Results 41 to 50 of about 1,118,644 (205)

The hallmarks of dietary intervention-resilient gut microbiome

npj Biofilms and Microbiomes, 2022
Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko, Vera E. Odintsova, Anastasia Revel-Muroz, Alexander V. Tyakht   +3 more
doaj   +1 more source

Gene editing [PDF]

Nature Biotechnology, 2020
Clévio Nóbrega, Liliana Mendonça, Carlos A. Matos   +2 more
openaire   +3 more sources

Gene Editing and Journal Editing [PDF]

The New Bioethics, 2018
Editorial for special issue of The New Bioethics dedicated to the ethics of genomic ...
openaire   +1 more source

Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing

Genome Biology
Chromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang, Pengchong Fu, Ziheng Chen, Xiangnan Wang, Hanhui Ma, Xuedi Zhang, Guanjun Gao   +6 more
doaj   +1 more source

Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE [PDF]

, 2018
Technological developments in gene editing raise high expectations for clinical applications, including editing of the germline. The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together ...
Angus Clarke, Basil C. Tarlatzis, Björn Heindryckx, Carla G. van El, Dragica Radojkovic, Emmanuelle Rial-Sebbag, Francesca Forzano, Guido De Wert, Guido Pennings, Heidi C. Howard, Mariëtte Goddijn, Martina C. Cornel, null null, Ursula Eichenlaub-Ritter, Wybo Dondorp   +14 more
core   +7 more sources

Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex

Molecular Therapy: Nucleic Acids, 2018
CD34+ cells are prime targets for therapeutic strategies for gene editing, because modified progenitor cells have the capacity to differentiate through an erythropoietic lineage.
Shirin R. Modarai, Dula Man, Pawel Bialk, Natalia Rivera-Torres, Kevin Bloh, Eric B. Kmiec   +5 more
doaj   +1 more source

High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of NCED4 in Lettuce (Lactuca sativa). [PDF]

, 2018
CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary transformants. However, many of the mutations analyzed were somatic and therefore not heritable.
Bertier, Lien D, Bradford, Kent J, Britt, Anne B, Huo, Heqiang, Michelmore, Richard W, Ron, Mily   +5 more
core   +2 more sources

Preliminary Study on Construction Method of Type 1 Diabetes Model in Banna Miniature Pig

Shiyan dongwu yu bijiao yixue
Objective To construct a Type 1 diabetes model in miniature pigs and explore postoperative care strategies for effectively prolonging the survival time of the model pigs. Methods Seven Banna miniature pigs were selected for pancreatectomy.
LIU Kai, HU Yuqi, GENG Yatian, CHENG Wenjie, WANG Jing, WEI Taiyun, ZHAO Hongfang, LI Jiayu, JIAO Deling, ZHAO Hongye, WEI Hongjiang   +10 more
doaj   +1 more source

Efficient targeted DNA editing and replacement in Chlamydomonas reinhardtii using Cpf1 ribonucleoproteins and single-stranded DNA [PDF]

, 2017
Significance Our findings establish a method of efficient, targeted genome editing in Chlamydomonas reinhardtii .
Ferenczi, Aron, Molnar, Attila, Pyott, Douglas Euan, Xipnitou, Andromachi   +3 more
core   +2 more sources

Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model

Biological Research
Background Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal, Yixiao Cheng, Deling Jiao, Wen Cheng, Di Zou, Xia Wang, Taiyun Wei, Jianxiong Guo, Kaixiang Xu, Heng Zhao, Shaoxia Pu, Chang Yang, Yubo Qing, Baoyu Jia, Honghui Li, Rusong Zhao, Hong-Ye Zhao, Hong-Jiang Wei   +17 more
doaj   +1 more source