Gene amplification - Open Access .click

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[6] Gene identification by exon amplification

1999
Publisher Summary For humans as well as other organisms with more complex genomes, development of maps provide a powerful tool in positional cloning efforts, but this is currently a daunting task. Whole-genome, chromosome-specific, and region-specific endeavors employ a variety of approaches that focus on characteristics that are common to most genes.
Deanna M. Church, Alan Buckler
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GENE AMPLIFICATION

Annual Review of Biochemistry, 1984
G R, Stark, G M, Wahl
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Gene Amplification in Dipteran Chromosomes

1987
The giant polytene chromosomes characteristic of many Dipteran cells allow fundamental nuclear processes occurring during development to be directly visualized. Polytene chromosomes afford a detailed picture of “large-scale” structures within developmentally regulated interphase cells — features extending over more than about 5–10 kb of chromosomal DNA.
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The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification