Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial protocol [PDF]
Radiology and Oncology, 2022 Immune therapies are currently under intensive investigation providing in many cases excellent responses in different tumors. Other possible approach for immunotherapy is a targeted intratumoral delivery of interleukin 12 (IL-12), a cytokine with anti ...
Groselj Ales +6 more
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Between defence and delivery: the DNA sensing response to gene electrotransfer. [PDF]
Radiol OncolAbstract Background Gene therapy has emerged as a transformative biomedical approach, offering new therapeutic possibilities from many so far uncurable diseases through the introduction of recombinant nucleic acids into target cells.
Jesenko T +3 more
europepmc +4 more sources
Numerical study of gene electrotransfer efficiency based on electroporation volume and electrophoretic movement of plasmid DNA [PDF]
BioMedical Engineering OnLine, 2018 Background The efficiency of gene electrotransfer, an electroporation-based method for delivery of pDNA into target tissues, depends on several processes.
Tadeja Forjanič, Damijan Miklavčič
doaj +2 more sources
BioMedical Engineering OnLine, 2007 Background Gene electrotransfer is a non-viral method used to transfer genes into living cells by means of high-voltage electric pulses. An exposure of a cell to an adequate amplitude and duration of electric pulses leads to a temporary increase of cell ...
Rols Marie-Pierre +6 more
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Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer [PDF]
Advanced ScienceViral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics.
Jeremy L. Pinyon +13 more
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Limited Efficacy of Nanoparticle-Assisted Electroporation for Membrane Permeabilization and Gene Electrotransfer [PDF]
PharmaceuticsBackground/Objectives: Nanoparticles (NPs) were previously explored as enhancers in electroporation due to their potential to locally amplify electric fields near cell membranes, with gold nanoparticles (AuNPs) in particular showing promise in improving ...
Tamara Polajžer +7 more
doaj +2 more sources
Molecular Therapy: Methods & Clinical Development, 2014 DNA vaccination consists in administering an antigen-encoding plasmid in order to trigger a specific immune response. This specific vaccine strategy is of particular interest to fight against various infectious diseases and cancer.
Christophe Y Calvet +7 more
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Gene Immunotherapy of Colon Carcinoma with IL-2 and IL-12 Using Gene Electrotransfer [PDF]
International Journal of Molecular Sciences, 2023 Masa Omerzel +2 more
exaly +2 more sources
Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: a histopathologic and immunohistochemical study [PDF]
Radiology and Oncology, 2017 The study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumors (MCT).
Salvadori Claudia +9 more
doaj +2 more sources
Gene Electrotransfer Efficiency in 2D and 3D Cancer Cell Models Using Different Electroporation Protocols: A Comparative Study [PDF]
Pharmaceutics, 2023 Jelena Kolosnjaj-Tabi +2 more
exaly +2 more sources