Results 61 to 70 of about 95,867 (295)

Characterization of the resistance class 1 integrons in Staphylococcus aureus isolates from milk of lactating dairy cattle in Northwestern China

BMC Veterinary Research, 2018
Background Integrons are mobile DNA elements and they have an important role in acquisition and dissemination of antimicrobial resistance genes. However, there are limited data available on integrons of Staphylococcus aureus (S.
Longping Li, Xin Zhao
doaj   +1 more source

Detection of VIM-1-producing Enterobacter cloacae and Salmonella enterica Serovars Infantis and Goldcoast at a breeding pig farm in Germany in 2017 and their molecular relationship to former VIM-1-producing S. Infantis Isolates in German livestock production [PDF]

, 2019
In 2011, VIM-1-producing Salmonella enterica serovar Infantis and Escherichia coli were isolated for the first time in four German livestock farms. In 2015/2016, highly related isolates were identified in German pig production.
Borowiak, Maria, Guenther, Sebastian, Hadziabdic, Sead, Kaesbohrer, Annemarie, Malorny, Burkhard, Projahn, Michaela, Roesler, Uwe [u.v.m.], Roschanski, Nicole, Szabo, Istvan, Tenhagen, Bernd-Alois   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Gidijala, Loknath,, Kiel, Jan A.K.W.,, Klei, Ida J. van der,, Veenhuis, Marten,   +3 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of Citrobacter spp. with multidrug resistance

Iranian Journal of Microbiology, 2018
Background and Objectives: Integrons play a major role in the transmission and accumulation of resistance factors in multidrug resistant bacteria. This study was aimed to evaluate the gene cassettes of class I integron and antimicrobial resistance in ...
Roya Chegene Lorestani, Alisha Akya, Azam Elahi, Yazdan Hamzavi   +3 more
doaj  

Occurrence Of Class 1 And 2 Integrons In Enterobacteriaceae Collected From Zagazig University Hospitals, Egypt

Frontiers in Microbiology, 2015
Integrons are genetic units characterized by ability to capture and incorporate gene cassettes that can contribute to emergence and transfer of antibiotic resistance between bacteria.
Mai eMalek, Fatma Abdelaziz Amer, Ayman eAllam, Rehab eEl-Sokkary, Tarek eGheith, Mohamed eArafa   +5 more
doaj   +1 more source

Parvovirus-derived endogenous viral elements in two South American rodent genomes [PDF]

, 2014
We describe endogenous viral elements (EVEs) derived from parvoviruses (family <i>Parvoviridae</i>) in the long-tailed chinchilla (<i>Chinchilla lanigera</i>) and degu (<i>Octodon degus</i>) genomes.
Abascal, Antoine, Ardiles, Arnaud, Belyi, Bezier, Dewannieux, G. Arriagada, Gould, Guindon, Kapoor, Katzourakis, Kumar, Liu, Naccache, Okanoya, Opazo, Phan, R. J. Gifford, Rowe, Smuts   +20 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Molecular study of metallo-β-lactamases and integrons in Acinetobacter baumannii isolates from burn patients

BMC Infectious Diseases, 2021
Background Productions of metallo-β-lactamases enzymes are the most common mechanism of antibiotic resistance to all beta-lactam classes (except monobactams) in Acinetobacter baumannii.
Mahnaz Nikibakhsh, Farzaneh Firoozeh, Farzad Badmasti, Kourosh Kabir, Mohammad Zibaei   +4 more
doaj   +1 more source