Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
International Journal of Oncology, 2013 Molecular targeted therapy is expected to be a promising therapeutic approach for the treatment of esophageal squamous cell carcinoma (ESCC); however, the gene amplification status of molecular targeted genes in ESCC remains largely unclear.
H. Kato +16 more
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Chromosomal destabilization during gene amplification. [PDF]
Molecular and Cellular Biology, 1990 Acentric extrachromosomal elements, such as submicroscopic autonomously replicating circular molecules (episomes) and double minute chromosomes, are common early, and in some cases initial, intermediates of gene amplification in many drug-resistant and tumor cell lines.
Geoffrey M. Wahl, Joseph C. Ruiz
openaire +3 more sources
Emerging Microbes and InfectionsWe identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had not been exposed CAZ/AVI.
Chao Liu +7 more
doaj +1 more source
Amplication of 0.7kb Fragment Katg Gene From Clinical Multi Drug Resistant Tuberculosis Isolate in Bali [PDF]
, 2013 During last decade has seen a particular increase in the occurrence of drug-resistant of tuberculosis (DR-TB) and multi-DR strains, such as Isoniazid (INH) resistant strains of M. tuberculosis. INH resistance is more frequently associated with mutations
Dwiputri, A. W. (A) +2 more
core
Multiplex quantitative PCR for single-reaction genetically modified (GM) plant detection and identification of false-positive GM plants linked to Cauliflower mosaic virus (CaMV) infection. [PDF]
, 2019 BACKGROUND:Most genetically modified (GM) plants contain a promoter, P35S, from the plant virus, Cauliflower mosaic virus (CaMV), and many have a terminator, TNOS, derived from the bacterium, Agrobacterium tumefaciens. Assays designed to detect GM plants
A Bak +35 more
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Single cell transcriptome analysis using next generation sequencing. [PDF]
, 2010 The heterogeneity of tissues, especially in cancer research, is a central issue in transcriptome analysis. In recent years, research has primarily focused on the development of methods for single cell analysis. Single cell analysis aims at gaining (novel)
Blattner, M.
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How to perform RT-qPCR accurately in plant species?: a case study on flower colour gene expression in an azalea (Rhododendron simsii hybrids) mapping population [PDF]
, 2013 Background: Flower colour variation is one of the most crucial selection criteria in the breeding of a flowering pot plant, as is also the case for azalea (Rhododendron simsii hybrids).
De Keyser, Ellen +3 more
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Neoplasia: An International Journal for Oncology Research, 2002 The development of genomic instability is an important step in generatingthe multiple genetic changes required for cancer. One consequence of genomic instability is the overexpression of oncogenes due to gene amplification.
Anthony W.l. Lo +5 more
doaj +1 more source
Demonstration of the Presence of the "Deleted" MIR122 Gene in HepG2 Cells [PDF]
, 2015 MicroRNA 122 (miR-122) is highly expressed in the liver where it influences diverse biological processes and pathways, including hepatitis C virus replication and metabolism of iron and cholesterol.
Fei, Y +8 more
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Identification of Genetic Elements Associated with EPSPS Gene Amplification
PLoS ONE, 2013 Weed populations can have high genetic plasticity and rapid responses to environmental selection pressures. For example, 100-fold amplification of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene evolved in the weed species Amaranthus palmeri
T. Gaines +8 more
semanticscholar +1 more source