Results 61 to 70 of about 8,130,594 (350)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Identification of Conserved Repetitive Amino Acid Motifs in Antifreeze Proteins of Selected Helopini Species (Coleoptera: Tenebrionidae)

Cumhuriyet Science Journal
Antifreeze proteins (AFP) protect the organisms against freezing by increasing freezing tolerance. Insects inhabiting cold regions have been reported to utilize AFPs as part of their cold adaptation mechanisms.
Duygu Kan, Bekir Keskin
doaj   +1 more source

Investigating the mechanisms of glyphosate resistance in goosegrass (Eleusine indica) population from South China

Journal of Integrative Agriculture, 2015
Glyphosate has been used worldwide for nearly 40 years, and 30 types of resistant weeds have been reported. Glyphosate is mass-produced and widely used in China, but few studies and reports on glyphosate-resistant weeds and resistance mechanisms exist ...
Chun ZHANG, Li FENG, Ting-ting HE, Cai-hong YANG, Guo-qi CHEN, Xing-shan TIAN   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

eLife, 2020
Evolutionary innovations allow populations to colonize new ecological niches. We previously reported that aerobic growth on citrate (Cit+) evolved in an Escherichia coli population during adaptation to a minimal glucose medium containing citrate (DM25 ...
Zachary D Blount, Rohan Maddamsetti, Nkrumah A Grant, Sumaya T Ahmed, Tanush Jagdish, Jessica A Baxter, Brooke A Sommerfeld, Alice Tillman, Jeremy Moore, Joan L Slonczewski, Jeffrey E Barrick, Richard E Lenski   +11 more
doaj   +1 more source

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis

Oncogene, 2013
Disruption of the histone modification patterns is one of the most common features of human tumors. However, few genetic alterations in the histone modifier genes have been described in tumorigenesis.
Manuel Rodríguez-Paredes, Alexia Martínez de Paz, L. Simó-Riudalbas, Sergi, Sayols, Cátia Moutinho, S. Moran, A. Villanueva, -. MartaVázquez, Cedeira, P. Lazo, F. Carneiro, Conceiçao S. Moura, J. Vieira, M. Teixeira, M. Esteller   +15 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sexing From Seawater: Application of Environmental DNA Beyond Species Detection for Cetaceans

Environmental DNA
Anthropogenic pressures on marine ecosystems are intensifying, highlighting the need to bridge knowledge gaps for species at risk. Data deficiencies, particularly for species recovering from historic declines, such as marine megafauna like whales, hinder
Chloe Victoria Robinson, Emma June Laqua, Adam Warner, Gary J. Sutton, Michael W. D. Judson, Karina Dracott   +5 more
doaj   +1 more source