Results 81 to 90 of about 7,937 (203)
Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Bachmeier, B. E. +4 more
core +1 more source
Electrotransfer of CpG free plasmids enhances gene expression in skin [PDF]
Bioelectrochemistry, 2019 Skin is a very suitable target for gene therapy and DNA vaccination due to its accessibility, its surface and its ability to produce transgenes. Gene electrotransfer (GET) to the skin is under development for clinical applications for DNA vaccine or local treatment such as wound healing.
S, Chabot +5 more
openaire +2 more sources
Food Frontiers, Volume 6, Issue 6, Page 2823-2838, November 2025.Our results indicate that maternal ISO‐S during late gestation and throughout lactation can improve offspring intestinal homeostasis, which may be related to antioxidant enzymes and immunoglobulins in sow colostrum through maternal metabolome–microbiome intestine interactions.
Changming Hong +9 more
wiley +1 more source
Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space [PDF]
, 1992 Cytochrome b2 reaches the intermembrane space of mitochondria by transport into the matrix followed by export across the inner membrane. While in the matrix, the protein interacts with hsp60, which arrests its folding prior to export.
Guiard, Bernard +6 more
core +1 more source
ELECTROTRANSFER OF CYTOKINE GENES FOR CANCER TREATMENT
CBU International Conference Proceedings, 2018 Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a physical method for transfecting genes into cells and tissues. Many reports for the utilization of this techniques in animals confirmed that gene electrotransfer is a safe and efficient method.
Sonam Chopra, Saulius Satkauskas
openaire +1 more source
The FEBS Journal, Volume 292, Issue 19, Page 5046-5066, October 2025.We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika +7 more
wiley +1 more source
Sustained and promoter dependent bone morphogenetic protein expression by rat mesenchymal stem cells after BMP-2 transgene electrotransfer [PDF]
European Cells & Materials, 2012 Transplantation of mesenchymal stem cells (MSCs) with electrotransferred bone morphogenetic protein-2 (BMP-2) transgene is an attractive therapeutic modality for the treatment of large bone defects: it provides both stem cells with the ability to form ...
E Ferreira +7 more
doaj
The FEBS Journal, Volume 292, Issue 20, Page 5525-5539, October 2025.A loss of function TNNT1 myopathy mouse model with the nonsense mutation p.E180* showed potential cytotoxicity of the truncated slow troponin T fragment. The mRNA expression profile in the soleus muscle of Tnnt1‐p.E180* mice showed very different changes in comparison to that of Tnnt1‐knockout mice.
Han‐Zhong Feng +2 more
wiley +1 more source
Vaccines, 2020 Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in ...
Felipe Maglietti +6 more
doaj +1 more source
Mechano-transduction to muscle protein synthesis is modulated by FAK [PDF]
, 2018 We examined the involvement of focal adhesion kinase (FAK) in mechano-regulated signalling to protein synthesis by combining muscle-targeted transgenesis with a physiological model for un- and reloading of hindlimbs.
Durieux, Anne-Cecile +3 more
core