Results 51 to 60 of about 7,473,287 (361)
Molecular Cancer, 2021 The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRISPR/Cas9) gene editing technology that ...
Huimin Zhang +11 more
semanticscholar +1 more source
Nature Communications, 2022 Prime editors can mediate all twelve types of base substitutions and small insertions or deletions in living cells but its efficiency remains low. Here the authors introduce same-sense mutations into pegRNAs to increase base-editing efficiency and the ...
Xiaosa Li +17 more
doaj +1 more source
HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Viruses, 2022 So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes.
Svetlana Kalinichenko +2 more
doaj +1 more source
“Usage a CRISPR/Cas9-based for obtaining knockouts of economically significant cattle genes” [PDF]
E3S Web of Conferences, 2023 An experimental work dealing with the gene modification using the Cas9 RNA-based editing system was performed. Point site-specific breakpoints in gDNA were introduced at the zygote stage by microinjection of spCas9 mRNA protein and guide RNAs into the ...
Bruter A. +5 more
doaj +1 more source
Spatiotemporal control of CRISPR/Cas9 gene editing
Signal Transduction and Targeted Therapy, 2021 The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic engineering, offers a promising platform to improve the treatment of various ...
Chenya Zhuo +8 more
semanticscholar +1 more source
Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics
Precision Clinical Medicine, 2021 Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems (Cas) are efficient tools for targeting specific genes for laboratory research, agricultural engineering, biotechnology, and human disease treatment.
Wenyi Liu +4 more
semanticscholar +1 more source
The hallmarks of dietary intervention-resilient gut microbiome
npj Biofilms and Microbiomes, 2022 Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko +3 more
doaj +1 more source
The gene-editing of super-ego [PDF]
Medicine, Health Care and Philosophy, 2018 New emerging biotechnologies, such as gene editing, vastly extend our ability to alter the human being. This comes together with strong aspirations to improve humans not only physically, but also mentally, morally, and socially. These conjoined ambitions aggregate to what can be labelled "the gene editing of super-ego." This article investigates a ...
openaire +6 more sources
Application of Gene Editing for Climate Change in Agriculture
Frontiers in Sustainable Food Systems, 2021 Climate change imposes a severe threat to agricultural systems, food security, and human nutrition. Meanwhile, efforts in crop and livestock gene editing have been undertaken to improve performance across a range of traits.
Nicholas G. Karavolias +3 more
semanticscholar +1 more source
Molecular Therapy: Nucleic Acids, 2018 CD34+ cells are prime targets for therapeutic strategies for gene editing, because modified progenitor cells have the capacity to differentiate through an erythropoietic lineage.
Shirin R. Modarai +5 more
doaj +1 more source