Gene cassettes and cassette arrays in mobile resistance integrons [PDF]
FEMS Microbiology Reviews, 2009 Gene cassettes are small mobile elements, consisting of little more than a single gene and recombination site, which are captured by larger elements called integrons. Several cassettes may be inserted into the same integron forming a tandem array. The discovery of integrons in the chromosome of many species has led to the identification of thousands of
Sally R, Partridge +3 more
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Functional characterization of Tn1331 gene cassettes [PDF]
Journal of Antimicrobial Chemotherapy, 2008 The transposon Tn1331 possesses a region including three antibiotic resistance genes with the structure aac(6')-Ib-attC-aadA1-attI1*-bla(OXA-9)-attC, which potentially includes four gene cassettes. Experimental data on the mobility of fusion cassettes as well as those on mobility of cassettes in a genetic environment such as Tn1331, which lacks an ...
Maria S, Ramirez +3 more
openaire +3 more sources
Deletion of integron-associated gene cassettes impact on the surface properties of Vibrio rotiferianus DAT722. [PDF]
PLoS ONE, 2013 BackgroundThe integron is a genetic recombination system that catalyses the acquisition of genes on mobilisable elements called gene cassettes. In Vibrio species, multiple acquired gene cassettes form a cassette array that can comprise 1-3% of the ...
Rita A Rapa +4 more
doaj +4 more sources
The function of integron-associated genes cassettes in Vibrio species: the tip of the iceberg [PDF]
Frontiers in Microbiology, 2013 The integron is a genetic element that incorporates mobile genes termed gene cassettes into a reserved genetic site via site-specific recombination. It is best known for its role in antibiotic resistance with one type of integron, the class 1 integron, a
Rita A Rapa +3 more
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Site‐specific insertion of gene cassettes into integrons
Molecular Microbiology, 1993 SummarySite‐specific insertion of gene cassettes into the insert region of integrons has been demonstrated. Insertion was only observed if the integron DNA integrase was expressed in the recipient cell and if the cassette DNA was ligated prior to transformation.
C M, Collis +4 more
openaire +3 more sources
Context-driven discovery of gene cassettes in mobile integrons using a computational grammar [PDF]
BMC Bioinformatics, 2009 Background Gene discovery algorithms typically examine sequence data for low level patterns. A novel method to computationally discover higher order DNA structures is presented, using a context sensitive grammar.
Schaeffer Jaron +4 more
doaj +2 more sources
Integron gene cassettes: a repository of novel protein folds with distinct interaction sites. [PDF]
PLoS ONE, 2013 Mobile gene cassettes captured within integron arrays encompass a vast and diverse pool of genetic novelty. In most cases, functional annotation of gene cassettes directly recovered by cassette-PCR is obscured by their characteristically high sequence ...
Visaahini Sureshan +8 more
doaj +3 more sources
Mobile Gene Cassettes: A Fundamental Resource for Bacterial Evolution
The American Naturalist, 2004 Horizontal gene transfer increases genetic diversity in prokaryotes to a degree not allowed by the limitations of reproduction by binary fission. The integron/gene cassette system is one of the most recently characterized examples of a system that facilitates horizontal gene transfer.
Carolyn A, Michael +6 more
core +4 more sources
Methods for the targeted sequencing and analysis of integrons and their gene cassettes from complex microbial communities. [PDF]
Microb Genom, 2022 Integrons are microbial genetic elements that can integrate mobile gene cassettes. They are mostly known for spreading antibiotic resistance cassettes among human pathogens.
Ghaly TM +6 more
europepmc +2 more sources
Gene cassette transcription in a large integron-associated array [PDF]
BMC Genetics, 2010 Background The integron/gene cassette system is a diverse and effective adaptive resource for prokaryotes. Short cassette arrays, with less than 10 cassettes adjacent to an integron, provide this resource through the expression of cassette-associated ...
Michael Carolyn A, Labbate Maurizio
doaj +3 more sources