Results 21 to 30 of about 6,790,032 (188)

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation. [PDF]

Int J Mol Sci, 2021
Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an antibiotic resistance gene-free plasmid encoding shRNAs to simultaneously target two endothelial ...
Savarin M, Kamensek U, Znidar K, Todorovic V, Sersa G, Cemazar M.   +5 more
europepmc   +2 more sources

Comparison of Nucleosome, Ferritin and LDH Levels in Blood with Clinical Response before and after Electrochemotherapy Combined with IL-12 Gene Electrotransfer for the Treatment of Mast Cell Tumours in Dogs. [PDF]

Animals (Basel)
Simple Summary This study focused on identifying and evaluating the use of selected potential biomarkers in predicting the treatment response of mast cell tumours (MCT) in dogs using a combination of electrochemotherapy (ECT) and interleukin 12 gene ...
Vilfan M, Lampreht Tratar U, Milevoj N, Nemec Svete A, Čemažar M, Serša G, Tozon N.   +6 more
europepmc   +2 more sources

Moderate Heat-Assisted Gene Electrotransfer for Cutaneous Delivery of a DNA Vaccine Against Hepatitis B Virus. [PDF]

Hum Gene Ther, 2021
An estimated 350 million people are living with chronic Hepatitis B virus (HBV) worldwide. Preventative HBV vaccination in infants has reduced the disease burden; however, insufficient immunization programs and access obstacles leave vulnerable ...
Edelblute C, Mangiamele C, Heller R.
europepmc   +2 more sources

Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024) [PDF]

Advanced science
Vector‐Free Gene Augmentation Therapy In article number 2401392, Jeremy L. Pinyon, Gary D. Housley, and coworkers describe ‘conductivityclamped’ gene electrotransfer (CC‐GET) which broadly enables vector‐free nucleic acid therapeutics.
Jeremy L. Pinyon, Georg von Jonquieres, Edward N. Crawford, A. A. Abed, John M Power, Matthias Klugmann, Cherylea J Browne, D. Housley, Andrew K. Wise, J. B. Fallon, Robert K Shepherd, John Y Lin, Catherine McMahon, D. McAlpine, Catherine S Birman, Waikong Lai, Y. L. Enke, Paul M Carter, James F. Patrick, Robert D Gay, C. Marie, Daniel Scherman, Nigel H. Lovell, G. Housley   +23 more
europepmc   +2 more sources

Health-related quality of life in dogs treated with electrochemotherapy and/or interleukin-12 gene electrotransfer. [PDF]

Vet Med Sci, 2020
The aim of this study was to evaluate the owners' perception of health‐related quality of life (HRQoL) of dogs after treatment with electrochemotherapy (ECT) alone or combined with interleukin‐12 gene electrotransfer (IL‐12 GET) and/or surgery.
Milevoj N, Tozon N, Licen S, Lampreht Tratar U, Sersa G, Cemazar M.   +5 more
europepmc   +2 more sources

Transcriptomic analysis of the immune response to in vivo gene electrotransfer in colorectal cancer. [PDF]

Mol Ther Nucleic Acids
De Robertis M, Bozic T, Santek I, Marzano F, Markelc B, Silvestris DA, Tullo A, Pesole G, Cemazar M, Signori E.   +9 more
europepmc   +2 more sources

Maintenance and gene electrotransfer efficiency of antibiotic resistance gene-free plasmids encoding mouse, canine and human interleukin-12 orthologues. [PDF]

Heliyon, 2022
Kamensek U, Rencelj A, Jesenko T, Remic T, Sersa G, Cemazar M.   +5 more
europepmc   +2 more sources

Gene Electrotransfer: A Mechanistic Perspective. [PDF]

Curr Gene Ther, 2016
Gene electrotransfer is a powerful method of DNA delivery offering several medical applications, among the most promising of which are DNA vaccination and gene therapy for cancer treatment. Electroporation entails the application of electric fields to cells which then experience a local and transient change of membrane permeability.
Rosazza C, Meglic SH, Zumbusch A, Rols MP, Miklavcic D.   +4 more
europepmc   +4 more sources

Thermal Assisted In Vivo Gene Electrotransfer. [PDF]

Curr Gene Ther, 2016
Gene electrotransfer is an effective approach for delivering plasmid DNA to a variety of tissues. Delivery of molecules with electric pulses requires control of the electrical parameters to achieve effective delivery. Since discomfort or tissue damage may occur with high applied voltage, the reduction of the applied voltage while achieving the desired ...
Donate A, Bulysheva A, Edelblute C, Jung D, Malik MA, Guo S, Burcus N, Schoenbach K, Heller R.   +8 more
europepmc   +5 more sources

Gene electrotransfer of FGF2 enhances collagen scaffold biocompatibility.

Bioelectrochemistry, 2021
Tendon injuries are a common athletic injury that have been increasing in prevalence. While there are current clinical treatments for tendon injuries, they have relatively long recovery times and often do not restore native function of the tendon. In the current study, gene electrotransfer (GET) parameters for delivery to the skin were optimized with ...
Carly Boye, Kyle Christensen, Kamal Asadipour, Scott DeClemente, Michael Francis, A. Bulysheva   +5 more
semanticscholar   +4 more sources