Results 61 to 70 of about 7,473,287 (361)
Postępy Biochemii, 2018 Development of the gene engineering techniques has raised worries that they will be used for construction of organism endangering humansand environment. In 1975 at the Asilomar conference, geneticists from many countries decided that genetic engineering brings more benefitsthan threats. In last years a new CRISPR-Cas technique emerged .
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Multiplexed CRISPR technologies for gene editing and transcriptional regulation
Nature Communications, 2020 Multiplexed CRISPR technologies, in which numerous gRNAs or Cas enzymes are expressed at once, have facilitated powerful biological engineering applications, vastly enhancing the scope and efficiencies of genetic editing and transcriptional regulation ...
Nicholas S. McCarty +3 more
semanticscholar +1 more source
Can gene editing reduce postharvest waste and loss of fruit, vegetables, and ornamentals?
Horticulture Research, 2021 Postharvest waste and loss of horticultural crops exacerbates the agricultural problems facing humankind and will continue to do so in the next decade.
E. Shipman +4 more
semanticscholar +1 more source
Effects of chronic browsing on life‐history traits of an irruptive large herbivore population
Population Ecology, EarlyView.This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji +9 more
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FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Genome BiologyChromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang +6 more
doaj +1 more source
Preliminary Study on Construction Method of Type 1 Diabetes Model in Banna Miniature Pig
Shiyan dongwu yu bijiao yixueObjective To construct a Type 1 diabetes model in miniature pigs and explore postoperative care strategies for effectively prolonging the survival time of the model pigs. Methods Seven Banna miniature pigs were selected for pancreatectomy.
LIU Kai +10 more
doaj +1 more source
CRISPR Gene Editing in Strawberry
EDIS, 2018 Because cultivated strawberries are genetically complex, conventional breeding of strawberry can be difficult. Therefore, gene editing can be useful when developing strawberry varieties. This 3-page document discusses CRISPR gene editing in strawberry. Written by Seonghee Lee, Cheolmin Yoo, Kevin Folta, and Vance M.
Vance Whitaker +3 more
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Gene editing for inflammatory disorders [PDF]
Annals of the Rheumatic Diseases, 2019 Technology for precise and efficient genetic editing is constantly evolving and is now capable of human clinical applications. Autoimmune and inflammatory diseases are chronic, disabling, sometimes life-threatening, conditions that feature heritable components.
Clifford J. Steer +2 more
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Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source