN expression in mammals. Fish DDX41 shares some similar properties with the mammalian counterparts. In this study, a DDX41 orthologous gene from grass carp (Ctenopharyngodon idellus) (CiDDX41) was cloned and characterized.
Jihuan, Hu, Xiaowen, Xu, Shanghong, Wang, Gang, Ge   +3 more
openaire   +2 more sources

IFNa of triploid hybrid of gold fish and allotetraploid is an antiviral cytokine against SVCV and GCRV

Fish & Shellfish Immunology, 2016
Triploid hybrid of gold fish (Carassius auratus red var., ♀, 2n = 100) and allotetroploid (♂, 2n = 100) displays much improved disease resistance than its parents. In this paper, one of the type I IFNs of triploid hybrid (3nIFNa) has been cloned and characterized.
Jun, Yan, Lingzhi, Peng, Yang, Li, Hui, Fan, Yu, Tian, Shaojun, Liu, Hao, Feng   +6 more
openaire   +2 more sources

The structural characteristics and expression characteristics of C1S in response to GCRV infection in grass carp

Fish & Shellfish Immunology
The complement system, a critical component of innate immunity in fish, plays a pivotal role in the defense against Grass Carp Reovirus (GCRV) infection in grass carp. This study explores the structural characteristics of C1S, a crucial molecule in the classical pathway of the complement system, and its involvement in the response to GCRV infection. We
Yuling Wei, Zhao Lv, Zongjun Du, Tiaoyi Xiao   +3 more
openaire   +2 more sources

IFNa2 of triploid hybrid of gold fish and allotetraploid is an intracellular antiviral cytokine against SVCV and GCRV

Fish & Shellfish Immunology, 2017
Sterile triploid hybrids (3n = 150) of gold fish (Carassius auratus red var., ♀, 2n = 100) and allotetroploid (♂, 2n = 100) display obviously improved disease resistance and much enhanced growth rate than their parents, which have been cultured widely in China.
Jun, Yan, Lingzhi, Peng, Mengdie, Chi, Jun, Xiao, Jun, Li, Shaojun, Liu, Hao, Feng   +6 more
openaire   +2 more sources

In Vitro and In Vivo Antiviral Activity of Histone Deacetylase Inhibitors Against GCRV

Journal of Fish Diseases
ABSTRACT Grass carp haemorrhagic disease (GCHD), a severe viral affliction caused by grass carp reovirus (GCRV), is responsible for significant mortality among grass carp. Characterised by rapid transmission and latent infections, GCHD poses a critical challenge in aquaculture.
Guangyao Hu, Feiran Li, Mengsha Zhou, Xiang Tian, Weijun Wu, Hao Wang, Liqun Lu   +6 more
openaire   +2 more sources

Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation

Research in Veterinary Science, 2018
Moroxydine hydrochloride (Mor) and ribavirin (Rib) are known for their multi-antiviral activities against DNA and RNA viruses but little information is available about the pharmacological impact in aquaculture. The present study was undertaken to investigate the response of host cells to antiviral compounds during the anti-GCRV treatment.
Xiao-Bo, Yu, Kai, Hao, Jing, Li, Xiao-Hui, Chen, Gao-Xue, Wang, Fei, Ling   +5 more
openaire   +2 more sources

CiLSM14Aa acts as a cytosolic dsRNA sensor to activate antiviral immunity against GCRV-II

Fish & Shellfish Immunology
The innate immune system relies on pattern recognition receptors (PRRs) to detect viral pathogens and initiate antiviral responses. LSM14A, a conserved RNA-binding protein involved in mRNA metabolism, has recently emerged as a cytosolic nucleic acid sensor in vertebrates. However, its role in teleost immunity remains unclear.
Hui Jiang, Chu Zhang, Pengfei Li, Yong-An Zhang, Xiangmou Qin   +4 more
openaire   +2 more sources