Results 31 to 40 of about 1,009,200 (260)
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. [PDF]
, 2018 Engineering of the Cpf1 crRNA has the potential to enhance its gene editing efficiency and non-viral delivery to cells. Here, we demonstrate that extending the length of its crRNA at the 5 end can enhance the gene editing efficiency of Cpf1 both in cells
Chong, Anthony +10 more
core +2 more sources
, 2023 Gene editing allows scientists to modify an organism's DNA with unparalleled precision, utilizing techniques like CRISPR-Cas9. It aids researchers to target specific genes, enhance desirable traits, correct genetic disorders, and develop innovative therapies.
openaire +2 more sources
The origin of unwanted editing byproducts in gene editing
Acta Biochimica et Biophysica Sinica, 2022 The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA breaks at the target sites and subsequently the DNA repair pathways are recruited to generate diverse editing outcomes.
Yin Jianhang, Hu Jiazhi
openaire +3 more sources
Improved genome editing in human cell lines using the CRISPR method [PDF]
, 2014 The Cas9/CRISPR system has become a popular choice for genome editing. In this system, binding of a single guide (sg) RNA to a cognate genomic sequence enables the Cas9 nuclease to induce a double-strand break at that locus.
AW Briggs +22 more
core +7 more sources
NG peptides: A novel family of neurophysin-associated neuropeptides [PDF]
, 2010 NOTICE: this is the author’s version of a work that was accepted for publication in GENE. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be ...
Bromham +20 more
core +1 more source
, 2023 Creative Bioarray is an experienced and outstanding provider of iPSCs Gene Editing service. We are dedicated to providing quality data and comprehensive service for your scientific research, and we are pleased to use our extensive experience and advanced platform to offer the best service to satisfy each demand from our customers.
openaire +4 more sources
Is Gene Editing Patentable? [PDF]
AMA Journal of Ethics, 2019 Gene editing technologies offer enormous potential for scientific advancement in fields such as medicine and agriculture, but their use also raises serious ethical and public policy concerns. Although advisory groups like the World Health Organization question whether certain forms of gene editing should be permitted, the US Patent Office routinely ...
openaire +3 more sources
Nature Communications, 2022 Prime editors can mediate all twelve types of base substitutions and small insertions or deletions in living cells but its efficiency remains low. Here the authors introduce same-sense mutations into pegRNAs to increase base-editing efficiency and the ...
Xiaosa Li +17 more
doaj +1 more source
HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Viruses, 2022 So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes.
Svetlana Kalinichenko +2 more
doaj +1 more source
Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing. [PDF]
, 2019 The determination of null- or low-expressed HLA alleles is clinically relevant in both hematopoietic stem cell transplantation and solid organ transplantation.
Reed, Elaine F +2 more
core +1 more source