Results 71 to 80 of about 7,614,096 (384)

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Characterization and Comparison of 2 Distinct Epidemic Community-Associated Methicillin-Resistant Staphylococcus aureus Clones of ST59 Lineage. [PDF]

, 2013
Sequence type (ST) 59 is an epidemic lineage of community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) isolates. Taiwanese CA-MRSA isolates belong to ST59 and can be grouped into 2 distinct clones, a virulent Taiwan clone and a ...
A Bera, A Holmes, AE Fossum, AM Milstone, B Loffler, BA Diep, BE Gonzalez, BE Gonzalez, C Goerke, C Weidenmaier, Chih-Jung Chen, CJ Chen, CJ Chen, CJ Chen, CJ Chen, CJC de Haas, Clemens Unger, CP Montgomery, dS Aires, FC Tenover, FJ Chen, Friedrich Götz, GM Pupo, GW Coombs, J Bubeck Wardenburg, J Bubeck Wardenburg, J Kaneko, JM Voyich, Jodi A. Lindsay, K Georgiades, KB Kiser, LY Hsu, M Labandeira-Rey, M Otto, MR Mulvey, MZ David, N Zetola, Paul J. Planet, PE Fournier, PL Ho, R Wang, S Herbert, SHM Rooijakkers, SL Kaplan, T Jin, T Jin, V Merhej, WJ Wannet, WJB van Wamel, Wolfgang Hoffmann, Y Gillet, YC Huang, YC Huang, YC Huang, YC Huang, Yhu-Chering Huang   +55 more
core   +3 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

DYRK1A in the physiology and pathology of the neuron-astrocyte axis

Frontiers in Neuroscience
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dosage-sensitive kinase with critical roles in the neuron-astrocyte axis. During brain development, DYRK1A ensures the proper number of differentiated neurons and astrocytes.
Pablo Cisternas, Pablo Cisternas, Jiyoon Kim, Brandon Ashfeld, Jeremiah Zartman, Jeremiah Zartman   +5 more
doaj   +1 more source

Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants [PDF]

, 2016
Background: the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases.
Anderson, Jana, Bailey, Mark E.S., Celis, Carlos, Cullen, Breda, Davies, Gail, Deary, Ian J., Evans, Jon, Lyall, Donald M., Mackay, Daniel, McIntosh, Andrew M., Pell, Jill P., Ritchie, Stuart J., Sattar, Naveed, Smith, Daniel J., Ward, Joey   +14 more
core   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Multiple strategies were adopted to optimize the enzymatic characteristics and improve the expression of bovine chymosin BtChy in Kluyveromyces lactis for cheese production

Frontiers in Microbiology
Chymosin (EC3.4.23.4), primarily sourced from calf abomasum, serves as a conventional coagulant in milk curdling during cheese production. To improve the enzymatic properties and enhance the expression of calf chymosin (BtChy) in Kluyveromyces lactis to ...
Ying Han, Liu-Qun Zhang, De-Ming Rao, Lei Lei, Jiang-Ke Yang   +4 more
doaj   +1 more source

Single-molecule long-read sequencing reveals the potential impact of posttranscriptional regulation on gene dosage effects on the avian Z chromosome

BMC Genomics, 2022
Background Mammalian sex chromosomes provide dosage compensation, but avian lack a global mechanism of dose compensation. Herein, we employed nanopore sequencing to investigate the genetic basis of gene expression and gene dosage effects in avian Z ...
Jianmei Wang, Yang Xi, Shengchao Ma, Jingjing Qi, Junpeng Li, Rongping Zhang, Chunchun Han, Liang Li, Jiwen Wang, Hehe Liu   +9 more
doaj   +1 more source

Incomplete sex chromosome dosage compensation in the Indian meal moth, Plodia interpunctella, based on de novo transcriptome assembly. [PDF]

, 2016
Journal ArticleResearch Support, Non-U.S. Gov'tMales and females experience differences in gene dose for loci in the nonrecombining region of heteromorphic sex chromosomes. If not compensated, this leads to expression imbalances, with the homogametic sex
Harrison, PW, Mank, JE, Wedell, Nina
core   +1 more source

The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity

PLoS Genetics, 2015
Noncoding sequence contains pathogenic mutations. Yet, compared with mutations in protein-coding sequence, pathogenic regulatory mutations are notoriously difficult to recognize.
S. Petrovski, Ayal B. Gussow, Quanli Wang, M. Halvorsen, Yujun Han, W. Weir, A. Allen, D. Goldstein   +7 more
semanticscholar   +1 more source