Results 11 to 20 of about 7,473,287 (361)
Application of CRISPR/Cas9-mediated gene editing for abiotic stress management in crop plants
Frontiers in Plant Science, 2023 Abiotic stresses, including drought, salinity, cold, heat, and heavy metals, extensively reducing global agricultural production. Traditional breeding approaches and transgenic technology have been widely used to mitigate the risks of these environmental
M. Kumar +6 more
semanticscholar +1 more source
RNA Targeting and Gene Editing Strategies for Transthyretin Amyloidosis
BioDrugs, 2023 Transthyretin (TTR) is a tetrameric protein synthesized primarily by the liver. TTR can misfold into pathogenic ATTR amyloid fibrils that deposit in the nerves and heart, causing a progressive and debilitating polyneuropathy (PN) and life-threatening ...
A. Ioannou, M. Fontana, J. Gillmore
semanticscholar +1 more source
Establishment of PCR Identification Method for Pig Blood Type
Shiyan dongwu yu bijiao yixue, 2023 ObjectiveXenotransplantation is an effective way to address the shortage of human organ donors, but it faces serious immune rejection reactions, including hyperacute rejection caused by blood type differences.
WANG Jiaoxiang +8 more
doaj +1 more source
Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan
Veterinary Sciences, 2022 Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal +12 more
doaj +1 more source
Reasons and Reproduction: Gene Editing and Genetic Selection
American Journal of Bioethics, 2023 Many writers in bioethics, science, and medicine contend that embryo selection is a morally better way of avoiding genetic disorders then gene editing, as the latter has risks that the former does not. We argue that one reason to use gene editing is that
Jeff McMahan, Julian Savulescu
semanticscholar +1 more source
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer
Molecular Cancer, 2022 Clustered regularly interspaced short palindromic repeats (CRISPR) system provides adaptive immunity against plasmids and phages in prokaryotes. This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated ...
Si-wei Wang +9 more
semanticscholar +1 more source
Nature Nanotechnology, 2020 CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that
Qiang Cheng +5 more
semanticscholar +1 more source
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing
Molecular Cancer, 2022 Chimeric Antigen Receptor (CAR) T-cells represent a breakthrough in personalized cancer therapy. In this strategy, synthetic receptors comprised of antigen recognition, signaling, and costimulatory domains are used to reprogram T-cells to target tumor ...
Alexander J Dimitri +2 more
semanticscholar +1 more source
The Ethics of Germline Gene Editing [PDF]
Journal of Applied Philosophy, 2016 AbstractGermline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development.
Gyngell, Christopher +2 more
openaire +4 more sources
Strategies for mitochondrial gene editing
Computational and Structural Biotechnology Journal, 2021 Mitochondria, as the energy factory of cells, participate in metabolism processes and play a critical role in the maintenance of human life activities. Mitochondria belong to semi-automatic organelles, which have their own genome different from nuclear genome. Mitochondrial DNA (mtDNA) mutations can cause a series of diseases and threaten human health.
Xingbo Yang +4 more
openaire +4 more sources