Results 61 to 70 of about 6,790,032 (188)
Prednosti i nedostaci različitih pristupa generiranja impulsa za elektroporaciju [PDF]
, 2011 Electroporator is a generator of electric pulses that is used for permeabilization of cells. There are five major concepts of electroporation design.
Damijan Miklavčič, Matej Reberšek
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Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Bachmeier, B. E. +4 more
core +1 more source
Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity
Advanced Science, Volume 12, Issue 48, December 29, 2025.KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao +25 more
wiley +1 more source
Advanced Science, Volume 12, Issue 41, November 6, 2025.PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li +6 more
wiley +1 more source
Food Frontiers, Volume 6, Issue 6, Page 2823-2838, November 2025.Our results indicate that maternal ISO‐S during late gestation and throughout lactation can improve offspring intestinal homeostasis, which may be related to antioxidant enzymes and immunoglobulins in sow colostrum through maternal metabolome–microbiome intestine interactions.
Changming Hong +9 more
wiley +1 more source
A polymerase chain reaction-based methodology to detect gene doping [PDF]
, 2018 The non-therapeutic use of genes to enhance athletic performance (gene doping) is a novel threat to the World of Sports. Skeletal muscle is a prime target of gene therapy and we asked whether we can develop a test system to produce and detect gene doping.
Carter, Adam, Flueck, Martin
core
A Proteolytic Fragment from the Central Region of P53 Has Marked Sequence-Specific DNA-Binding Activity When Generated from Wild-Type but Not from Oncogenic Mutant P53-Protein [PDF]
, 1993 p53 is a sequence-specific DNA-binding oligomeric protein that can activate transcription from promoters bearing p53-binding sites. Whereas the activation region of p53 has been identified within the amino terminus, the location of the specific DNA ...
Bargonetti, J. +4 more
core +1 more source
The FEBS Journal, Volume 292, Issue 19, Page 5046-5066, October 2025.We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika +7 more
wiley +1 more source
Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space [PDF]
, 1992 Cytochrome b2 reaches the intermembrane space of mitochondria by transport into the matrix followed by export across the inner membrane. While in the matrix, the protein interacts with hsp60, which arrests its folding prior to export.
Guiard, Bernard +6 more
core +1 more source
The FEBS Journal, Volume 292, Issue 20, Page 5525-5539, October 2025.A loss of function TNNT1 myopathy mouse model with the nonsense mutation p.E180* showed potential cytotoxicity of the truncated slow troponin T fragment. The mRNA expression profile in the soleus muscle of Tnnt1‐p.E180* mice showed very different changes in comparison to that of Tnnt1‐knockout mice.
Han‐Zhong Feng +2 more
wiley +1 more source