Results 61 to 70 of about 1,118,644 (205)
Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9 [PDF]
, 2018 Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons.
Cappellari, O +9 more
core +2 more sources
BMC Plant BiologyThe major latex protein (MLP) gene family, which is part of the Bet v 1 superfamily, is known for its roles in plant development and stress responses. However, the MLP gene family in soybean (Glycine max) remains insufficiently characterized.
Xiaocen Ma +7 more
doaj +1 more source
CRISPR-Cas9 ribonucleoprotein-mediated co-editing and counterselection in the rice blast fungus [PDF]
, 2001 The rice blast fungus Magnaporthe oryzae is the most serious pathogen of cultivated rice and a significant threat to global food security. To accelerate targeted mutation and specific genome editing in this species, we have developed a rapid plasmid-free
Foster, Andrew J. +5 more
core +4 more sources
Genome BiologyCRISPR screens with single-cell transcriptomic readouts are a valuable tool to understand the effect of genetic perturbations including single nucleotide variants (SNVs) associated with diseases.
Sarah E. Cooper +7 more
doaj +1 more source
Genome Editing of the Octoploid Fragaria x ananassa Using the CRISPR/Cas9 System [PDF]
, 2017 Due to its octoploid nature, gene functional analyses in the cultivated strawberry (Fragaria × ananassa) are commonly carried out via gene silencing using self-complementary “hairpin” double-stranded RNA (RNAi) constructs.
Martín-Pizarro, Carmen, Posé, David
core
CRISPR as a Driving Force: The Model T of Biotechnology [PDF]
, 2016 The CRISPR system for gene editing can break, repair, and replace targeted sections of DNA. Although CRISPR gene editing has important therapeutic potential, it raises several ethical concerns.
Mariscal, Carlos, Petropanagos, Angel
core +1 more source
BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma
Advanced ScienceEZH2 is the catalytic subunit of the histone methyltransferase Polycomb Repressive Complex 2 (PRC2), and its somatic activating mutations drive lymphoma, particularly the germinal center B‐cell type.
Dongdong Liu +11 more
doaj +1 more source
A case of prenatal diagnosis of 18p deletion syndrome following noninvasive prenatal testing
Molecular Cytogenetics, 2019 Background Chromosome 18p deletion syndrome is a disease caused by the complete or partial deletion of the short arm of chromosome 18, there were few cases reported about the prenatal diagnosis of 18p deletion syndrome. Noninvasive prenatal testing (NIPT)
Ganye Zhao +6 more
doaj +1 more source
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]
, 2020 A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D +14 more
core +1 more source
TALEN-mediated editing of the mouse Y chromosome [PDF]
, 2013 The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to ...
A Mayer +26 more
core +1 more source