Results 51 to 60 of about 7,215,457 (388)
Has gene duplication impacted the evolution of Eutherian longevity? [PDF]
, 2016 One of the greatest unresolved questions in aging biology is determining the genetic basis of interspecies longevity variation. Gene duplication is often the key to understanding the origin and evolution of important Eutherian phenotypes.
de Magalhaes, Joao Pedro, Doherty, Aoife
core +1 more source
The Evolutionary Relationship between Alternative Splicing and Gene Duplication
Frontiers in Genetics, 2017 The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of ...
Luis P. Iñiguez, G. Hernández
semanticscholar +1 more source
Selection in the evolution of gene duplications [PDF]
Genome Biology, 2002 Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolution of a new function.In search of systematic
Fyodor A, Kondrashov +3 more
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A novel evolutionary model for constructing gene coexpression networks with comprehensive features
BMC Bioinformatics, 2019 Background Uncovering the evolutionary principles of gene coexpression network is important for our understanding of the network topological property of new genes.
Yuexi Gu, Jian Zu, Yu Li
doaj +1 more source
Gene Duplication and Protein Evolution in Tick-Host Interactions
Frontiers in Cellular and Infection Microbiology, 2017 Ticks modulate their hosts' defense responses by secreting a biopharmacopiea of hundreds to thousands of proteins and bioactive chemicals into the feeding site (tick-host interface).
B. Mans +3 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2017 Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of innovations .
Florian Mattenberger +3 more
doaj +1 more source
Plant Direct, 2020 Polyploidization, or whole‐genome duplication, leads to gene expression changes that drive the evolution of many plants and some animals. However, the role of the dosage effect on gene expression changes following genome duplication remains unclear. Here,
Shouli Feng +6 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Frontiers in Genetics, 2021 The annular pancreas (AP) is a congenital anomaly of the pancreas that can cause acute abdominal pain and vomiting after birth. However, the genetic cause of AP is still unknown, and no study has reported AP in patients with 17q12 duplication. This study
Feifan Xiao +23 more
doaj +1 more source
Hierarchy and Feedback in the Evolution of the E. coli Transcription Network [PDF]
, 2007 The E.coli transcription network has an essentially feedforward structure, with, however, abundant feedback at the level of self-regulations. Here, we investigate how these properties emerged during evolution.
Atkinson +28 more
core +2 more sources