Results 21 to 30 of about 4,599 (157)
Thermal Assisted In Vivo Gene Electrotransfer. [PDF]
Curr Gene Ther, 2016 Gene electrotransfer is an effective approach for delivering plasmid DNA to a variety of tissues. Delivery of molecules with electric pulses requires control of the electrical parameters to achieve effective delivery. Since discomfort or tissue damage may occur with high applied voltage, the reduction of the applied voltage while achieving the desired ...
Donate A +8 more
europepmc +5 more sources
Noninvasive Gene Electrotransfer in Skin [PDF]
Human Gene Therapy Methods, 2019 The skin is considered as well suited for gene therapy and vaccination. DNA vaccines elicit both broad humoral and cellular immune responses when injected in the skin. Physical and chemical methods are needed to boost the expression. Gene electrotransfer (GET) is one of the most effective approaches.
Lise, Pasquet +5 more
openaire +2 more sources
Acute Effects of Intratumor DNA Electrotransfer
Pharmaceutics, 2022 Intratumor therapeutic DNA electroporation or electrotransfer is in clinical trials in the United States and is under development in many other countries.
Manya Bhandary +3 more
doaj +1 more source
Between defence and delivery: the DNA sensing response to gene electrotransfer. [PDF]
Radiol OncolAbstract Background Gene therapy has emerged as a transformative biomedical approach, offering new therapeutic possibilities from many so far uncurable diseases through the introduction of recombinant nucleic acids into target cells.
Jesenko T +3 more
europepmc +4 more sources
Calcium Electroporation of Equine Sarcoids
Animals, 2020 Sarcoids are common equine skin tumors where the risk of recurrence after treatment is high, and better treatment options are warranted. Calcium electroporation is a novel anti-cancer treatment where lethally high calcium concentrations are introduced ...
Stine K. Frandsen +3 more
doaj +1 more source
The Influence of Calcium Ions on the Electrotransfer Efficiency of Plasmid DNA and Cell Viability
Applied Sciences, 2023 Gene electrotransfer (GET) is recognized as a promising technique for the development of an efficient tool for gene therapy. Such a therapy would have applications in the treatment of a variety of genetic diseases, including cancer.
Rūta Palepšienė +4 more
doaj +1 more source
IL-12 Gene Electrotransfer Triggers a Change in Immune Response within Mouse Tumors [PDF]
Cancers, 2018 Richard Heller +2 more
exaly +2 more sources
Gene electrotransfer: Potential for gene therapy of renal diseases [PDF]
Kidney International, 2002 The ability to pursue gene therapy has been limited by the availability of an effective and safe system for gene delivery, especially to the kidney. Electroporation is an efficient method to transfer physiologically the gene to the cells without complicated preparation.
Imai, Enyu, Isaka, Yoshitaka
openaire +2 more sources
Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma
BMC Cancer, 2013 Background Interleukin-12 (IL-12) based radiosensitization is an effective way of tumor treatment. Local cytokine production, without systemic shedding, might provide clinical benefit in radiation treatment of sarcomas.
Sedlar Ales +5 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2014 DNA vaccination consists in administering an antigen-encoding plasmid in order to trigger a specific immune response. This specific vaccine strategy is of particular interest to fight against various infectious diseases and cancer.
Christophe Y Calvet +7 more
doaj +1 more source