Results 201 to 210 of about 7,614,096 (384)

A Post-transcriptional Compensatory Pathway in Heterozygous Ventricular Myosin Light Chain 2-Deficient Mice Results in Lack of Gene Dosage Effect during Normal Cardiac Growth or Hypertrophy [PDF]

, 1999
Susumu Minamisawa, Yusu Gu, John Ross, Kenneth R. Chien, Ju Chen   +4 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes. [PDF]

JCI Insight, 2023
Horani A, Gupta DK, Xu J, Xu H, Carmen Puga-Molina LD, Santi CM, Ramagiri S, Brennan SK, Pan J, Koenitzer JR, Huang T, Hyland RM, Gunsten SP, Tzeng SC, Strahle JM, Mill P, Mahjoub MR, Dutcher SK, Brody SL.   +18 more
europepmc   +1 more source

Replication‐associated gene dosage effects shape the genomes of fast‐growing bacteria but only for transcription and translation genes [PDF]

, 2006
Étienne Couturier, Eduardo P. C. Rocha
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration [PDF]

, 2023
Anne Skakkebæk, Kasper Kjær-Sørensen, Vladimir V. Matchkov, Lise-Lotte Christensen, Jesper Just, Cagla Cömert, N.H. Andersen, Claus Oxvig, Claus Højbjerg Gravholt   +8 more
openalex   +1 more source

Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry

Journal of Neuroscience, 2016
A. Lin, C. Ching, A. Vajdi, Daqiang Sun, R. Jonas, M. Jalbrzikowski, Leila Kushan-Wells, Laura Pacheco Hansen, Emma Krikorian, B. Gutman, Deepika Dokoru, G. Helleman, P. Thompson, C. Bearden   +13 more
semanticscholar   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis. [PDF]

iScience, 2023
Ta L, Tsai BL, Deng W, Sha J, Varuzhanyan G, Tran W, Wohlschlegel JA, Carr-Ascher JR, Witte ON.   +8 more
europepmc   +1 more source