Results 51 to 60 of about 1,009,200 (260)
Gene editing for inflammatory disorders [PDF]
Annals of the Rheumatic Diseases, 2019 Technology for precise and efficient genetic editing is constantly evolving and is now capable of human clinical applications. Autoimmune and inflammatory diseases are chronic, disabling, sometimes life-threatening, conditions that feature heritable components.
Clifford J. Steer +2 more
openaire +2 more sources
Preliminary Study on Construction Method of Type 1 Diabetes Model in Banna Miniature Pig
Shiyan dongwu yu bijiao yixueObjective To construct a Type 1 diabetes model in miniature pigs and explore postoperative care strategies for effectively prolonging the survival time of the model pigs. Methods Seven Banna miniature pigs were selected for pancreatectomy.
LIU Kai +10 more
doaj +1 more source
High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of NCED4 in Lettuce (Lactuca sativa). [PDF]
, 2018 CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary transformants. However, many of the mutations analyzed were somatic and therefore not heritable.
Bertier, Lien D +5 more
core +2 more sources
CRISPR Gene Editing in Strawberry
EDIS, 2018 Because cultivated strawberries are genetically complex, conventional breeding of strawberry can be difficult. Therefore, gene editing can be useful when developing strawberry varieties. This 3-page document discusses CRISPR gene editing in strawberry. Written by Seonghee Lee, Cheolmin Yoo, Kevin Folta, and Vance M.
Vance Whitaker +3 more
openaire +5 more sources
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Biological ResearchBackground Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal +17 more
doaj +1 more source
Imaging cell lineage with a synthetic digital recording system [PDF]
, 2020 Cell lineage plays a pivotal role in cell fate determination. Chow et al. demonstrate the use of an integrase-based synthetic barcode system called intMEMOIR, which uses the serine integrase Bxb1 to perform irreversible nucleotide edits.
Budde, Mark W. +11 more
core +1 more source
Bacteria herald a new era of gene editing. [PDF]
, 2013 The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome ...
Segal, David J
core
Therapeutic Gene Editing for Hemoglobinopathies. [PDF]
Mediterr J Hematol Infect DisIn the last ten years, a consistent number of clinical studies have evaluated different gene approaches for the treatment of patients with sickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT). Initial studies of gene therapy for hemoglobinopathies involved the use of lentiviral vectors to add functional copies of the gene encoding β ...
Testa U, Leone G, Cappellini MD.
europepmc +4 more sources
Genome Editing with Crispr-Cas9 Systems: Basic Research and Clinical Applications [PDF]
, 2017 BACKGROUND: Recently established genome editing technologies will open new avenues for biological research and development. Human genome editing is a powerful tool which offers great scientific and therapeutic potential.CONTENT: Genome editing using the ...
Dewi, N. M. (Nurrani) +2 more
core +4 more sources
Generation of RAG2 Knockout Immune-Deficient Miniature Pigs
AnimalsRecombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared to ...
Jing Wang +8 more
doaj +1 more source