Results 41 to 50 of about 7,473,287 (361)
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences
Nature Cell Biology, 2022 Gene editing is a powerful tool for genome and cell engineering. Exemplified by CRISPR–Cas, gene editing could cause DNA damage and trigger DNA repair processes that are often error-prone.
Chengkun Wang +6 more
semanticscholar +1 more source
Rad50 mediates DNA demethylation to establish pluripotent reprogramming
Experimental and Molecular Medicine, 2020 Regenerative medicine: Protein boosts stem cell generation process Heightened expression of a DNA repair protein improves efficiency when generating induced pluripotent stem cells (iPSCs) for use in regenerative medicine.
Hanseul Park +2 more
doaj +1 more source
Gene Editing and Journal Editing [PDF]
The New Bioethics, 2018 Editorial for special issue of The New Bioethics dedicated to the ethics of genomic ...
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Advances in Delivery Mechanisms of CRISPR Gene-Editing Reagents in Plants
Frontiers in Genome Editing, 2022 Gene-editing by CRISPR/Cas systems has revolutionized plant biology by serving as a functional genomics tool. It has tremendously advanced plant breeding and crop improvement by accelerating the development of improved cultivars, creating genetic ...
Larissa Laforest, S. S. Nadakuduti
semanticscholar +1 more source
, 2023 Gene editing allows scientists to modify an organism's DNA with unparalleled precision, utilizing techniques like CRISPR-Cas9. It aids researchers to target specific genes, enhance desirable traits, correct genetic disorders, and develop innovative therapies.
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The origin of unwanted editing byproducts in gene editing
Acta Biochimica et Biophysica Sinica, 2022 The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA breaks at the target sites and subsequently the DNA repair pathways are recruited to generate diverse editing outcomes.
Yin Jianhang, Hu Jiazhi
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Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering
Cells, 2022 CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in many areas. For safe therapeutic applications in clinical medicine, its off-target effect must be dramatically minimized.
Xiaoqiang Huang +4 more
semanticscholar +1 more source
Endogenous leptin promotes autophagy in EBSS-induced PFCs
Animal Cells and Systems, 2019 Leptin is an important adipokine and plays a vital role in animals. However, the role of leptin in the autophagic response of pig fibroblast cells (PFCs) has not been fully elucidated.
Deling Jiao +10 more
doaj +1 more source
, 2023 Creative Bioarray is an experienced and outstanding provider of iPSCs Gene Editing service. We are dedicated to providing quality data and comprehensive service for your scientific research, and we are pleased to use our extensive experience and advanced platform to offer the best service to satisfy each demand from our customers.
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Is Gene Editing Patentable? [PDF]
AMA Journal of Ethics, 2019 Gene editing technologies offer enormous potential for scientific advancement in fields such as medicine and agriculture, but their use also raises serious ethical and public policy concerns. Although advisory groups like the World Health Organization question whether certain forms of gene editing should be permitted, the US Patent Office routinely ...
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