Results 81 to 90 of about 8,013,600 (393)

Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.

Proceedings of the National Academy of Sciences of the United States of America, 1989
With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates ...
T. Kocher, W. Thomas, A. Meyer, S. Edwards, S. Pääbo, F. Villablanca, A. Wilson   +6 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Amplified biochemical oscillations in cellular systems

, 2006
We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations, fail to exhibit ...
A. Goldbeter, A. J. McKane, A. J. McKane, A. J. McKane, B. Alberts, B. Hess, B. Teusink, D. Bell-Pedersen, D. T. Gillespie, E. E. Sel’kov, E. Renshaw, G. Kurosawa, G. von Dassow, H. Goldstein, H. Li, J. B. Hansen, J. D. Nagy, M. Akashi, M. F. Madsen, M. Falcke, M. Falcke, M. Nakajima, M. O. Stefanini, M. S. Bartlett, N. G. Van Kampen, P. L. Lakin-Thomas, P. Smolen, R. M. Nisbet, T. J. Newman, U. Kummer, Z. Hou   +30 more
core   +1 more source

Reconstructing pedigrees using probabilistic analysis of ISSR amplification [PDF]

, 2015
Data obtained from ISSR amplification may readily be extracted but only allows us to know, for each gene, if a specific allele is present or not. From this partial information we provide a probabilistic method to reconstruct the pedigree corresponding to
Chaumont, Loïc, Malécot, Valéry, Pymar, Richard, Sbai, Chaker   +3 more
core   +3 more sources

Molecular Amplification and Cell Culturing Efficiency for Enteroviruses’ Detection in Cerebrospinal Fluids of Algerian Patients Suffering from Meningitis

Viruses
Enteroviruses (EVs) represent a major cause of viral meningitis, being responsible for nearly 1 billion infections each year worldwide. Several techniques were developed to obtain better diagnostic results of EV infections.
Abdelwahab Rai, Zohra Ammi, Dahbia Leila Anes-Boulahbal, Aymen Amin Assadi, Abdeltif Amrane, Oussama Baaloudj, Lotfi Mouni   +6 more
doaj   +1 more source

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis

Oncogene, 2013
Disruption of the histone modification patterns is one of the most common features of human tumors. However, few genetic alterations in the histone modifier genes have been described in tumorigenesis.
Manuel Rodríguez-Paredes, A. Paz, L. Simó-Riudalbas, Sergi Sayols, Cátia Moutinho, S. Moran, A. Villanueva, Marta Vázquez-Cedeira, P. Lazo, F. Carneiro, C. Moura, J. Vieira, M. Teixeira, M. Esteller   +13 more
semanticscholar   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, Volume 599, Issue 9, Page 1222-1235, May 2025.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma

International Journal of Oncology, 2013
Molecular targeted therapy is expected to be a promising therapeutic approach for the treatment of esophageal squamous cell carcinoma (ESCC); however, the gene amplification status of molecular targeted genes in ESCC remains largely unclear.
H. Kato, T. Arao, Kazuko Matsumoto, Y. Fujita, H. Kimura, H. Hayashi, K. Nishiki, Mitsuru Iwama, O. Shiraishi, A. Yasuda, M. Shinkai, M. Imano, H. Imamoto, T. Yasuda, K. Okuno, H. Shiozaki, K. Nishio   +16 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Gene Amplification in Bacillus subtilis [PDF]

Microbiology, 1984
A strain of Bacillus subtilis that carries in its genome a staphylococcal chloramphenicol acetyltransferase gene (from pC194) responds to growth at different concentrations of chloramphenicol by an alteration in the number of copies per genome of the sequences encoding the gene.
openaire   +3 more sources