Results 121 to 130 of about 7,937 (203)

Gene Electrotransfer Efficiency in 2D and 3D Cancer Cell Models Using Different Electroporation Protocols: A Comparative Study. [PDF]

Pharmaceutics, 2023
de Caro A, Bellard E, Kolosnjaj-Tabi J, Golzio M, Rols MP.   +4 more
europepmc   +1 more source

Electrochemotherapy Plus IL-2+IL-12 Gene Electrotransfer in Spontaneous Inoperable Stage III-IV Canine Oral Malignant Melanoma. [PDF]

Vaccines (Basel), 2023
Tellado M, De Robertis M, Montagna D, Giovannini D, Salgado S, Michinski S, Signori E, Maglietti F.   +7 more
europepmc   +1 more source

Efficient gene transfer by pulse parameters for electrochemotherapy of cells in vitro and in muscle and melanoma tumors in mice

Radiology and Oncology
In recent years, various gene therapy strategies have been developed for cancer treatment. One of these strategies is electroporation-based delivery of therapeutic transgenes - gene electrotransfer (GET). Electrochemotherapy and GET have been combined in
Omerzel Masa, Markelc Bostjan, Brezar Simona Kranjc, Sersa Gregor, Cemazar Maja   +4 more
doaj   +1 more source

Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer

Pharmaceutics
Gene therapy approaches may target skeletal muscle due to its high protein-expressing nature and vascularization. Intramuscular plasmid DNA (pDNA) delivery via pulsed electric fields (PEFs) can be termed electroporation or electrotransfer.
Amanda Sales Conniff, Julie Singh, Richard Heller, Loree C. Heller   +3 more
doaj   +1 more source

Real-time impedance feedback to enhance cutaneous gene electrotransfer in a murine skin model. [PDF]

Bioelectrochemistry, 2021
Atkins RM, Fawcett TJ, Gilbert R, Hoff AM, Connolly R, Brown DW, Jaroszeski MJ.   +6 more
europepmc   +1 more source

A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma

Scientific Reports
Our study introduces a novel bacteriophage-based vaccine strategy and evaluates its antitumor efficacy, both as a standalone therapy and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids. Using phage display technology, we
Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Andrej Cör   +3 more
doaj   +1 more source

Moderate Heat-Assisted Gene Electrotransfer as a Potential Delivery Approach for Protein Replacement Therapy through the Skin. [PDF]

Pharmaceutics, 2021
Edelblute C, Mangiamele C, Heller R.
europepmc   +1 more source

Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer. [PDF]

Bioelectrochemistry, 2021
Heller L, Bulysheva A, Arpag S, Sales Conniff A, Kohena K, Shi G, Semenova N, Heller R, Cemazar M.   +8 more
europepmc   +1 more source

Moderate Heat-Assisted Gene Electrotransfer for Cutaneous Delivery of a DNA Vaccine Against Hepatitis B Virus. [PDF]

Hum Gene Ther, 2021
Edelblute C, Mangiamele C, Heller R.
europepmc   +1 more source

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation. [PDF]

Int J Mol Sci, 2021
Savarin M, Kamensek U, Znidar K, Todorovic V, Sersa G, Cemazar M.   +5 more
europepmc   +1 more source