Gene electrotransfer enhanced by nanosecond pulsed electric fields [PDF]
Molecular Therapy: Methods & Clinical Development, 2014 The impact of nanosecond pulsed electric fields (nsPEFs) on gene electrotransfer has not been clearly demonstrated in previous studies. This study was conducted to evaluate the influence of nsPEFs on the delivery of plasmids encoding luciferase or green ...
Siqi Guo +5 more
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Numerical optimization of gene electrotransfer into muscle tissue [PDF]
BioMedical Engineering OnLine, 2010 Background Electroporation-based gene therapy and DNA vaccination are promising medical applications that depend on transfer of pDNA into target tissues with use of electric pulses.
Miklavcic Damijan +3 more
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Numerical study of gene electrotransfer efficiency based on electroporation volume and electrophoretic movement of plasmid DNA [PDF]
BioMedical Engineering OnLine, 2018 Background The efficiency of gene electrotransfer, an electroporation-based method for delivery of pDNA into target tissues, depends on several processes.
Tadeja Forjanič, Damijan Miklavčič
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Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer [PDF]
Advanced ScienceViral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics.
Jeremy L. Pinyon +13 more
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Limited Efficacy of Nanoparticle-Assisted Electroporation for Membrane Permeabilization and Gene Electrotransfer [PDF]
PharmaceuticsBackground/Objectives: Nanoparticles (NPs) were previously explored as enhancers in electroporation due to their potential to locally amplify electric fields near cell membranes, with gold nanoparticles (AuNPs) in particular showing promise in improving ...
Tamara Polajžer +7 more
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Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: a histopathologic and immunohistochemical study [PDF]
Radiology and Oncology, 2017 The study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumors (MCT).
Salvadori Claudia +9 more
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Gene Immunotherapy of Colon Carcinoma with IL-2 and IL-12 Using Gene Electrotransfer [PDF]
International Journal of Molecular Sciences, 2023 Masa Omerzel +2 more
exaly +2 more sources
Case Reports in Dermatology, 2022 We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years.
Katrine Borres Jensen +3 more
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Gene Electrotransfer: A Mechanistic Perspective. [PDF]
Curr Gene Ther, 2016 Gene electrotransfer is a powerful method of DNA delivery offering several medical applications, among the most promising of which are DNA vaccination and gene therapy for cancer treatment. Electroporation entails the application of electric fields to cells which then experience a local and transient change of membrane permeability.
Rosazza C +4 more
europepmc +4 more sources
Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array. [PDF]
PLoS ONE, 2013 Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently
Siqi Guo +4 more
doaj +1 more source