Results 91 to 100 of about 6,790,032 (188)
Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.Abstract INTRODUCTION Down syndrome (DS) markedly raises the risk of Alzheimer's disease (DS‐AD). Our findings identified widespread dysregulation of the endolysosomal network (ELN) in DS and DS‐AD brains, driven by increased APP gene dose, hyperactivation of RAB5, and elevated levels of guanine nucleotide exchange factors (GEFs) for RABs 7 and 11 ...
Xu‐Qiao Chen +12 more
wiley +1 more source
Kidney regeneration and repair after transplantation [PDF]
, 2013 PURPOSE OF REVIEW: To briefly show which are the mechanisms and cell types involved in kidney regeneration and describe some of the therapies currently under study in regenerative medicine for kidney transplantation.
Cruzado, J.M. +3 more
core +1 more source
Journal of Clinical Laboratory Analysis, Volume 39, Issue 9, May 2025.New biomarkers are needed to make colorectal cancer (CRC) screening programs more efficient. Cancer cells secrete, in plasma, extracellular vesicles that contain proteins. Matrix Metalloproteinases 14 (MMP14) play a critical role in the initiation and progression of CRC.
Mickaël Barhoum +12 more
wiley +1 more source
The Third Pillar of Precision Medicine — Precision Delivery
MedComm, Volume 6, Issue 5, May 2025.For Precision Medicine to reach its full potential, a third pillar called Precision Delivery is starting to evolve to complement the existing two pillars of Precision Diagnosis and Precision Therapy. Precision Delivery will help ensure the right therapy for the right disease will be able to reach the right location at the right time .
Avnesh S. Thakor
wiley +1 more source
Synthesis of electroneutralized amphiphilic copolymers with peptide dendrons for intramuscular gene delivery [PDF]
, 2016 Intramuscular gene delivery materials are of great importance in plasmid-based gene therapy system, but there is limited information so far on how to design and synthesize them.
Chai, Qiuxia +7 more
core +1 more source
Biomedical application of electroporation: electrochemotherapy and electrogene therapy [PDF]
, 2014 Electroporation refers to exposure of cells to external electric field thatresults in transiently or permanently increased permeability of cell membranes.
Cor, Andrej +4 more
core +1 more source
Cyclodextrin-PEI-Tat Polymer as a Vector for Plasmid DNA Delivery to Placenta Mesenchymal Stem Cells [PDF]
, 2011 This study aims to modify a cyclodextrin-PEI-based polymer, PEI-β-CyD, with the TAT peptide for plasmid DNA delivery to placenta mesenchymal stem cells (PMSCs). By using the disulfide exchange between the SPDP-activated PEI-β-CyD and TAT peptide, the TAT-
Kung, HF +9 more
core +1 more source
The Evaluation of Mefloquine Drug Repurposing on Acute Myeloid Leukemia [PDF]
, 2018 The aim of this study is to observe cell proliferation, cell viability, apoptosis, and autophagy on acute myeloid leukemia (AML) cell lines, NB4 and U937, with the drug repurposing of mefloquine (MQ).
Corey, Seth +3 more
core +1 more source
DNA Electrotransfer: An Effective Tool for Gene Therapy
, 2013 Originally developed for monogenic diseases, and therefore associated with the compensa‐ tion of genes whose alteration is responsible for diseases, the concept of gene therapy has rapidly expanded to the use of DNA as a new type of drug. Therefore, gene therapy leads to indications which are far beyond the case of genetic diseases, since a DNA drug ...
Aurore Burgain-Chain, Daniel Scherm
openaire +4 more sources
Purification and characterization of a 40.8-kDa cutinase in ungerminated conidia of Botrytis cinerea Pers.: Fr [PDF]
, 2017 Cytoplasmic soluble proteins from ungerminated conidia of Botrytis cinerea exhibited cutinase activity. A 40.8-kDa cutinase was purified to homogeneity from this crude conidial protein extract.
Gindro, Katia, Pezet, Roger
core