Results 41 to 50 of about 54,378 (282)

Identification and characterization of integron-mediated antibiotic resistance in the phytopathogen Xanthomonas oryzae pv. oryzae. [PDF]

PLoS ONE, 2013
Four streptomycin-resistant isolates of Xanthomonas oryzae pv. oryzae (YNA7-1, YNA10-2, YNA11-2, and YNA12-2) were examined via PCR amplification for the presence of class 1, class 2, and class 3 integrons and aadA1 and aadA2 genes, which confer ...
Ying Xu, Qing-quan Luo, Ming-guo Zhou
doaj   +1 more source

First Gene Cassettes of Integrons as Targets in Finding Adaptive Genes in Metagenomes [PDF]

Applied and Environmental Microbiology, 2009
ABSTRACT The first gene cassettes of integrons are involved in the last adaptation response to changing conditions and are also the most expressed. We propose a rapid method for the selection of clones carrying an integron first gene cassette that is useful for finding adaptive genes in environmental metagenomic libraries.
Lionel, Huang, Christine, Cagnon, Pierre, Caumette, Robert, Duran   +3 more
openaire   +2 more sources

Characterization Integrons and Gene Cassettes in Trimethoprim/Sulfamethoxazole-resistant Stenotrophomonas maltophilia

Journal of Medical Sciences
Background: Integrons in Stenotrophomonas maltophilia are the major mechanism for trimethoprim/sulfamethoxazole (TMP/SMX) resistance. Molecular epidemiology of S.
Jiun-Ji Lai, Yi-Ping Chuang, Rui-Xin Wu, Ching-Mei Yu, Hung-Sheng Shang, Ching-Hsun Wang   +5 more
doaj   +1 more source

Dual gene expression cassette is superior than single gene cassette for enhancing sheath blight tolerance in transgenic rice [PDF]

Scientific Reports, 2017
AbstractSheath blight, caused by the necrotrophic fungal pathogen Rhizoctonia solani, is a serious and destructive disease of the rice. In order to improve sheath blight resistance, we developed three different kinds of transgenic rice lines. The first transgenic line overexpresses the rice chitinase gene (OsCHI11); the second contains the Arabidopsis ...
Subhasis Karmakar, Kutubuddin A. Molla, Kaushik Das, Sailendra Nath Sarkar, Swapan K. Datta, Karabi Datta   +5 more
openaire   +3 more sources

Emergence of the mcr-1 colistin resistance gene in extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Taiwan

Journal of Global Antimicrobial Resistance, 2021
Objectives: The resistance ofmcr-1-carrying Enterobacteriaceae to polymyxins, which are last-resort antibiotics, has raised great concern worldwide. In this study, four mcr-1-carrying plasmids isolated from Klebsiella pneumoniae clinical isolates were ...
Yu-Chi Lin, Makoto Kuroda, Satowa Suzuki, Jung-Jung Mu   +3 more
doaj   +1 more source

Characterization of the novel In1059 harbouring VIM gene cassette [PDF]

Antimicrobial Resistance & Infection Control, 2017
VIM-type enzyme encodes the most widely acquired metallo-β-lactamases in Gram- negative bacteria. To obtain current epidemiological data for integrons from enterobacteriae in hospital, the study characterizes the genetic structure in In1059 by comparison with In846 integrons harbouring VIM gene and other class 1 integrons including In37, In62, In843 ...
Dongguo Wang, Jinhong Yang, Meiyu Fang, Wei He, Ying Zhang, Caixia Liu, Dongsheng Zhou   +6 more
openaire   +3 more sources

Phylogenetic Profiler for Gene Cassettes.

, 2013
Phylogenetic Profiler for Gene Cassettes.
Nikos C. Kyrpides (13837), Konstantinos Mavromatis (13836), Natalia Ivanova (8850), Sean D. Hooper (5540), Ken Chu (283940), Victor M. Markowitz (13826)   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Inverse correlation between promoter strength and excision activity in class 1 integrons. [PDF]

PLoS Genetics, 2010
Class 1 integrons are widespread genetic elements that allow bacteria to capture and express gene cassettes that are usually promoterless. These integrons play a major role in the dissemination of antibiotic resistance among Gram-negative bacteria.
Thomas Jové, Sandra Da Re, François Denis, Didier Mazel, Marie-Cécile Ploy   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source