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The roles of segmental and tandem gene duplication in the evolution of large gene families in
BMC Plant Biology, 2004 Background Most genes in Arabidopsis thaliana are members of gene families. How do the members of gene families arise, and how are gene family copy numbers maintained?
Baumgarten Andrew +4 more
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On the origins of Mendelian disease genes in man: the impact of gene duplication [PDF]
, 2011 Over 3,000 human diseases are known to be linked to heritable genetic variation, mapping to over 1,700 unique genes. Dating of the evolutionary age of these disease-associated genes has suggested that they have a tendency to be ancient, specifically ...
Dickerson, Jonathan E. +1 more
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An ILP solution for the gene duplication problem [PDF]
BMC Bioinformatics, 2011 Background The gene duplication (GD) problem seeks a species tree that implies the fewest gene duplication events across a given collection of gene trees.
Fernández-Baca David F +3 more
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Gene duplication and deletion caused by over-replication at a fork barrier. [PDF]
Nat Commun, 2023 Oehler J, Morrow CA, Whitby MC.
europepmc +2 more sources
BMC Bioinformatics, 2022 Background Research on gene duplication is abundant and comes from a wide range of approaches, from high-throughput analyses and experimental evolution to bioinformatics and theoretical models.
Yuridia S. Posadas-García +1 more
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Gene Complexity and Gene Duplicability [PDF]
Current Biology, 2005 Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higher rate of gene duplication than prokaryotes do [6, 7]. Because gene duplication is the primary source of new genes [], the average gene complexity in a genome
He, Xionglei, Zhang, Jianzhi
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Gene Dosage and Gene Duplicability [PDF]
Genetics, 2008 Abstract The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more ...
Wenfeng, Qian, Jianzhi, Zhang
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BMC Genomics, 2023 Background In the evolutionary study of gene families, exploring the duplication mechanisms of gene families helps researchers understand their evolutionary history.
Huilong Chen +2 more
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Frontiers in Cell and Developmental Biology, 2022 The process of gene duplication followed by gene loss or evolution of new functions has been studied extensively, yet the role gene duplication plays in the function and evolution of fertilization proteins is underappreciated.
Alberto M. Rivera, Willie J. Swanson
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Patterns of gene evolution following duplications and speciations in vertebrates [PDF]
PeerJ, 2020 Background Eukaryotic genes typically form independent evolutionary lineages through either speciation or gene duplication events. Generally, gene copies resulting from speciation events (orthologs) are expected to maintain similarity over time with ...
Kyle T. David +2 more
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