Results 1 to 10 of about 6,790,032 (188)

Tumor Radiosensitization by Gene Electrotransfer-Mediated Double Targeting of Tumor Vasculature. [PDF]

Int J Mol Sci, 2023
Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor radiosensitization.
Savarin M, Znidar K, Sersa G, Komel T, Cemazar M, Kamensek U.   +5 more
europepmc   +4 more sources

In Vivo and Ex Vivo Gene Electrotransfer in Ophthalmological Disorders. [PDF]

Biomedicines, 2022
The aim of this document is to present an overview of gene electrotransfer in ophthalmological disorders. In order to ensure an adequate variety of the assessed studies, several electronic databases were considered and studies published between January ...
Fusco R, Perazzolo Gallo G, Di Bernardo E, D'Alessio V, Ronchetti M, Cadossi M, Cadossi R.   +6 more
europepmc   +5 more sources

Gene Immunotherapy of Colon Carcinoma with IL-2 and IL-12 Using Gene Electrotransfer. [PDF]

Int J Mol Sci, 2023
Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines, such as interleukin 2 and interleukin 12, which stimulate immune cells in tumours.
Komel T, Omerzel M, Kamensek U, Znidar K, Lampreht Tratar U, Kranjc Brezar S, Dolinar K, Pirkmajer S, Sersa G, Cemazar M.   +9 more
europepmc   +2 more sources

The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent. [PDF]

Front Immunol, 2023
Introduction In calcium electroporation (CaEP), electroporation enables the cellular uptake of supraphysiological concentrations of Ca2+, causing the induction of cell death.
Lisec B, Markelc B, Ursic Valentinuzzi K, Sersa G, Cemazar M.   +4 more
europepmc   +2 more sources

What We Learned about the Feasibility of Gene Electrotransfer for Vaccination on a Model of COVID-19 Vaccine. [PDF]

Pharmaceutics, 2023
DNA vaccination is one of the emerging approaches for a wide range of applications, including prophylactic vaccination against infectious diseases and therapeutic vaccination against cancer.
Kamensek U, Cemazar M, Kranjc Brezar S, Jesenko T, Kos S, Znidar K, Markelc B, Modic Z, Komel T, Gorse T, Rebersek E, Jakopic H, Sersa G.   +12 more
europepmc   +2 more sources

Gene Electrotransfer Efficiency in 2D and 3D Cancer Cell Models Using Different Electroporation Protocols: A Comparative Study. [PDF]

Pharmaceutics, 2023
Electroporation, a method relying on a pulsed electric field to induce transient cell membrane permeabilization, can be used as a non-viral method to transfer genes in vitro and in vivo.
de Caro A, Bellard E, Kolosnjaj-Tabi J, Golzio M, Rols MP.   +4 more
europepmc   +2 more sources

Electrochemotherapy Plus IL-2+IL-12 Gene Electrotransfer in Spontaneous Inoperable Stage III-IV Canine Oral Malignant Melanoma. [PDF]

Vaccines (Basel), 2023
Electrochemotherapy (ECT) is a standard of care in veterinary and human oncology. The treatment induces a well-characterized local immune response which is not able to induce a systemic response.
Tellado M, De Robertis M, Montagna D, Giovannini D, Salgado S, Michinski S, Signori E, Maglietti F.   +7 more
europepmc   +2 more sources

Limited Efficacy of Nanoparticle-Assisted Electroporation for Membrane Permeabilization and Gene Electrotransfer. [PDF]

Pharmaceutics
Background/Objectives: Nanoparticles (NPs) were previously explored as enhancers in electroporation due to their potential to locally amplify electric fields near cell membranes, with gold nanoparticles (AuNPs) in particular showing promise in improving ...
Polajžer T, Kranjc M, Kralj S, Caf M, Romih R, Hudoklin S, Rocca F, Miklavčič D.   +7 more
europepmc   +2 more sources

Design, Development, and Testing of a Device for Gene Electrotransfer to Skin Cells In Vivo. [PDF]

Pharmaceutics, 2022
Gene electrotransfer (GET) is considered one of the most efficient, safe, reproducible, and cost-effective methods of gene therapy, in which a gene is delivered to the cells in the form of a plasmid DNA vector by a method known as electroporation.
Cvetkoska A, Dermol-Černe J, Miklavčič D, Kranjc Brezar S, Markelc B, Serša G, Reberšek M.   +6 more
europepmc   +2 more sources

Between defence and delivery: the DNA sensing response to gene electrotransfer. [PDF]

Radiol Oncol
Background Gene therapy has emerged as a transformative biomedical approach, offering new therapeutic possibilities from many so far uncurable diseases through the introduction of recombinant nucleic acids into target cells.
Jesenko T, Omerzel M, Heller LC, Cemazar M.   +3 more
europepmc   +2 more sources