Results 71 to 80 of about 7,937 (203)
Cancer Science, Volume 117, Issue 1, Page 63-77, January 2026.Our findings have revealed that the intracellular SNAPIN interplays with KEAP1 to promote KEAP1 protein degradation via the autophagy‐lysosomal pathway. Accordingly, NRF2 dissociates from KEAP1 for nuclear translocation, thus activating its target gene GPX4.
Xuan Liu +5 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
Vaccines, 2021 Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently
Jean Carlos dos Santos da Luz +5 more
doaj +1 more source
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Objective Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Long noncoding RNAs (lncRNAs) have been documented to play important roles in the pathogenesis of RA. This study is aimed to investigate the differentially expressed lncRNAs in RA and explore the underlying roles and mechanisms of RA‐specific lncRNAs.
Jinjin Chu +10 more
wiley +1 more source
Mcam Silencing With RNA Interference Using Magnetofection has Antitumor Effect in Murine Melanoma
Molecular Therapy: Nucleic Acids, 2014 The melanoma cell adhesion molecule (MCAM) is involved in melanoma development and its progression, including invasiveness, metastatic potential and angiogenesis.
Lara Prosen +5 more
doaj +1 more source
Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity
Advanced Science, Volume 12, Issue 48, December 29, 2025.KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao +25 more
wiley +1 more source
A polymerase chain reaction-based methodology to detect gene doping [PDF]
, 2018 The non-therapeutic use of genes to enhance athletic performance (gene doping) is a novel threat to the World of Sports. Skeletal muscle is a prime target of gene therapy and we asked whether we can develop a test system to produce and detect gene doping.
Carter, Adam, Flueck, Martin
core
Advanced Science, Volume 12, Issue 41, November 6, 2025.PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li +6 more
wiley +1 more source
Frontiers in Neuroscience, 2019 The neural interface is a critical factor in governing efficient and safe charge transfer between a stimulating electrode and biological tissue. The interface plays a crucial role in the efficacy of electric stimulation in chronic implants and both ...
Amr Al Abed +6 more
doaj +1 more source
Scientific Reports, 2021 Gene electrotransfer is an attractive method of non-viral gene delivery. However, the mechanism of DNA penetration across the plasma membrane is widely discussed.
Angela Tesse +2 more
doaj +1 more source