Results 91 to 100 of about 5,291,226 (319)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Polymorphism detection of catalase-21A\T (rs 7943316) gene in chronic myeloid leukemia patients infected with human herpes virus-7

Iraqi Journal of Hematology
BACKGROUND: Chronic myeloid leukemia (CML) is a type of cancer that originates in hematopoietic stem cells, particularly those that develop into myeloid cells.
Yusur Falah Faraj
doaj   +1 more source

Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation [PDF]

, 2013
Kyong-Rim Kieffer-Kwon, Zhonghui Tang, Ewy A. Mathé, Jason Qian, Myong‐Hee Sung, Guoliang Li, Wolfgang Resch, Songjoon Baek, Nathanael Pruett, Lars Grøntved, Laura Vian, Steevenson Nelson, Hossein Zare, Ofir Hakim, Deepak Reyon, Arito Yamane, Hirotaka Nakahashi, Alexander L. Kovalchuk, Jizhong Zou, J. Keith Joung, Vittorio Sartorelli, Chia‐Lin Wei, Xiaoan Ruan, Gordon L. Hager, Yijun Ruan, Rafael Casellas   +25 more
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites [PDF]

, 2003
Damien Chaussabel, Roshanak Tolouei Semnani, Mary Ann McDowell, David L. Sacks, Alan Sher, Thomas B. Nutman   +5 more
openalex   +1 more source

Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity [PDF]

, 2022
Mathieu Quinodoz, Virginie G. Peter, Katarina Cisarova, Béryl Royer‐Bertrand, Peter D. Stenson, D.N. Cooper, Sheila Unger, Andrea Superti‐Furga, Carlo Rivolta   +8 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A rare intronic c.2654+1G>A mutation in CSF1R-microglial encephalopathy: a case report

Frontiers in Genetics
ObjectiveWe report a case of CSF1R-microglial encephalopathy associated with a rare intronic c.2654 + 1G>A mutation, featuring negative diffusion-weighted imaging (DWI) findings and a cerebrospinal fluid (CSF) biomarker profile indicative of Alzheimer’
HongYan Wu, JingYu Shi, XiaoShan Wang, Mei Yang, Jing Cai   +4 more
doaj   +1 more source

Actin-dependent intranuclear repositioning of an active gene locus in vivo [PDF]

, 2007
Miroslav Dundr, Jason K. Ospina, Myong‐Hee Sung, Sam John, Madhvi B. Upender, Thomas Ried, Gordon L. Hager, A. Gregory Matera   +7 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source