Results 121 to 130 of about 36,093 (252)
Thermodynamic characterisation of covalent ligand binding
British Journal of Pharmacology, EarlyView.Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman +4 more
wiley +1 more source
CD93—An emerging vascular target in cancer therapy
British Journal of Pharmacology, EarlyView.Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira +3 more
wiley +1 more source
GEF Funding Windows & Project Cycle Elements
GEF Funding Windows & Project Cycle Elements delivered during the Joint workshop on regional cooperation in Central Asia – Leveraging synergies for integrative land-biodiversity-climate action and development of the Peace Forest Initiative for land ...
Apel, Ulrich
core
Protected areas on international borders show uneven conservation outcomes
Conservation Biology, EarlyView.Abstract Border protected areas (BPAs) are national protected areas that are immediately adjacent to a country's border or span two or more countries; they are characterized by distinctive opportunities and pressures. They play a critical role in protecting carbon‐rich ecosystems, conserving endangered biodiversity, reducing cross‐border environmental ...
Rachakonda Sreekar +10 more
wiley +1 more source
Lack of Capacity: The Not‐So‐Hidden Factor Undermining Fisheries Governance
Fish and Fisheries, EarlyView.ABSTRACT The demand for marine resources is increasing, and an increasing number of fish stocks are fully or overexploited. To turn this downward projection around, states need to strengthen the effectiveness, equity and implementation of fisheries management measures.
Haas Bianca +2 more
wiley +1 more source
RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The FEBS Journal, EarlyView.The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source
Future Journal of Pharmaceutical SciencesBackground Conventional therapies in cancer treatment face challenges including drug resistance, lack of specificity, and severe adverse reactions. This study explores the potential of liposomal transdermal delivery systems as an alternative to current ...
Jyoti S. Patel +2 more
doaj +1 more source
The Journal of Cell Biology, 2003 Receptor tyrosine kinases (RTKs) that are bound to appropriate growth factors activate PI3K, which initiates Rac-induced cytoskeletal alterations. The signaling steps between PI3K and Rac are uncovered on page 17 in an article by Innocenti et al. that reveals the importance of complexes in activating guanine nucleotide exchange factors (GEFs).
openaire +2 more sources
Challenges And Opportunities In Managing Pollution In The East Asian Seas
, 1999 xlv;ill.;567hal ...
GEF/UNDP/IMO/PEMSEA
core
Crystal structure of tetrameric human Rabin8 GEF domain
, 2018 Rab GTPases and their effectors, activators and guanine nucleotide exchange factors (GEFs) are essential for vesicular transport. Rab8 and its GEF Rabin8 function in formation of the cilium organelle important for developmental signaling and sensory ...
Niels Boegholm +13 more
core +1 more source