Results 51 to 60 of about 7,614,096 (384)
Rambam Maimonides Medical Journal, 2011 Genetic determinants of sex in placental mammals developed by the evolution of primordial autosomes into the male and female sex chromosomes. The Y chromosome determines maleness by the action of the gene SRY, which encodes a protein that initiates a ...
Sophia Balderman, Marshall A. Lichtman
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Accelerating pathway evolution by increasing the gene dosage of chromosomal segments
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Gene duplication and divergence are cornerstones of evolution. Genetic redundancy resulting from repeated DNA provides flexibility for transient changes in copy number that may confer selective benefit under new or changing environmental ...
Melissa P. Tumen-Velasquez +11 more
semanticscholar +1 more source
Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]
, 2015 The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R +4 more
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Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont
mSystems, 2017 Secondary metabolites, which are small-molecule organic compounds produced by living organisms, provide or inspire drugs for many different diseases.
J. Lopera +3 more
semanticscholar +1 more source
Gene dosage effects of poly(A) track-engineered hypomorphs
Molecular Therapy: Nucleic Acids, 2021 Manipulation of gene activity through creation of hypomorphic mutants has been a long-standing tool in examining gene function. Our previous studies have indicated that hypomorphic mutants could be created by inserting cis-regulatory sequences composed ...
Geralle Powell +2 more
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Abnormal Action Potentials Associated with the Shaker Complex Locus of Drosophila [PDF]
, 1981 Intracellular recordings of action potentials were made from the cervical giant axon in Shaker (Sh) mutants and normal Drosophila. The mutants showed abnormally long delays in repolarization.
Ferrus, Alberto +2 more
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A general lack of compensation for gene dosage in yeast
Molecular Systems Biology, 2010 Gene copy number variation has been discovered in humans, between related species, and in different cancer tissues, but it is unclear how much of this genomic‐level variation leads to changes in the level of protein abundance.
Michael Springer +2 more
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CNV and nervous system diseases - what's new? [PDF]
, 2008 Several new genomic disorders caused by copy number variation (CNV) of genes whose dosage is critical for the physiological function of the nervous system have been recently identified.
Gu, W., Lupski, J. R.
core +3 more sources
FOXG1 Dose in Brain Development
Frontiers in Pediatrics, 2019 Brain development is a highly regulated process that involves the precise spatio-temporal activation of cell signaling cues. Transcription factors play an integral role in this process by relaying information from external signaling cues to the genome ...
Nuwan C. Hettige +5 more
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Clinical features and genetic characteristics of homozygous spinocerebellar ataxia type 3
Molecular Genetics & Genomic Medicine, 2020 Background Homozygous spinocerebellar ataxia type 3 (SCA3) patients, which have an expanded cytosine‐adenine‐guanine (CAG) repeat mutation in both alleles of ATXN3, are extremely rare.
Quan-Fu Li +6 more
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