Results 41 to 50 of about 1,009,200 (260)

Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi. [PDF]

, 2019
Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood.
Ahrendt, Steven, Blanchette, Robert A, Cullen, Daniel, Gaskell, Jill, Grigoriev, Igor V, Hibbett, David S, Master, Emma, Schilling, Jonathan S, Toapanta, Christina, Wu, Baojun, Zhang, Jiwei   +10 more
core   +1 more source

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. [PDF]

, 2020
With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in ...
Chen, Qu, Fu, Xuemei, Kim, Jinchul, Liu, Jingfeng, Tang, Qingshuang, Xu, Shuxiang, Xu, Yang   +6 more
core  

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells. [PDF]

, 2019
Repurposed CRISPR-Cas molecules provide a useful tool set for broad applications of genomic editing and regulation of gene expression in prokaryotes and eukaryotes. Recent discovery of phage-derived proteins, anti-CRISPRs, which serve to abrogate natural
Abbott, Timothy R, Bondy-Denomy, Joseph, Carter, Matthew A, Chavez, Michael, Dominguez, Antonia A, Gao, Yuchen, Kipniss, Nathan H, La Russa, Marie, Lau, Matthew B, Nakamura, Muneaki, Qi, Lei S, Smolke, Christina D, Srinivasan, Prashanth, Xu, Xiaoshu, Zhao, Dehua   +14 more
core   +3 more sources

The hallmarks of dietary intervention-resilient gut microbiome

npj Biofilms and Microbiomes, 2022
Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko, Vera E. Odintsova, Anastasia Revel-Muroz, Alexander V. Tyakht   +3 more
doaj   +1 more source

Practical guidance for the implementation of the CRISPR genome editing tool in filamentous fungi [PDF]

, 2019
Background: Within the last years, numerous reports described successful application of the CRISPR nucleases Cas9 and Cpf1 for genome editing in filamentous fungi.
Haefner, Stefan, Kwon, Jin, Meyer, Vera, Schütze, Tabea, Spohner, Sebastian   +4 more
core   +1 more source

Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE [PDF]

, 2018
Technological developments in gene editing raise high expectations for clinical applications, including editing of the germline. The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together ...
Angus Clarke, Basil C. Tarlatzis, Björn Heindryckx, Carla G. van El, Dragica Radojkovic, Emmanuelle Rial-Sebbag, Francesca Forzano, Guido De Wert, Guido Pennings, Heidi C. Howard, Mariëtte Goddijn, Martina C. Cornel, null null, Ursula Eichenlaub-Ritter, Wybo Dondorp   +14 more
core   +7 more sources

The gene-editing of super-ego [PDF]

Medicine, Health Care and Philosophy, 2018
New emerging biotechnologies, such as gene editing, vastly extend our ability to alter the human being. This comes together with strong aspirations to improve humans not only physically, but also mentally, morally, and socially. These conjoined ambitions aggregate to what can be labelled "the gene editing of super-ego." This article investigates a ...
openaire   +6 more sources

Gene editing

Postępy Biochemii, 2018
Development of the gene engineering techniques has raised worries that they will be used for construction of organism endangering humansand environment. In 1975 at the Asilomar conference, geneticists from many countries decided that genetic engineering brings more benefitsthan threats. In last years a new CRISPR-Cas technique emerged .
openaire   +3 more sources

Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex

Molecular Therapy: Nucleic Acids, 2018
CD34+ cells are prime targets for therapeutic strategies for gene editing, because modified progenitor cells have the capacity to differentiate through an erythropoietic lineage.
Shirin R. Modarai, Dula Man, Pawel Bialk, Natalia Rivera-Torres, Kevin Bloh, Eric B. Kmiec   +5 more
doaj   +1 more source

Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing

Genome Biology
Chromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang, Pengchong Fu, Ziheng Chen, Xiangnan Wang, Hanhui Ma, Xuedi Zhang, Guanjun Gao   +6 more
doaj   +1 more source