Results 211 to 220 of about 8,013,600 (393)

Structure of DNA formed in the first step of CAD gene amplification. [PDF]

, 1986
Elena Giulotto, Izumu Saito, George R. Stark   +2 more
openalex   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways. [PDF]

Virus Evol, 2022
Banerjee S, Smith C, Geballe AP, Rothenburg S, Kitzman JO, Brennan G.   +5 more
europepmc   +2 more sources

Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor. [PDF]

Gynecol Oncol, 2023
McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich TMP, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa MSZ, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Burton EA, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin AD.   +28 more
europepmc   +1 more source

DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.

, 1985
W. L. WASHTIEN, Raelene J. Grumont, Daniel V. Santi   +2 more
openalex   +1 more source

Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. [PDF]

, 1985
Donna L. George, Alan F. Scott, Stephen P. Trusko, B.R. Glick, E. B. Ford, D J Dorney   +5 more
openalex   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

p53 aberration and TFE3 gene amplification may be predictors of adverse prognosis in epithelioid angiomyolipoma of the kidney. [PDF]

Diagn Pathol, 2023
Zhang Y, Wei X, Teng X, Chen G.
europepmc   +1 more source

Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea. [PDF]

, 1983
Robert M. Snapka, Alexander Varshavsky
openalex   +1 more source

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

Cell, 2014
M. Tanenbaum, Luke A. Gilbert, Lei S. Qi, J. Weissman, R. Vale   +4 more
semanticscholar   +1 more source