Results 71 to 80 of about 6,790,032 (188)

Amplifying Anti‐Tumor Immune Responses via Mitochondria‐Targeting Near‐Infrared Photodynamic Therapy

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Interfacial Nd3+‐triplet energy transfer enables direct activation of molecular triplets under near‐infrared (NIR) irradiation for reactive oxygen species (ROS) generation. Photodynamic therapy (PDT) exaggerates hypoxia, which initiates subsequent hypoxia‐activated chemotherapy.
Cheng‐Ao Li, Junjie Nan, Qingxuan Ye, Bingzhu Zheng, Xiaomeng Dai, Jingya Li, Feng Wang, Huimin Ma, Yu Cheng, Jian Ruan, Weijia Fang, Peng Zhao, Renren Deng, Dong Cen   +13 more
wiley   +1 more source

Electrotransfer of CpG free plasmids enhances gene expression in skin [PDF]

Bioelectrochemistry, 2019
Skin is a very suitable target for gene therapy and DNA vaccination due to its accessibility, its surface and its ability to produce transgenes. Gene electrotransfer (GET) to the skin is under development for clinical applications for DNA vaccine or local treatment such as wound healing.
S, Chabot, E, Bellard, J P, Reynes, G, Tiraby, J, Teissie, M, Golzio   +5 more
openaire   +2 more sources

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, Volume 12, Issue 35, September 18, 2025.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

ELECTROTRANSFER OF CYTOKINE GENES FOR CANCER TREATMENT

CBU International Conference Proceedings, 2018
Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a physical method for transfecting genes into cells and tissues. Many reports for the utilization of this techniques in animals confirmed that gene electrotransfer is a safe and efficient method.
Sonam Chopra, Saulius Satkauskas
openaire   +1 more source

Endocytosis and Endosomal Trafficking of DNA After Gene Electrotransfer In Vitro. [PDF]

Mol Ther Nucleic Acids, 2016
DNA electrotransfer is a successful technique for gene delivery into cells and represents an attractive alternative to virus-based methods for clinical applications including gene therapy and DNA vaccination. However, little is currently known about the mechanisms governing DNA internalization and its fate inside cells. The objectives of this work were
Rosazza C, Deschout H, Buntz A, Braeckmans K, Rols MP, Zumbusch A.   +5 more
europepmc   +7 more sources

Mechano-transduction to muscle protein synthesis is modulated by FAK [PDF]

, 2018
We examined the involvement of focal adhesion kinase (FAK) in mechano-regulated signalling to protein synthesis by combining muscle-targeted transgenesis with a physiological model for un- and reloading of hindlimbs.
Durieux, Anne-Cecile, Flueck, Martin, Freyssenet, Damien, Klossner, Stephan   +3 more
core  

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

OsDUF2488 acts synergistically with OsPrx1.1, regulates ROS metabolism and promotes dehydration tolerance in rice

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3879-3899, September 2025.
Summary Stress‐mediated regulation of energy metabolism and its relation to plant adaptation remain largely unknown. Mitochondrial redox potential is greatly influenced by stress‐induced reactive oxygen species (ROS); therefore, we mapped the dehydration‐induced alterations in the mitochondrial proteome of a resilient rice cultivar, Rasi, generating a ...
Dipak Gayen, Sunil Kumar, Pragya Barua, Nilesh Vikram Lande, Subhasis Karmakar, Amit K. Dey, Saurabh Gayali, Tushar Kanti Maiti, Kutubuddin Ali Molla, Snehal Murumkar, Subhra Chakraborty, Niranjan Chakraborty   +11 more
wiley   +1 more source

Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR‐Induced AMPK Activation and Glucose Uptake in L6 Myotubes

BioFactors, Volume 51, Issue 4, July/August 2025.
Mycophenolate mofetil, alanosine, trimetrexate, and sulfamethoxazole mimic methotrexate's effects by enhancing AICAR‐induced AMPK activation and glucose uptake in L6 myotubes. Collectively, our results suggest that IMP metabolism may serve as a gateway for the modulation of AMPK and its metabolic effects in skeletal muscle cells. ABSTRACT Methotrexate,
Klemen Dolinar, Katarina Miš, Katja Šopar, Mateja Šutar, Meta Božič, Matic Kolar, Tim Hropot, Pablo M. Garcia‐Roves, Alexander V. Chibalin, Sergej Pirkmajer   +9 more
wiley   +1 more source

NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]

, 2006
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David, Boldin, Mark P., Chang, Kuang-Jung, Taganov, Konstantin D.   +3 more
core