Results 171 to 180 of about 8,130,594 (350)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The pattern of gene amplification of members of the Plasmodium vivax erythrocyte binding-like proteins family across the Amazon rainforest. [PDF]

Malar J
Guedes KS, Fernandes GM, Sanchez BAM, Ntumngia FB, Adams JH, Kano FS, Fontes CJF, de Sousa TN, Carvalho LH.   +8 more
europepmc   +1 more source

MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC. [PDF]

Thorac Cancer, 2022
Tyler LC, Le AT, Chen N, Nijmeh H, Bao L, Wilson TR, Chen D, Simmons B, Turner KM, Perusse D, Kasibhatla S, Christiansen J, Dudek AZ, Doebele RC.   +13 more
europepmc   +1 more source

Practical Teaching of Clinical Gene Amplification Testing in Laboratory Medicine Education: Experiences and Insights

Xianchun Meng, Shijie Zhang, Yuying Liu
openalex   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Glioblastoma with cerebrospinal fluid dissemination and MYC gene amplification: A transitional or atypical glioblastoma with primitive neuronal components. [PDF]

Medicine (Baltimore)
Zhang W, Lin L, Li Y, Wang Y, Shen H, Guan Y.   +5 more
europepmc   +1 more source

Electrochemical Gene Amplification Signal Detection of Disposable Biochips Using Electrodes. [PDF]

Sensors (Basel), 2022
Kim GR, Hwang JS, Kim JD, Kim YS, Park CY.   +4 more
europepmc   +1 more source

IncFII _k plasmid harbouring an amplification of 16S rRNA methyltransferase-encoding gene rmtH associated with mobile element IS CR2 [PDF]

, 2016
Racha Beyrouthy, Frédéric Robin, Monzer Hamzé, Richard Bonnet   +3 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

ZNF217 Gene Copy Number as a Marker of Response to Standard Therapy Drugs According to ERα Status in Breast Cancer

Breast Cancer: Targets and Therapy
Nelson Rangel,1 Iris Lorena Sánchez,2 Duván Sebastián Valbuena,2 Milena Rondón-Lagos2 1Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, 110231, Colombia; 2School of Biological Sciences, Universidad ...
Rangel N, Sánchez IL, Valbuena DS, Rondón-Lagos M   +3 more
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