Results 21 to 30 of about 7,937 (203)
Effective gene immunotherapy for melanoma utilizing an advanced in vivo electrotransfer system [PDF]
Molecular Therapy: OncologyInterleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ.
Loree C. Heller +8 more
doaj +2 more sources
Case Reports in Dermatology, 2022 We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years.
Katrine Borres Jensen +3 more
doaj +1 more source
Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array. [PDF]
PLoS ONE, 2013 Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently
Siqi Guo +4 more
doaj +1 more source
Noninvasive Gene Electrotransfer in Skin [PDF]
Human Gene Therapy Methods, 2019 The skin is considered as well suited for gene therapy and vaccination. DNA vaccines elicit both broad humoral and cellular immune responses when injected in the skin. Physical and chemical methods are needed to boost the expression. Gene electrotransfer (GET) is one of the most effective approaches.
Lise, Pasquet +5 more
openaire +2 more sources
Acute Effects of Intratumor DNA Electrotransfer
Pharmaceutics, 2022 Intratumor therapeutic DNA electroporation or electrotransfer is in clinical trials in the United States and is under development in many other countries.
Manya Bhandary +3 more
doaj +1 more source
Calcium Electroporation of Equine Sarcoids
Animals, 2020 Sarcoids are common equine skin tumors where the risk of recurrence after treatment is high, and better treatment options are warranted. Calcium electroporation is a novel anti-cancer treatment where lethally high calcium concentrations are introduced ...
Stine K. Frandsen +3 more
doaj +1 more source
The Influence of Calcium Ions on the Electrotransfer Efficiency of Plasmid DNA and Cell Viability
Applied Sciences, 2023 Gene electrotransfer (GET) is recognized as a promising technique for the development of an efficient tool for gene therapy. Such a therapy would have applications in the treatment of a variety of genetic diseases, including cancer.
Rūta Palepšienė +4 more
doaj +1 more source
Applied Sciences, 2022 Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant effectiveness by forming transient pores in the cell membrane using electric pulses. This can be used for cellular transport (RE—reversible electroporation) or
Katarzyna Rakoczy +9 more
doaj +1 more source
Gene electrotransfer: Potential for gene therapy of renal diseases [PDF]
Kidney International, 2002 The ability to pursue gene therapy has been limited by the availability of an effective and safe system for gene delivery, especially to the kidney. Electroporation is an efficient method to transfer physiologically the gene to the cells without complicated preparation.
Imai, Enyu, Isaka, Yoshitaka
openaire +2 more sources
Gene electrotransfer of FGF2 enhances collagen scaffold biocompatibility
Bioelectrochemistry, 2022 Tendon injuries are a common athletic injury that have been increasing in prevalence. While there are current clinical treatments for tendon injuries, they have relatively long recovery times and often do not restore native function of the tendon. In the current study, gene electrotransfer (GET) parameters for delivery to the skin were optimized with ...
Carly Boye +5 more
openaire +3 more sources