Results 51 to 60 of about 318,177 (248)

Overdosage of HNF1B Gene Associated With Annular Pancreas Detected in Neonate Patients With 17q12 Duplication

Frontiers in Genetics, 2021
The annular pancreas (AP) is a congenital anomaly of the pancreas that can cause acute abdominal pain and vomiting after birth. However, the genetic cause of AP is still unknown, and no study has reported AP in patients with 17q12 duplication. This study
Feifan Xiao, Feifan Xiao, Xiuyun Liu, Xiuyun Liu, Yulan Lu, Bingbing Wu, Renchao Liu, Bo Liu, Kai Yan, Huiyao Chen, Huiyao Chen, Guoqiang Cheng, Laishuan Wang, Qi Ni, Qi Ni, Gang Li, Ping Zhang, Xiaomin Peng, Yun Cao, Chun Shen, Huijun Wang, Wenhao Zhou, Wenhao Zhou, Wenhao Zhou   +23 more
doaj   +1 more source

On Gene Duplication Models for Evolving Regulatory Networks [PDF]

, 2007
Background: Duplication of genes is important for evolution of molecular networks. Many authors have therefore considered gene duplication as a driving force in shaping the topology of molecular networks. In particular it has been noted that growth via duplication would act as an implicit way of preferential attachment, and thereby provide the observed
arxiv   +1 more source

Gene duplication, population genomics, and species-level differentiation within a tropical mountain shrub. [PDF]

, 2014
Gene duplication leads to paralogy, which complicates the de novo assembly of genotyping-by-sequencing (GBS) data. The issue of paralogous genes is exacerbated in plants, because they are particularly prone to gene duplication events.
Alvarez, N., Arrigo, N., Emerson, B.C., Jorgensen, T.H., Mastretta-Yanes, A., Piñero, D., Zamudio, S.   +6 more
core   +2 more sources

The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations

G3: Genes, Genomes, Genetics, 2017
Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of innovations .
Florian Mattenberger, Beatriz Sabater-Muñoz, Christina Toft, Mario A. Fares   +3 more
doaj   +1 more source

Chromosome duplication causing gene‐dosage‐based effects on the gene expression level in Gossypium hirsutum‐Gossypium australe addition lines

Plant Direct, 2020
Polyploidization, or whole‐genome duplication, leads to gene expression changes that drive the evolution of many plants and some animals. However, the role of the dosage effect on gene expression changes following genome duplication remains unclear. Here,
Shouli Feng, Min Xu, Haiyue Guo, Fujie Liu, Changjiang Cui, Ting Zhao, Baoliang Zhou   +6 more
doaj   +1 more source

Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene [PDF]

BMC Molecular Biology 2007, 8:109, 2008
Background: Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes.
arxiv   +1 more source

Revealing mammalian evolutionary relationships by comparative analysis of gene clusters [PDF]

, 2012
Many software tools for comparative analysis of genomic sequence data have been released in recent decades. Despite this, it remains challenging to determine evolutionary relationships in gene clusters due to their complex histories involving ...
Abi-Rached, Akahoshi, Bailey, Benjamin Dickins, Birney, Cadavid, Cathy Riemer, Chen, Chih-Hao Hsu, Chiu, Colobran, Datta, Degenhardt, Dewey, Dufayard, Edwards, Eric D. Green, Fitch, Fitch, Fitch, Giltae Song, Gish, Gonzalez, Goodstadt, Graef, Guethlein, Guethlein, Han, Hardies, Hardison, Hardison, Hardison, Harris, Hie Lim Kim, Hoffmann, Hou, Hou, Hsu, Hsu, Hu, Huerta-Cepas, Jensen, Johnson, Kim, Kristensen, Lee, Levy, Li, Li, Lopez-Vazquez, Louxin Zhang, Margulies, Martin, Matsuya, Mi, Miyata, Muller, Murphy, NISC Comparative Sequencing Program, , Opazo, Opazo, Ostlund, Ouzounis, Parham, Pianezza, Rajalingam, Ross C. Hardison, Sambrook, Shilling, Siepel, Smit, Song, Song, Song, Sonnhammer, Su, Tatusov, The ENCODE Project Consortium, Uchiyama, van der Heijden, Vilella, Wang, Wapinski, Waterhouse, Webb Miller, Wilson, Wilson, Woelk, Yu Zhang, Zhang   +89 more
core   +2 more sources

The evolution of gene duplicates in angiosperms and the impact of protein-protein interactions and the mechanism of duplication [PDF]

, 2019
Gene duplicates, generated through either whole genome duplication (WGD) or small-scale duplication (SSD), are prominent in angiosperms and are believed to play an important role in adaptation and in generating evolutionary novelty.
Carretero-Paulet, Lorenzo, Defoort, Jonas, Van de Peer, Yves   +2 more
core   +2 more sources

Duplicated genes evolve slower than singletons despite the initial rate increase

BMC Evolutionary Biology, 2004
Background Gene duplication is an important mechanism that can lead to the emergence of new functions during evolution. The impact of duplication on the mode of gene evolution has been the subject of several theoretical and empirical comparative-genomic ...
Koonin Eugene V, Wolf Yuri I, Jordan I King   +2 more
doaj   +1 more source

Model of haplotype and phenotype in the evolution of a duplicated autoregulatory activator [PDF]

Journal of Theoretical Biology 325 (2013), 2012
Gene duplication is believed to play a major role in the evolution of genomic complexity. The presence of a duplicate removes the constraint of natural selection upon the gene, leading to its likely loss of function or, occasionally, the gain of a novel one.
arxiv   +1 more source