Results 91 to 100 of about 16,521,028 (347)
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis
Shanghai Jiaotong Daxue xuebao. Yixue banHeterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes,
ZHANG Zongwen, FENG Li, FAN Zhisong
doaj +1 more source
Antiprismless, or: Reducing Combinatorial Equivalence to Projective Equivalence in Realizability Problems for Polytopes [PDF]
, 2015 This article exhibits a 4-dimensional combinatorial polytope that has no antiprism, answering a question posed by Bernt Lindst\"om. As a consequence, any realization of this combinatorial polytope has a face that it cannot rest upon without toppling over.
Dobbins, Michael Gene
core
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Frontiers in ImmunologyObjectiveLung adenocarcinoma (LUAD) continues to be a primary cause of cancer-related mortality globally, highlighting the urgent need for novel insights finto its molecular mechanisms.
Binyu Wang +4 more
doaj +1 more source
Genes contributing to genetic variation of muscling in sheep
Frontiers in Genetics, 2012 Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat ...
Ross L Tellam +3 more
doaj +1 more source
Humoral immune responses to
, 2021 M. A. Whitehead +3 more
openalex +1 more source
Graph Laplacian Regularization for Image Denoising: Analysis in the Continuous Domain
, 2017 Inverse imaging problems are inherently under-determined, and hence it is important to employ appropriate image priors for regularization. One recent popular prior---the graph Laplacian regularizer---assumes that the target pixel patch is smooth with ...
Cheung, Gene, Pang, Jiahao
core +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The value of genome-wide analysis in craniosynostosis
Frontiers in GeneticsBackground: This study assessed the diagnostic yield of high-throughput sequencing methods in a cohort of craniosynostosis (CS) patients not presenting causal variants identified through previous targeted analysis.Methods: Whole-genome or whole-exome ...
Alexandra Topa +12 more
doaj +1 more source