Results 91 to 100 of about 7,937 (203)

Amplifying Anti‐Tumor Immune Responses via Mitochondria‐Targeting Near‐Infrared Photodynamic Therapy

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Interfacial Nd3+‐triplet energy transfer enables direct activation of molecular triplets under near‐infrared (NIR) irradiation for reactive oxygen species (ROS) generation. Photodynamic therapy (PDT) exaggerates hypoxia, which initiates subsequent hypoxia‐activated chemotherapy.
Cheng‐Ao Li, Junjie Nan, Qingxuan Ye, Bingzhu Zheng, Xiaomeng Dai, Jingya Li, Feng Wang, Huimin Ma, Yu Cheng, Jian Ruan, Weijia Fang, Peng Zhao, Renren Deng, Dong Cen   +13 more
wiley   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, Volume 12, Issue 35, September 18, 2025.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Canstatin gene electrotransfer combined with radiotherapy: preclinical trials for cancer treatment [PDF]

Gene Therapy, 2008
Given as a prophylactic treatment, a single muscle electrogene transfer of plasmid coding canstatin fused to human serum albumin (CanHSA), slowed down the development of two xenografted human carcinomas from mammary (MDA-MB-231) and prostate origin (PC-3) in nude mice and delayed lung metastatic spreading of B16F10 melanoma cells in syngenic mice.
Magnon, C., Opolon, P., Connault, E., Mir, L. M., Perricaudet, M., Martel-Renoir, D.   +5 more
openaire   +3 more sources

OsDUF2488 acts synergistically with OsPrx1.1, regulates ROS metabolism and promotes dehydration tolerance in rice

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3879-3899, September 2025.
Summary Stress‐mediated regulation of energy metabolism and its relation to plant adaptation remain largely unknown. Mitochondrial redox potential is greatly influenced by stress‐induced reactive oxygen species (ROS); therefore, we mapped the dehydration‐induced alterations in the mitochondrial proteome of a resilient rice cultivar, Rasi, generating a ...
Dipak Gayen, Sunil Kumar, Pragya Barua, Nilesh Vikram Lande, Subhasis Karmakar, Amit K. Dey, Saurabh Gayali, Tushar Kanti Maiti, Kutubuddin Ali Molla, Snehal Murumkar, Subhra Chakraborty, Niranjan Chakraborty   +11 more
wiley   +1 more source

Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations

BioMedical Engineering OnLine, 2007
Background Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or genes into target cells based on the cell membrane ...
Pavlin Mojca, Čorović Selma, Miklavčič Damijan   +2 more
doaj   +1 more source

NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]

, 2006
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David, Boldin, Mark P., Chang, Kuang-Jung, Taganov, Konstantin D.   +3 more
core  

Education on electrical phenomena involved in electroporation-based therapies and treatments: a blended learning approach [PDF]

, 2016
BACKGROUND: Electroporation-based applications require multidisciplinary expertise and collaboration of experts with different professional backgrounds in engineering and science.
Damijan Miklavčič, Samo Mahnič-Kalamiza, Selma Čorović   +2 more
core   +1 more source

Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR‐Induced AMPK Activation and Glucose Uptake in L6 Myotubes

BioFactors, Volume 51, Issue 4, July/August 2025.
Mycophenolate mofetil, alanosine, trimetrexate, and sulfamethoxazole mimic methotrexate's effects by enhancing AICAR‐induced AMPK activation and glucose uptake in L6 myotubes. Collectively, our results suggest that IMP metabolism may serve as a gateway for the modulation of AMPK and its metabolic effects in skeletal muscle cells. ABSTRACT Methotrexate,
Klemen Dolinar, Katarina Miš, Katja Šopar, Mateja Šutar, Meta Božič, Matic Kolar, Tim Hropot, Pablo M. Garcia‐Roves, Alexander V. Chibalin, Sergej Pirkmajer   +9 more
wiley   +1 more source

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Biphasic Gene Electrotransfer Enhances Gene Delivery In Vitro

, 2020
The application of short, pulsed electric fields to eukaryotic cells and tissues has been shown to permeabilize cells. This phenomenon has been used for clinical applications for irreversible electroporation of cancer cells or for molecule delivery for drug or gene therapies.
openaire   +2 more sources