Results 51 to 60 of about 7,162,706 (382)
Paralog dependency indirectly affects the robustness of human cells
Molecular Systems Biology, 2019 The protective redundancy of paralogous genes partly relies on the fact that they carry their functions independently. However, a significant fraction of paralogous proteins may form functionally dependent pairs, for instance, through heteromerization ...
Rohan Dandage, Christian R Landry
doaj +1 more source
A General Mechanism for Network-Dosage Compensation in Gene Circuits [PDF]
, 2010 Coping with variations in network dosage is crucial for maintaining optimal function in gene networks. We explored how network structure facilitates network-level dosage compensation.
Acar, Murat +4 more
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Dosage-sensitivity of human transcription factor genes [PDF]
Frontiers in Genetics, 2019 AbstractChanges in the copy number of protein-coding genes would lead to detrimental effects if the consequent changes in protein concentration disrupt essential cellular functions. Large-scale genomic studies have identified thousands of dosage-sensitive genes in human genome.
Deng-Ke Niu +4 more
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Growth-rate-dependent dynamics of a bacterial genetic oscillator [PDF]
, 2013 Gene networks exhibiting oscillatory dynamics are widespread in biology. The minimal regulatory designs giving rise to oscillations have been implemented synthetically and studied by mathematical modeling.
Lagomarsino, Marco Cosentino +1 more
core +3 more sources
The evolution of gene duplicates in angiosperms and the impact of protein-protein interactions and the mechanism of duplication [PDF]
, 2019 Gene duplicates, generated through either whole genome duplication (WGD) or small-scale duplication (SSD), are prominent in angiosperms and are believed to play an important role in adaptation and in generating evolutionary novelty.
Carretero-Paulet, Lorenzo +2 more
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Expression of muscle genes in heterokaryons depends on gene dosage. [PDF]
The Journal of cell biology, 1986 We report that gene dosage, or the ratio of nuclei from two cell types fused to form a heterokaryon, affects the time course of differentiation-specific gene expression. The rate of appearance of the human muscle antigen, 5.1H11, is significantly faster in heterokaryons with equal or near-equal numbers of mouse muscle and human fibroblast nuclei than ...
Helen M. Blau, Grace K. Pavlath
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Rare dosage abnormalities flanking the SHOX gene
Egyptian Journal of Medical Human Genetics, 2021 Background Transcriptional regulation of the SHOX gene is highly complex. Much of our understanding has come from the study of copy number changes of conserved non-coding sequences both upstream and downstream of the gene.
David J. Bunyan +14 more
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Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]
, 2019 Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris +2 more
core +1 more source
mBio, 2017 Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz +17 more
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Clinical features and genetic characteristics of homozygous spinocerebellar ataxia type 3
Molecular Genetics & Genomic Medicine, 2020 Background Homozygous spinocerebellar ataxia type 3 (SCA3) patients, which have an expanded cytosine‐adenine‐guanine (CAG) repeat mutation in both alleles of ATXN3, are extremely rare.
Quan-Fu Li +6 more
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