The roles of segmental and tandem gene duplication in the evolution of large gene families in
BMC Plant Biology, 2004 Background Most genes in Arabidopsis thaliana are members of gene families. How do the members of gene families arise, and how are gene family copy numbers maintained?
Baumgarten Andrew +4 more
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Can Introns Stabilize Gene Duplication? [PDF]
Biology, 2022 Gene duplication is considered one of the most important events that determine the evolution of genomes. However, the neo-duplication condition of a given gene is particularly unstable due to recombination events. Several mechanisms have been proposed to
Gioacchino Micheli, Giorgio Camilloni
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A probabilistic model for gene content evolution with duplication, loss, and horizontal transfer [PDF]
, 2005 We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gene loss, in addition to branch lengths in the phylogeny. The likelihood for the changes in the size of a gene family across different organisms can be calculated in O(N+hM^2 ...
A.B. Simonson +43 more
arxiv +4 more sources
Maximum likelihood models and algorithms for gene tree evolution with duplications and losses [PDF]
BMC Bioinformatics, 2011 Background The abundance of new genomic data provides the opportunity to map the location of gene duplication and loss events on a species phylogeny. The first methods for mapping gene duplications and losses were based on a parsimony criterion, finding ...
Burleigh Gordon J +2 more
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Phylogenomics: gene duplication, unrecognized paralogy and outgroup choice. [PDF]
PLoS ONE, 2009 Comparative genomics has revealed the ubiquity of gene and genome duplication and subsequent gene loss. In the case of gene duplication and subsequent loss, gene trees can differ from species trees, thus frequent gene duplication poses a challenge for ...
Scott William Roy
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Acquisition of new function through gene duplication in the metallocarboxypeptidase family [PDF]
Scientific Reports, 2023 Gene duplication is a key first step in the process of expanding the functionality of a multigene family. In order to better understand the process of gene duplication and its role in the formation of new enzymes, we investigated recent duplication ...
Daniel Fajardo +2 more
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Counting Subnetworks Under Gene Duplication in Genetic Regulatory Networks [PDF]
arXivGene duplication is a fundamental evolutionary mechanism that contributes to biological complexity and diversity (Fortna et al., 2004). Traditionally, research has focused on the duplication of gene sequences (Zhang, 1914). However, evidence suggests that the duplication of regulatory elements may also play a significant role in the evolution of ...
Arnold, Jonathan +2 more
arxiv +2 more sources
Gene & Genome Duplication in Acanthamoeba Polyphaga Mimivirus [PDF]
arXiv, 2005 Gene duplication is key to molecular evolution in all three domains of life and may be the first step in the emergence of new gene function. It is a well recognized feature in large DNA viruses, but has not been studied extensively in the largest known virus to date, the recently discovered Acanthamoeba Polyphaga Mimivirus. Here we present a systematic
Suhre, Karsten
arxiv +3 more sources
Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication [PDF]
Frontiers in ImmunologyMutations in the complement factor H (CFH) gene are associated with complement dysregulation and the development of atypical hemolytic uremic syndrome (aHUS).
Yuko Tasaki +10 more
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BMC Bioinformatics, 2022 Background Research on gene duplication is abundant and comes from a wide range of approaches, from high-throughput analyses and experimental evolution to bioinformatics and theoretical models.
Yuridia S. Posadas-García +1 more
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