Results 21 to 30 of about 3,120,234 (211)
EPISOMAL EXPRESSION CASSETTES FOR GENE THERAPY [PDF]
, 1998 The invention consists of episomal expression cassettes for expression of a tran sgene in gene therapy. The expression cassettes consist of regulatory elements of the human cytokeratin gene and a transgene.
core +2 more sources
Dynamics of class 1 integrons in aerobic biofilm reactors spiked with antibiotics
Environment International, 2020 Class 1 integrons are strongly associated with the dissemination of antibiotic resistance in bacteria. However, little is known about whether the presence of antibiotics affects the abundance of integrons and antibiotic resistance genes during biological
Jiaoqi Huyan +6 more
doaj +1 more source
Phylogenetic Profiler for Gene Cassettes.
, 2013 Phylogenetic Profiler for Gene Cassettes.
Nikos C. Kyrpides (13837) +5 more
core +1 more source
Identification and characterization of integron-mediated antibiotic resistance in the phytopathogen Xanthomonas oryzae pv. oryzae. [PDF]
PLoS ONE, 2013 Four streptomycin-resistant isolates of Xanthomonas oryzae pv. oryzae (YNA7-1, YNA10-2, YNA11-2, and YNA12-2) were examined via PCR amplification for the presence of class 1, class 2, and class 3 integrons and aadA1 and aadA2 genes, which confer ...
Ying Xu, Qing-quan Luo, Ming-guo Zhou
doaj +1 more source
Journal of Medical SciencesBackground: Integrons in Stenotrophomonas maltophilia are the major mechanism for trimethoprim/sulfamethoxazole (TMP/SMX) resistance. Molecular epidemiology of S.
Jiun-Ji Lai +5 more
doaj +1 more source
Integron gene cassettes: a repository of novel protein folds with distinct interaction sites. [PDF]
PLoS ONE, 2013 Mobile gene cassettes captured within integron arrays encompass a vast and diverse pool of genetic novelty. In most cases, functional annotation of gene cassettes directly recovered by cassette-PCR is obscured by their characteristically high sequence ...
Visaahini Sureshan +8 more
doaj +1 more source
Inverse correlation between promoter strength and excision activity in class 1 integrons. [PDF]
PLoS Genetics, 2010 Class 1 integrons are widespread genetic elements that allow bacteria to capture and express gene cassettes that are usually promoterless. These integrons play a major role in the dissemination of antibiotic resistance among Gram-negative bacteria.
Thomas Jové +4 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Journal of Global Antimicrobial Resistance, 2021 Objectives: The resistance ofmcr-1-carrying Enterobacteriaceae to polymyxins, which are last-resort antibiotics, has raised great concern worldwide. In this study, four mcr-1-carrying plasmids isolated from Klebsiella pneumoniae clinical isolates were ...
Yu-Chi Lin +3 more
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source