Results 21 to 30 of about 8,339,405 (403)
Simple Method for Transformation and Gene Editing in Medicinal Plants.
Journal of Integrative Plant Biology, 2023 Gene editing technologies have ushered in a significant advancement in plant genetics research and molecular breeding. However, a critical challenge hindering the widespread adoption of these technologies is the efficient delivery of gene-editing tools ...
Xue-cheng Cao +6 more
semanticscholar +1 more source
Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]
, 2012 Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik +51 more
core +1 more source
Nature Nanotechnology, 2022 Genome editing holds great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of CRISPR/Cas to solid tumours for efficient cancer therapy remains challenging.
Di Zhang +10 more
semanticscholar +1 more source
Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy [PDF]
, 2018 Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD gene.
Amoasii, L +12 more
core +2 more sources
CRISPR/Cas9-gene editing approaches in plant breeding
GM crops & food, 2023 CRISPR/Cas9 gene editing system is recently developed robust genome editing technology for accelerating plant breeding. Various modifications of this editing system have been established for adaptability in plant varieties as well as for its improved ...
Himanshu Saini +4 more
semanticscholar +1 more source
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. [PDF]
, 2017 Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable "base editing" system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase,
Bai, Haipeng +7 more
core +1 more source
Reasons and Reproduction: Gene Editing and Genetic Selection
American Journal of Bioethics, 2023 Many writers in bioethics, science, and medicine contend that embryo selection is a morally better way of avoiding genetic disorders then gene editing, as the latter has risks that the former does not. We argue that one reason to use gene editing is that
Jeff McMahan, J. Savulescu
semanticscholar +1 more source
Efficient generation of brain organoids using magnetized gold nanoparticles
Scientific Reports, 2023 Brain organoids, which are three-dimensional cell culture models, have the ability to mimic certain structural and functional aspects of the human brain.
Hongwon Kim +3 more
doaj +1 more source
Translational Neurodegeneration, 2022 Background The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerates amyloid-beta (Aβ) deposition
Hongwon Kim +4 more
doaj +1 more source
CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer
Cellular & Molecular Biology Letters, 2022 The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, including cancers, by the CRISPR/Cas9 system.
Mostafa Vaghari-Tabari +7 more
semanticscholar +1 more source